Association of Pre‐Pregnancy Body Mass Index and Gestational Weight Gain with Preterm Births and Fetal Size: an Observational Study from <scp>L</scp>ebanon

Rafei, Rym El; Abbas, Hussein A.; Charafeddine, Lama; Nakad, Pascale; Bizri, Ayah Al; Hamod, Dany Al; Yunis, Khalid

doi:10.1111/ppe.12249

Cited by 39 publications

(42 citation statements)

References 38 publications

(115 reference statements)

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“…Our result regarding extremely preterm birth is also consistent with results from a Swedish study [22]. A systematic review of studies from lowand middle-income countries reported that maternal underweight was significantly associated with an increased risk of preterm birth [15], and a hospital-based study from Lebanon also indicated an increased risk of preterm birth only among underweight women with low GWG [23]. The inconsistent results could be due to the different ethnicities.…”

Section: Discussion/conclusionsupporting

confidence: 86%

Prepregnancy Overweight and Obesity Are Associated with an Increased Risk of Preterm Birth in Chinese Women

Huang

et al. 2020

Obes Facts

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Introduction: The association between obesity before pregnancy and preterm birth varies with age and ethnicity. Objective: To study the association between early body mass index (BMI) and risk of preterm birth in Chinese women. Methods: This was a hospital-based retrospective cohort study including 36,596 Chinese women who gave birth to a live singleton infant from 2015 to 2018. Women were classified as underweight (BMI < 18.5), normal weight (BMI 18.5 to < 23), overweight (BMI 23 to < 27.5), or obese (BMI ≥27.5) according to the most recent criteria for Asian women. Multivariate log-binomial regression models were used to estimate the relative risks (RRs) and 95% confidence intervals (95% CIs) for preterm birth among different groups. Results: Compared to women with normal weight, women with overweight or obesity before pregnancy had an increased risk of preterm birth; the RRs and 95% CIs were 1.22 (95% CI: 1.08-1.37) and 1.30 (95% CI: 1.01-1.69), respectively. The greatest risk of extremely preterm birth was observed in obese women. The estimators were robust when considering the maternal age and rate of gestational weight gain (GWG) during pregnancy. Conclusions: Women with overweight and obesity had an increased risk of preterm birth regardless of GWG in early pregnancy. Our study suggests that it is beneficial to lose weight before conception for both overweight and obese women who plan to become pregnant.

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Section: Discussion/conclusionsupporting

confidence: 86%

Prepregnancy Overweight and Obesity Are Associated with an Increased Risk of Preterm Birth in Chinese Women

Huang

et al. 2020

Obes Facts

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“…Our findings help to explain the inconsistent findings between pre-pregnancy BMI and PTB outcomes reported in previous studies202122232425262728 and suggest that such inconsistency may be partly due to the interactions between maternal genotype (that is, rs11161721) and pre-pregnancy BMI. We showed that the impact of pre-pregnancy BMI on overall PTB risk depends on the maternal genotype at rs11161721.…”

Section: Discussionsupporting

confidence: 51%

“…First, maternal pre-pregnancy overweight/obesity (OWO) is prevalent in the BBC (>50%), which is significant from clinical and public health perspectives, and also ensures sufficient statistical power to identify a significant G × E interaction in this study. In addition, previous studies on the associations of pre-pregnancy BMI or OWO with PTB have yielded inconsistent results, including positive20212223, null2425 or negative associations262728. It is possible that such inconsistent findings may be in part due to maternal gene × pre-pregnancy BMI interaction29, which is largely unexplored.…”

mentioning

confidence: 99%

Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth

et al. 2017

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Preterm birth (PTB) contributes significantly to infant mortality and morbidity with lifelong impact. Few robust genetic factors of PTB have been identified. Such ‘missing heritability' may be partly due to gene × environment interactions (G × E), which is largely unexplored. Here we conduct genome-wide G × E analyses of PTB in 1,733 African-American women (698 mothers of PTB; 1,035 of term birth) from the Boston Birth Cohort. We show that maternal COL24A1 variants have a significant genome-wide interaction with maternal pre-pregnancy overweight/obesity on PTB risk, with rs11161721 (PG × E=1.8 × 10−8; empirical PG × E=1.2 × 10−8) as the top hit. This interaction is replicated in African-American mothers (PG × E=0.01) from an independent cohort and in meta-analysis (PG × E=3.6 × 10−9), but is not replicated in Caucasians. In adipose tissue, rs11161721 is significantly associated with altered COL24A1 expression. Our findings may provide new insight into the aetiology of PTB and improve our ability to predict and prevent PTB.

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“…Preterm Birth  Cigarette smoking (Bottorff et al, 2014)  Cigarette smoking (Koullali et al, 2016)  Exposure to environmental tobacco (Ashford et al, 2010;Crane et al, 2011;Savitz & Murnane, 2010)  Alcohol, cannabis and other illicit drug use (Salas-Wright et al, 2015)  Cannabis use (Prunet et al, 2016)  Sub-optimal nutrition (Bloomfield, 2011)  Inappropriate gestational weight gain (Haggarty et al, 2009;Harper et al, 2011)  Low/high body mass index (Koullali et al, 2016)  Inappropriate gestational weight gain (El Rafei et al, 2016)  Maternal anxiety and/or depression (Siegel & Brandon, 2014)  Maternal anxiety (Liou et al, 2016)  Maternal depression (Accortt et al, 2014)  Stress (Straub et al, 2014)  Intimate partner violence (Edirne et al, 2010;O'Donnell et al, 2009)  Intimate partner violence (Donovan et al, 2016)  'Inadequate' antenatal care (Debiec et al, 2010;Raatikainen et al, 2007)  'Inadequate' antenatal care (Prunet et al, 2016)  Genito-urinary infection (Goyal et al, 2016)  Genito-urinary infection (Sangkomkamhang et al, 2008)…”

Section: Adolescent Pregnancymentioning

confidence: 99%

How optimal caseload midwifery can modify predictors for preterm birth in young women: Integrated findings from a mixed methods study

2016

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the institutional infrastructure and managerial support for caseload midwifery should value and prioritise the philosophical commitments and personal attributes required to optimise the model. Furthermore the location of visits, between appointment access to primary midwife, and back-up system should be organised to optimise the midwife-woman relationship in order to promote the young woman's engagement with maternity care.

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Association of Pre‐Pregnancy Body Mass Index and Gestational Weight Gain with Preterm Births and Fetal Size: an Observational Study from Lebanon

Cited by 39 publications

References 38 publications

Prepregnancy Overweight and Obesity Are Associated with an Increased Risk of Preterm Birth in Chinese Women

Prepregnancy Overweight and Obesity Are Associated with an Increased Risk of Preterm Birth in Chinese Women

Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth

How optimal caseload midwifery can modify predictors for preterm birth in young women: Integrated findings from a mixed methods study

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