Association of PPARG rs3856806 C&gt;T polymorphism with body mass index, glycaemia and lipid parameters in Serbian adolescents

Vidović, Vanja; Maksimović, Nela; Vidović, Stojko; Damnjanovic, Tatjana; Novaković, Ivana

doi:10.5937/scriptamed52-29376

Cited by 3 publications

(4 citation statements)

References 34 publications

(44 reference statements)

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“…These findings closely resemble results obtained in our study, in which CC genotype ( PPARG rs3856806) was significantly associated with higher mean HDL-c values and carriers of variant alleles of both PPARG rs3856806 and PPARGC1A rs8192678 presented significantly lower serum HDL-c levels. Still, the authors also report higher fasting blood glucose levels within the same CT and TT genotype group ( 57 ), which we could not trace in our study. Contradictorily, Fan et al reported a correlation between minor allele variants of rs3856806 and elevated LDL-c levels in Chinese adults ( 61 ).…”

Section: Discussioncontrasting

confidence: 87%

“…Queiroz et al reported no association for PPARG rs1801282 and several anthropometric and metabolically-related parameters (BMI, WC, total cholesterol, LDL/HDL cholesterol, insulin, and HOMA-IR, body fat percentage, birth weight, systolic blood pressure), within a research article conducted on Brazilian children and adolescents ( 56 ). Two other reports described an insignificant impact of PPARG rs3856806 polymorphism on BMI value variations among children and adolescents ( 57 , 58 ). In our study we failed to identify an association between three polymorphisms of PPARG and children with overweight and obesity.…”

Section: Discussionmentioning

confidence: 89%

“…Relevant associations between metabolic parameters, lipid profile, and PPARG polymorphisms have though been found, even among studies that could not conclude that the analyzed gene variants represent an obesity/overweight risk. Particularly, Vidovic et al found lower mean values of HDL-c in the CT and TT genotype of PPARG rs3856806, despite of a lack of association between the aforementioned polymorphism and overweight/obesity among Serbian adolescents ( 57 ). These findings closely resemble results obtained in our study, in which CC genotype ( PPARG rs3856806) was significantly associated with higher mean HDL-c values and carriers of variant alleles of both PPARG rs3856806 and PPARGC1A rs8192678 presented significantly lower serum HDL-c levels.…”

Section: Discussionmentioning

confidence: 99%

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Effects of PPARG and PPARGC1A gene polymorphisms on obesity markers

Muntean

Săsăran

Crisan

et al. 2022

Front. Public Health

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Pediatric obesity presents a multifactorial etiology, which involves genetic traits as well, including single nucleotide polymorphisms. The aim of the study is to investigate the contribution of PPARG gene polymorphisms (namely Pro12Ala rs1801282, His447His rs3856806, and Pro115Gln rs1800571) and PPARGC1A rs8192678 SNP on the anthropometric and metabolic parameters in a population of Romanian children. We conducted a cross-sectional study of 295 Caucasian children, divided according to the body mass index (BMI) z-score into the study (obese and overweight) group of 130 children and the control (normoponderal) group of 165 children. Anthropometric parameters were greater in the obese and overweight population as opposed to controls, with significant differences (p < 0.01) found for the weight (2.77 ± 1.54 SD vs. −0.04 ± 1.15 SD), body mass index (BMI) (2.28 ± 0.97 SD vs. −0.18 ± 1.19 SD), mid-upper arm circumference (MUAC) (4.59 ± 2.28 SD vs. 0.28 ± 3.45 SD), tricipital skin-fold (TSF) (3.31 ± 3.09 SD vs. 0.62 ± 7.28 SD) and waist-to-height ratio (WHtR) (0.61 ± 1.51 SD vs. −0.35 ± 1.35 SD) z-scores. Moreover, triglyceride values were higher in the study group (118.70 ± 71.99 SD vs. 77.09 ± 37.39 SD). No significant difference in the allele and genotype distribution of investigates gene polymorphisms was observed between the studied groups (p > 0.05). PPARG (rs1801282, rs3856806, and rs1800571) were not associated with demographic, anthropometric, and laboratory parameters. However, PPARGC1A rs8192678 CC genotype was associated with TSF z-score (p = 0.03), whereas total and LDL cholesterol levels were significantly higher among TT homozygotes (p < 0.01). Our data suggest that PPARG (rs1801282, rs3856806, and rs1800571) and PPARGC1A (rs8192678) gene polymorphisms were not associated with childhood and adolescence overweight and obesity. The present study identified a significant increase in fasting glucose levels, triglyceride, albumin, and ALT levels in children with excess weight, as well as expected important upward variation of anthropometric parameters (BMI, MUAC, TSF z-scores).

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Section: Discussioncontrasting

confidence: 87%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of PPARG and PPARGC1A gene polymorphisms on obesity markers

Muntean

Săsăran

Crisan

et al. 2022

Front. Public Health

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“…Also, in the period of adolescence, boys tend to have more physical activities than girls, which might be one of the reason for difference in BMI (23). On the other side impact of increased secretion of testosterone in adolescent boys, leads to the higher lipase activity in the liver, which causes lowering of the lipid parameters as well as lower BMI (24). However, many of these studies measured the circulating level of protein in particular populations, but association of rs4644 genotype was not addressed.…”

Section: Discussionmentioning

confidence: 99%

Galectin 3 rs4644 gene polymorphism is associated with metabolic traits in Serbian adolescent population

Vidović,

Novaković,

Damnjanović

et al. 2024

J Med Biochemistry

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Background: Among many genes which have been analyzed to understand obesity and related metabolic traits among children and adolescents, not many studies are conducted on LGALS3 gene, especially in population of children. A positive correlation of circulating galectin 3 serum levels with impaired blood glucose, high blood pressure and higher values of serum lipids and was found in general population. The aim was to investigate possible association of rs4644 with body mass index, glycaemia, and lipid profile in Serbian adolescents. Methods: The study included 72 boys and 79 girls, 14-15 years of age. Among boys 51 (67.1%) had normal values of BMI, 11 (14.5%) were overweight, and 14 (18.4%) were obese. Among girls, 53 (63.9%) had normal BMI, 16 (19.3%) were overweight, and 14 (16.9%) were obese. Diabetes type 1 or 2, genetic syndromes, generalized inflammation, cardiovascular and malignant diseases were criteria for exclusion. Genotyping was performed by Real time PCR. Results: Girls carriers of CC genotype had statistically higher mean values of BMI, and triglycerides in comparison to the girls carriers of CA+AA genotypes, p=0.041, and p=0.045, respectively. The higher frequency of obese was found among group of girls who were carriers of CC genotype, p=0.049. No statistically significant association was observed among other analyzed parameters in neither examined groups. Conclusion: Our research indicates that there is an association between the CC genotype of rs4644 polymorphism with obesity and higher triglycerides level in the group of female adolescents.

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PPARGC1A gene polymorphism and its association with obesity-related metabolic traits in Serbian adolescent population

et al. 2022

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PPARGC1A is involved in many metabolic processes including normal mitochondrial biogenesis, oxidation of glucose and lipids and transport of glucose into skeletal muscles. Previous researches linked this polymorphism with the higher risk of developing type 2 diabetes, metabolic syndrome and obesity. The aim of the study was to investigate the association of Gly482Ser with body mass index (BMI), fasting glucose levels and lipid profile in Serbian adolescents. The study included 147 boys and 150 girls, 15 years of age. Anthropometric and biochemical parameters were recorded. Cardiovascular and malignant diseases, type 2 diabetes, cerebral palsy and genetics syndrome were criteria for exclusion. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (RFLP) assay. The results showed that boys carriers of GG genotype had statistically higher mean values of TC compared to the boys who were carriers of GA+AA genotypes (p=0.033). However, statistical significance was not obtained for the other analyzed parameters. Furthermore, in the group of overweight and obese children, higher mean values of TC and LDL-C were observed in the carriers of GG genotype compared to carriers of GA+AA genotype for all the adolescents, as well as in the group of girls. No correlation was observed for values of BMI, fasting blood glucose and levels of triglycerides. To confirm these results, further research with larger sample size and non-genetics factor taking into consideration, would be of great interest.

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Association of PPARG rs3856806 C>T polymorphism with body mass index, glycaemia and lipid parameters in Serbian adolescents

Cited by 3 publications

References 34 publications

Effects of PPARG and PPARGC1A gene polymorphisms on obesity markers

Effects of PPARG and PPARGC1A gene polymorphisms on obesity markers

Galectin 3 rs4644 gene polymorphism is associated with metabolic traits in Serbian adolescent population

PPARGC1A gene polymorphism and its association with obesity-related metabolic traits in Serbian adolescent population

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