Association of PPARG Pro12Ala polymorphism with insulin sensitivity and body mass index in patients with polycystic ovary syndrome

Baldani, Dinka Pavičić; Škrgatić, Lana; Černe, Jasmina-Živa; Ferk, Polonca; Šimunić, Velimir; Geršak, Ksenija

doi:10.3892/br.2013.215

Cited by 24 publications

(17 citation statements)

References 59 publications

(91 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding was previously described in insulin-resistance and obese women, reinforcing our results. 22 Interestingly, Amerindian populations (Mazahuas and Nahuas) exhibited the highest frequencies of the Ala12 allele (25%), which was in agreement with previous studies in Yaquis, Mayas, and Triquis. 23 Conversely, European (≤10%) and African (≤1%) ethnicities showed lower frequencies of Ala12 than in Mestizos and Amerindians.…”

Section: Discussionsupporting

confidence: 80%

PPARG-LYPLAL1 Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females

et al. 2016

View full text Add to dashboard Cite

Objective: We studied multi-loci variants to identify the contribution of six candidate genes (ADIPOQ, CDH13, LYPLAL1, MC4R, PPARG and PGC1A) in the development of obesity and overweight. Design:We genotyped 404 chromosomes with eleven SNPs in Mexican female adolescents, who were subdivided into two groups (obesity-overweight and normal-weight) using the World Health Organization parameters. Genomic (800 chromosomes) and ancestral (208 chromosomes) controls were included to reduce the population bias. Anthropometric measurements, biochemical parameters, and caloric intake were obtained only in the groups of Mexican female adolescents. Results:A positive genotype-phenotype association was found that involves the multi-allelic combination of three risk alleles (one in PPARG and two in LYPLAL1) with obesity and overweight (OR=3.1, P=.010). This combination also exhibited a significant association with waist circumference (P=.030) and triglycerides levels (P=.030). These associations were supported by a logistic regression analysis adjusted for several confounding variables. Conclusions:Our data suggest the joint participation of PPARG-LYPLAL1 genes in metabolic disorders development. Hence, these genes could act as potential biomarkers in obesity and overweight. Our findings underscore the complexity of metabolic disorders and provide evidence about the importance of multi-loci analysis to study complex diseases. Ethn Dis.

show abstract

Section: Discussionsupporting

confidence: 80%

PPARG-LYPLAL1 Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In our study with Indian women we observed that carriers of polymorphic Pro12Ala (CG+GG) genotype had significantly lower 2 hr glucose levels [82]. A recent study also demonstrated that Pro12Ala was significantly associated with insulin sensitivity in lean PCOS women of Croatian population [84]. On the contrary, studies in German, Chinese, Caucasian, and Greek population showed no association of this polymorphism with PCOS [81,[85][86][87][88][89][90].…”

Section: Pparcontrasting

confidence: 38%

Genetic Markers of Polycystic Ovary Syndrome: Emphasis on Insulin Resistance

Shaikh

Dadachanji

Mukherjee

2014

International Journal of Medical Genetics

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of childbearing age causing not only reproductive but also metabolic anomalies. PCOS women present with ovulatory dysfunction, abnormal hormones, hyperandrogenemia, obesity, and hyperinsulinemia. It is a heterogeneous disorder which results from interaction of multiple genes along with environmental factors. Insulin resistance is a central key element contributing to PCOS pathogenesis and is further aggravated by obesity. Insulin regulates metabolic homeostasis and contributes to ovarian steroidogenesis. Candidate gene analyses have dissected genes related to insulin secretion and action for their association with PCOS susceptibility. Although a large number of genomic variants have been shown to be associated with PCOS, no single candidate gene has emerged as a convincing biomarker thus far. This may be attributed to large amount of heterogeneity observed in this disorder. This review presents an overview of the polymorphisms in genes related to insulin signaling and their association with PCOS and its related traits.

show abstract

“…It has been argued that the epigenome could represent the mechanistic link between genetic variants and environmental factors in determining obesity risk. Major international efforts are underway to explore and document how DNA sequence polymorphisms influence an individual's predisposition to obesity and its comorbidities [23][24][25][26][27][28][29][30]. Such variations in DNA sequence offer hope of a personalized medicine where therapeutics are tailored and matched with patients presenting a particular genotype [31][32][33][34][35].…”

Section: Obesity and Epigeneticmentioning

confidence: 99%

WITHDRAWN: Could some epigenetic modifications hold the key to opposing the metabolic syndrome?

Tarantino¹,

Minno²,

Finelli³

2016

Oncotarget

View full text Add to dashboard Cite

The role of epigenetic mechanisms in the pathogenesis of diseases has been increasingly recognized over recent years. Due to the intrinsic flexibility of the chromatin structure both in response to diet and environment, and as a result of foreseeable therapeutic interventions, epigenetics has emerged as a promising conceptual frame to investigate chronic degenerative disorders. This applies particularly to diet-driven and environment-driven metabolic disorders, such as obesity and its complications, including atherosclerosis and non-alcoholic fatty liver diseases (NAFLD). Current evidence strongly suggests that chronic inflammation is a landmark of obesity, atherosclerosis, and NAFLD, and that markers of inflammation are important predictors of cardiovascular risk factors. A crucial question is how pro-inflammatory gene expression patterns are established and maintained in the aforementioned illnesses. Epigenetic gene regulation is a partially new entry in the field of cardiovascular diseases. Epigenetic modifications provide attractive candidate disease mechanisms by explaining, in principle, how diet, environment and lifestyle might impose aberrant gene expression patterns in the individual's lifetime, which can also be considered the result of trans-generational epigenetic inheritance. The main long-term goals in this field are to identify and understand the role of the epigenetic marks that could be used as early predictors of metabolic risk, and possibly develop drugs or diet-related treatments able to delay these epigenetic changes or even reverse them. Therefore, a continued and greater understanding of these mechanisms will eventually help identify individuals at high risk of the Metabolic Syndrome, and develop therapeutic interventions, in accordance with current global government strategy, utilizing also PUFA rich foods.

show abstract

Association of PPARG Pro12Ala polymorphism with insulin sensitivity and body mass index in patients with polycystic ovary syndrome

Cited by 24 publications

References 59 publications

PPARG-LYPLAL1 Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females

PPARG-LYPLAL1 Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females

Genetic Markers of Polycystic Ovary Syndrome: Emphasis on Insulin Resistance

WITHDRAWN: Could some epigenetic modifications hold the key to opposing the metabolic syndrome?

Contact Info

Product

Resources

About