Association of polymorphisms of cytokine genes (IL1B, IL1RN, TNFA, LTA, IL6, IL8, and IL10) with chronic obstructive pulmonary disease

Данилко, К. В.; Korytyna, G. F.; Akhmadishina, L. Z.; Yanbaeva, D. G.; Загидуллин, Ш. З.; Victorova, T. V.

doi:10.1134/s0026893307010049

Cited by 33 publications

(23 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many candidate genes, including IL-6 (Broekhuizen et al, 2005;Danilko et al, 2007;Córdoba-Lanús et al, 2008;He et al, 2009), IL-8 (Shen et al, 2008, tumor necrosis factor (Küçükaycan et al, 2002), disintegrin and metalloprotease 33 (Sadeghnejad et al, 2009;Wang et al, 2009;Xiao et al, 2011), and beta 2-adrenoceptor (Hegab et al, 2004;Matheson et al, 2006) have been reported to be involved in COPD susceptibility. IL-6 is a potential mediator of inflammation in COPD, and has been shown to be increased in serum, exhaled breath condensate, and sputum during stable conditions and exacerbation, predicting a faster decline in forced expiratory volume in one second (Agustı et al, 2003;Donaldson et al, 2005;He et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The most studied IL-6 polymorphism, IL-6 -174G>C, has been shown to be associated with an increased risk of cardiovascular events and related risk factors such as C-reactive protein, fibrinogen, and hypertension (Jenny et al, 2002;Vickers et al, 2002;Chaouat et al, 2009). That being said, the results for the relationship between IL-6 -174G>C variants and COPD risk are inconsistent (Broekhuizen et al, 2005;Seifart et al, 2005;Danilko et al, 2007;Córdoba-Lanús et al, 2008;Hsieh et al, 2008;He et al, 2009;Zhou et al, 2012). Therefore, it is critical to systematically evaluate all studies from different groups and to quantify the overall risk associated with the IL-6 -174G>C polymorphism and COPD.…”

Section: Discussionmentioning

confidence: 99%

“…After reviewing the titles, abstracts and articles, 18 studies were excluded. Finally, 7 studies matched the inclusion criteria, and were included in the metaanalysis (Broekhuizen et al, 2005;Seifart et al, 2005;Córdoba-Lanús et al, 2008;Danilko et al, 2007;He et al, 2009;Hsieh et al, 2008;Zhou et al, 2012). All of the studies included used peripheral blood samples for DNA extraction.…”

Section: Study Charactersmentioning

confidence: 99%

“…One such polymorphism is the IL-6-174G>C (also called rs1800795) polymorphism in the IL-6 promoter. However, other studies have not shown such an association between the IL-6 -174G>C polymorphism and COPD risk (Danilko et al, 2007;Hsieh et al, 2008;Zhou et al, 2012). One reason for this discrepancy could be that all of the above studies were performed in an individual medical center with a small sample size.…”

Section: Introductionmentioning

confidence: 96%

See 3 more Smart Citations

Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Xie¹,

Ke²,

Yh³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Association studies of interleukin-6 (IL-6) -174G>C polymorphism and chronic obstructive pulmonary disease (COPD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. A comprehensive search was performed in the PubMed, Embase, Elsevier, Web of Science databases, Wanfang, and the Chinese National Knowledge Infrastructure (CNKI) databases for published studies investigating the associations between IL-6 -174G>C polymorphism and COPD. Odds ratios (OR) and 95% confidence intervals (95%CI) were used to assess the possible associations. Seven studies with a total of 2701 subjects were included in this meta-analysis. A significantly increased risk was detected in the C allele of the IL-6 -174G>C in Caucasians (C vs G: OR = 1.16, 95%CI = 1.03-1.30; CC+GC vs GG: OR = 1.21, 95%CI = 1.02-1.42; CC vs GG: OR = 1.32, 95%CI = 1.03-1.70). This meta-analysis suggests that the C allele of the IL-6 -174G>C might act as a COPD risk factor in 8517 IL-6 polymorphism and COPD risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 8516-8525 (2015) Caucasians. Further well-designed case-control studies with larger sample sizes are needed to confirm these conclusions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Charactersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Xie¹,

Ke²,

Yh³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…However, inconsistent results have been reported (Ishii et al, 2000;Asada et al, 2005;Hegab et al, 2005;Broekhuizen et al, 2005;Shi et al, 2006;Danilko et al, 2007;Lee et al, 2008;Trajkov et al, 2009;Liu et al, 2012;Shukla et al, 2012;Sun et al, 2013;Issac et al, 2014), which may be because of differences in ethnicity and sample size between studies, resulting in lower statistical power. Meta-analysis may be useful for pooling independent statistical powers and thus achieving a quantitative understanding of the associations.…”

Section: Introductionmentioning

confidence: 98%

Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis

Wang

Liu²,

Xu³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Studies examining the role of interleukin (IL)-1β -511C/ T promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) have shown inconsistent results. This metaanalysis was performed to assess the association between the IL-1β -511C/T promoter polymorphism and COPD susceptibility. Published case-control, cross-sectional, and cohort studies from Pubmed, Embase, and China National Knowledge Infrastructure databases were retrieved. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Twelve studies with 1692 cases and 2009 controls were included in this meta-analysis. Pooled effect size showed an overall but not significantly decreased risk of IL-1β -511 C/T with COPD susceptibility (OR = 0.89, 95%CI = 0.78-1.01) in a complete overdominant genetic model (TT+CC vs CT), indicating that homozygous individuals (CC and TT) have a decreased risk for COPD compared with heterozygotes (2015) (CT). In subgroup analysis by ethnicity, IL-1β -511C/T was significantly correlated with a decreased risk of COPD in Asians (OR = 0.73, 95%CI = 0.60-0.88, P = 0.001), but not in Caucasians (OR = 1.02, 95%CI = 0.83-1.24, P = 0.46), confirming a protective role of IL-1β -511C/T in COPD in Asians. Moreover, after excluding studies that included populations not in Hardy-Weinberg equilibrium, the pooled results were robust and no publication bias was observed. This meta-analysis suggests that the IL-1β -511C/T promoter polymorphism deceases the risk of COPD in Asians.

show abstract

Interleukin 10 promoter region polymorphisms in inflammatory bowel disease in Tunisian population

et al. 2009

View full text Add to dashboard Cite

show abstract

Association of polymorphisms of cytokine genes (IL1B, IL1RN, TNFA, LTA, IL6, IL8, and IL10) with chronic obstructive pulmonary disease

Cited by 33 publications

References 20 publications

Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis

Interleukin 10 promoter region polymorphisms in inflammatory bowel disease in Tunisian population

Contact Info

Product

Resources

About