Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk

Kutikhin, Anton G.

doi:10.1016/j.humimm.2011.07.307

Cited by 105 publications

(95 citation statements)

References 264 publications

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“…TLRs have been reported as expressed in different cancer cell lines and TLR polymorphisms have been associated with different types of neoplasms (12,19,20). In healthy tissues, activation of TLRs may cause chronic inflammation, which has been demonstrated to represent a favorable environment for tumor initiation and progression (21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

“…The human TLR family consists of ≥10 members: TLR1, 2, 4, 5, 6 and 10 are usually expressed on the cell surface, whereas TLR3, 7, 8 and 9 are mainly expressed on the surfaces of endosomes, lysosomes and the endoplasmic reticulum (8). TLRs are implicated in the innate and adaptive immune response (9)(10)(11), and also in cellular proliferation, differentiation, mitosis, cell-cycle regulation, apoptosis, angiogenesis and tissue remodelling (12,13 pathways that are responsible for the induction of nuclear transcription factors (14). Genes induced by the activation of TLRs encode for several inflammatory cytokines, notably tumor necrosis factor-α (TNF-α), including interferon (IFN) 1, interleukin-6 (IL-6), IL-1, granulocyte-colony stimulating factor, and different chemokines, including CCL2 and CXCL10 (7,14).…”

Section: Introductionmentioning

confidence: 99%

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Association between Toll-like receptor 7 Gln11Leu single-nucleotide polymorphism and basal cell carcinoma

et al. 2016

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Abstract. Non-melanoma skin cancers (NMSC) are the most common form of human skin cancer. The majority of NMSC are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) with a BCC:SCC incidence ratio of 4:1 in immunocompetent patients. Toll-like receptors (TLRs) are transmembrane glycoproteins that recognize pathogen-associated molecular patterns and damage-associated molecular patterns, against which they activate the innate immune response and initiate the adaptive immune response. Genetic variations of these receptors can alter the immune system and are involved in evolution and susceptibility of various diseases, including cancer. Imiquimod, an agonist of TLR7, is applied topically in the treatment of premalignant and malignant skin disorders, in particular BCC. The high efficacy of this TLR7 agonist toward BCC supports a possible role of this receptor in the induction of BCC and, consequently, polymorphisms of this receptor could be responsible for a greater or lesser susceptibility to BCC. The aim of the present study was to evaluate whether the presence of the functional TLR7 rs179008/Gln11Leu promoter polymorphism conferred an increased susceptibility to BCC. A case-control study with 177 BCC cases and 158 controls was performed to highlight the possible association between this polymorphism and the susceptibility to BCC. As the TLR7 gene is localized on chromosome X, the allelic frequency of this polymorphism was analyzed separately in males and females. The analysis of the distribution of frequencies of wild-type TLR7 and variant TLR7 carrying the single-nucleotide polymorphism (SNP) rs179008 in patients with BCC and healthy subjects did not reveal any statistically significant difference between cases and controls. This study does not suggest the involvement of the SNP rs179008 of TLR7 in the susceptibility to BCC, but cannot exclude a role for TLR7 in BCC carcinogenesis considering the high efficacy of the TLR7 agonist, imiquimod, in the treatment of this neoplastic disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between Toll-like receptor 7 Gln11Leu single-nucleotide polymorphism and basal cell carcinoma

et al. 2016

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“…TLRs play a key role in the realization of innate and adaptive immune response though directly recognizing antigen determinants of viruses, bacteria, protozoa, and fungi (Kutikhin, 2011). Recently, many studies have investigated the association between TLRs polymorphisms and cancer risk (Zhou et al, 2006;He et al, 2007;Purdue et al, 2009;Ng et al, 2010;Monroy et al, 2011), but the results were inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Lack of Association of Three Common Polymorphisms in Toll-like receptors (TLRs), TLR2+597T>C, +1350C>T and Arg753Gln with Cancer Risk: a Meta-analysis

Yang

Wang²,

Qiu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Sonuç olarak, proinflamatuar gen transkripsiyonu, protein translasyonu ve / veya transkript stabilitesi artar [14]. Yapılan bir çalışmada, MyD88'in diyabetin önlenmesinde çok önemli yere sahip olduğu, MyD88'den yoksun farelerde şiddetli diyabetin geliştiği belirtilmiş ve diyabette MyD88'in önemi vurgulanmıştır [15]. Son zamanlarda yapılan bir çalışmada iki polimorfizmin 986 C/A (rs1319438) ve 1115 C/T (rs199396) MyD88'in fonksiyonunu kaybetmesine dolayısıyla NF-κB aktivasyonu ve IL-8 ve TNF-α üretiminin bozulmasına neden olduğu bildirilmiştir [16].…”

Section: Tlr-4 Sinyal Yolağı üYeleri Myd88unclassified

Genetic Variants of TLR4 and TLR4 Signal Pathway and its Association with Insulin Resistance and Diabetes Risk

Özbayer¹

2014

Ann Clin Anal Med

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ÖzetTip 2 diyabet, uzun süreli insülin direnci ve β hücre yetmezliği ile karakterize bir hastalık olup kalp, damarlar, karaciğer, böbrek ve göz gibi birçok organı etkileyerek önemli oranlarda mortalite ve morbiditeyle sonuçlanır. İnsülin direnci tip 2 diyabetin birincil karakteristik özelliğidir. Pankreasta üretilen normal miktarda insülin, yağ, kas ve karaciğer hücrelerinde gerekli veya yeterli tepkiyi oluşturamadığında insülin direnci gelişir. Toll-like reseptörler (TLR), birçok patojene karşı doğal immün cevabın oluşmasını sağlayan transmembran protein ailesidir. İnflamasyon, Toll-like reseptör (TLR) ailesinin, özellik-le TLR4'ün aktivasyonu yolu ile insülin hassasiyetini bozar. TLR4'ün LPS ile aktive olması NF-κB aktivasyonuna ve dolayısıyla TNF-α , IL-1, IL-6, iNOS ve MCP-1 gibi inflamatuar düzenleyici genlerin ekspresyonuna neden olur.

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Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk

Cited by 105 publications

References 264 publications

Association between Toll-like receptor 7 Gln11Leu single-nucleotide polymorphism and basal cell carcinoma

Association between Toll-like receptor 7 Gln11Leu single-nucleotide polymorphism and basal cell carcinoma

Lack of Association of Three Common Polymorphisms in Toll-like receptors (TLRs), TLR2+597T>C, +1350C>T and Arg753Gln with Cancer Risk: a Meta-analysis

Genetic Variants of TLR4 and TLR4 Signal Pathway and its Association with Insulin Resistance and Diabetes Risk

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