Association of polymorphisms in the <i>dopamine D4 receptor</i> gene and the activity‐impulsivity endophenotype in dogs

Hejjas, Krisztina; Vas, Judit; Topál, József; Szantai, Eszter; Rónai, Zsolt; Székely, Anna; Kubinyi, Enikő; Horváth, Zsuzsanna; Sasvári-Székely, Mária; Miklósi, Ádám

doi:10.1111/j.1365-2052.2007.01657.x

Cited by 98 publications

(92 citation statements)

References 19 publications

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“…In dogs, reduced monoaminergic levels in cerebro-spinal fluid (CSF) may be associated with aggressive behaviour and impaired impulse control in aggressive contexts [1], and serotonin and dopamine related genes have been associated with aggression and impulsivity [4], [45], [46]. These findings support the idea that trait impulsivity in dogs has a similar biological basis to other species.…”

Section: Accepted M Manuscriptsupporting

confidence: 76%

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Wright

Mills

Pollux

2012

Physiology & Behavior

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Impulsivity is a trait related to inhibitory control which is expressed in a range of behaviours. Impulsive individuals show a decreased ability to tolerate delay of reinforcement, and more impulsive behaviour has been linked to decreased levels of serotonin and dopamine in a number of species. In domestic dogs, impulsivity is implicated in problem behaviours that result from a lack of self control, but currently there are no published studies that assess behavioural and physiological measures of impulsivity in relation to this trait. Impulsivity scores were calculated for 41 dogs using an owner-report assessment, the Dog Impulsivity Assessment Scale (DIAS).Twenty-three of these subjects completed an operant choice task based on a delayed reward paradigm, to assess their tolerance to delay of reinforcement. High Pressure Liquid Chromatography (HPLC) with Fluorometric Detection was used to detect levels of the metabolites of serotonin (5-HIAA) and dopamine (HVA) in the urine of 17 of the subjects. Higher impulsivity scores were found to be significantly correlated with more impulsive behaviour (reduced tolerance to delay of reinforcement) in the behaviour tests and lower levels of urinary 5-HIAA and 5-HIAA/HVA ratio. The results demonstrate convergent validity between impulsivity (as assessed by the DIAS) and behavioural and physiological parameters.

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Section: Accepted M Manuscriptsupporting

confidence: 76%

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Wright

Mills

Pollux

2012

Physiology & Behavior

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“…Although many hereditary diseases and phenotypes have been characterized at the molecular level [15], the relationship between behavioral traits and genetics in this species has not been examined, to the best of our knowledge. Recently, we and other groups started examining behavioral genetics in dogs [18] and have reported some relationships between behavioral traits and genetic polymorphisms [8,10,17,19]. Based on the present results, we hope behavioral genetic studies in cats will begin in the near future.…”

Section: Discussionmentioning

confidence: 88%

Behavioral Profiles of Feline Breeds in Japan

Takeuchi

Mori

2009

The Journal of Veterinary Medical Science

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ABSTRACT. To clarify the behavioral profiles of 9 feline purebreds, 2 Persian subbreeds and the Japanese domestic cat, a questionnaire survey was distributed to 67 small-animal veterinarians. We found significant differences among breeds in all behavioral traits examined except for "inappropriate elimination". In addition, sexual differences were observed in certain behaviors, including "aggression toward cats", "general activity", "novelty-seeking", and "excitability". These behaviors were more common in males than females, whereas "nervousness" and "inappropriate elimination" were rated higher in females. When all breeds were categorized into four groups on the basis of a cluster analysis using the scores of two behavioral trait factors called "aggressiveness/sensitivity" and "vivaciousness", the group including Abyssinian, Russian Blue, Somali, Siamese, and Chinchilla breeds showed high aggressiveness/sensitivity and low vivaciousness. In contrast, the group including the American Shorthair and Japanese domestic cat displayed low aggressiveness/sensitivity and high vivaciousness, and the Himalayan and Persian group showed mild aggressiveness/sensitivity and very low vivaciousness. Finally, the group containing Maine Coon, Ragdoll, and Scottish Fold breeds displayed very low aggressiveness/sensitivity and low vivaciousness. The present results demonstrate that some feline behavioral traits vary by breed and/or sex.KEY WORDS: behavioral trait, breed differences, feline, questionnaire survey, sex differences.

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“…Furthermore, Hejjas et al (2007Hejjas et al ( , 2009) indicated a correlation between variability of the abovementioned gene and personality traits in dogs. Also HTR2B gene polymorphism was analyzed for the purpose of establishing whether it is linked to behavioural traits.…”

Section: Discussionmentioning

confidence: 99%

Genetic background of aggressive behaviour in dogs

Proskura

Frost

Gugała³

et al. 2013

Acta Vet. Brno

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The background of aggression is very complicated and the basis of its occurrence has not been well explained yet. It is thought that tendency to aggressiveness is an effect of both environmental and genetic factors. Aggression is a very undesirable behavioural trait in dogs living with humans. The aim of this study was to determine the relationship between two polymorphisms: DRD4 intron II VNTR and C/T substitution in exon I HTR2B genes and aggressive behaviour in dogs. The VNTR polymorphism in the DRD4 gene was detected by agarose gel electrophoresis following PCR amplification, whereas C/T substitution in the HTR2B gene was analysed using amplification created restriction sitepolymerase chain reaction (ACRS-PCR). A total of 121 dogs of several breeds were analyzed. All animals were classified based on a veterinary interview and observation in two groups: aggressive (n = 21) and non-aggressive (n = 100). Significant differences in DRD4 genotype frequencies between aggressive and non-aggressive dogs were observed (P < 0.05). The study provides a clear evidence of an association of VNTR polymorphism within intron II of the DRD4 gene with the occurrence of aggressive behaviour in dogs. Moreover, the findings give good justification for further research aimed at evaluation of the possibility of using this genetic marker in Marker-assisted Selection.

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Association of polymorphisms in the dopamine D4 receptor gene and the activity‐impulsivity endophenotype in dogs

Cited by 98 publications

References 19 publications

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Behavioral Profiles of Feline Breeds in Japan

Genetic background of aggressive behaviour in dogs

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