2014
DOI: 10.1507/endocrj.ej14-0052
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Association of polymorphisms in <i>GCKR</i> and <i>TRIB1</i> with nonalcoholic fatty liver disease and metabolic syndrome traits

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Cited by 69 publications
(81 citation statements)
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“…Our study selected 182 NAFLD patients and 195 healthy controls to observe the correlation between NCAN rs2228603 and NAFLD. We found no carriers with TT genotype both in NAFLD and control group, also no significant association of NCAN rs2228603 with NAFLD was observed in our subjects, which latter was consistent with some previous findings [32, 34, 35]. While Speliotes et al identified that variant in the gene NCAN was strongly associated with histologic NAFLD and increasing computed tomography (CT) hepatic steatosis [14].…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Our study selected 182 NAFLD patients and 195 healthy controls to observe the correlation between NCAN rs2228603 and NAFLD. We found no carriers with TT genotype both in NAFLD and control group, also no significant association of NCAN rs2228603 with NAFLD was observed in our subjects, which latter was consistent with some previous findings [32, 34, 35]. While Speliotes et al identified that variant in the gene NCAN was strongly associated with histologic NAFLD and increasing computed tomography (CT) hepatic steatosis [14].…”
Section: Discussionsupporting
confidence: 92%
“…Recently the gene NCAN on NAFLD has been studied, however, the results were controversial [23, 34]. The present study firstly evaluated the association between rs2228603 polymorphism in the gene NCAN and NAFLD in Chinese population.…”
Section: Discussionmentioning
confidence: 97%
“…Based on the crystal structures of PKA and TRIB1, we speculate that this mutation contributes to abnormal TRIB1 pseudokinase function by disrupting regulatory protein interactions with interacting partners, such as MAPKK family members [46], Ubiquitin E3 ligases, or cis -acting flanking regulatory segments in TRIB itself. Of related interest, TRIB1 gene polymorphisms are also associated with nonalcoholic liver and metabolic syndromes [63], consistent with a relatively specialized function for TRIB1 in lipid metabolism 8, 43.…”
Section: Tribbles Links To Cancer: a Corruption Of Cell Signaling?mentioning
confidence: 88%
“…Similar to TRB2, TRB1 is involved in AML progression, and drives C/EBPα degradation in leukaemia cells [95,96]. TRB1 also regulates the development of (non-alcoholic) fatty liver disease [98]. Interestingly, overexpression of the R107L cancer-associated mutant increases the degradation of C/EBPα to a greater extent than that of WT TRB1, although the mechanism remains obscure.…”
Section: Tribbles Pseudokinasesmentioning
confidence: 99%