Association of polymorphisms in inos and nqo1 with bladder cancer risk in cigarette smokers

Huang, Zhon-Min; Tung, Min‐Che; Chiang, Yi-Te; Shen, Cheng‐Huang; Juang, Guang-Dar

doi:10.1016/j.urols.2015.06.117

Cited by 3 publications

(3 citation statements)

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“…After extensive searching, a total of 7 studies have contained 1341 cases with 1346 controls on NQO1 Pro187Ser and 1921 smoking cases with 1882 controls on SULT 1A1 Arg213His. Smoking is retrieved based on the search criteria for BC susceptibility [12,[22][23][24][25][26][27][28][29][30][31][32][33]. Study characteristics were summarized in the Table 1.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Combined effects of NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism and smoking on bladder cancer risk: Two meta-analyses

Wang

Tao

et al. 2017

Int J Occup Med Environ Health

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Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Combined effects of NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism and smoking on bladder cancer risk: Two meta-analyses

Wang

Tao

et al. 2017

Int J Occup Med Environ Health

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“…Furthermore, Asher suggested protective roles for NQO1 unrelated to its enzymatic activity and involvement in apoptosis [Asher et al 2001], as it was found to act as a stabilizer for the tumor suppressor protein p53 [Liu et al 2015]. It is ubiquitously expressed in several malignancies including breast, lung, bladder, and colorectal cancers, suggesting a potential role in cellular defense during carcinogenesis [Lin et al 2014;Nagata et al 2013;Huang et al 2014;Zheng et al 2014]. Emerging studies have been performed to examine the hypothesis that the NQO1 C609T polymorphism might be associated with the risk of EC, but the results are controversial.…”

Section: Discussionmentioning

confidence: 99%

Correlation between NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and increased risk of esophageal cancer: evidence from a meta-analysis

et al. 2016

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NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphisms have been reported to influence the risk for esophageal cancer (EC) in many studies. However, the results remain controversial and ambiguous. We performed a meta-analysis, which included 13 independent studies with a total of 2357 subjects, to examine the association between NQO1 C609T polymorphism and EC. The association was assessed by five different gene models. The overall analysis suggested that the variant allele and genotypes were significantly related to increased risk of EC (odds ratio [

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“…The NAD(P)H quinine oxidoreductase 1 (NQO1; also known as diphtheria toxin diaphorase), a key phase II enzyme, plays an important role in the metabolism of several carcinogens; it also protects cells against oxidative stress [8,9]. NQO1 ac-tivity prevents the one electron reduction of quinones and thus prevents generation of free radicals by redox cycle.…”

Section: Introductionmentioning

confidence: 99%

Association of NAD(P)H Quinine Oxidoreductase 1 rs1800566 Polymorphism with Bladder and Prostate Cancers – a Systematic Review and Meta-Analysis

Abedinzadeh¹,

Moghimi²,

Dastgheib³

et al. 2020

Klin Onkol

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Background: Number of studies has been performed to investigate the association of NAD(P)H quinine oxidoreductase 1 (NQO1) rs1800566 polymorphism with risk of bladder and prostate cancers, but presented inconsistent results. Therefore, we performed a meta-analysis to provide a comprehensive data on the association of NQO1 rs1800566 polymorphism with bladder and prostate cancers. Methods: All eligible studies were identified in PubMed, Google Scholar, EMBASE, and China National Knowledge Infrastructure databases before June 01, 2019. Results: A total of 22 case-control studies includ ing 15 studies with 4,413 cases and 4,275 controls on bladder cancer and 7 studies with 762 cases and 1,813 controls on prostate cancer were selected. Over all, pooled data showed that the NQO1 rs1800566 polymorphism was significantly associated with an increased risk of bladder cancer (T vs. C: OR 1.300; 95% CI 1.112-1.518; P = 0.001; TT vs. CC: OR 1.415; 95% CI 1.084-1.847; P = 0.011; TC vs. CC: OR 1.389; 95% CI 1.111-1.738; P = 0.004; TT + TC vs. CC: OR 1.428; 95% CI 1.145-1.782; P = 0.002) and prostate cancer (TC vs. CC: OR 1.276; 95% CI 1.047-1.555; P = 0.016; TT + TC vs. CC: OR 1.268; 95% CI 1.050-1.532; P = 0.014). The stratified analysis by ethnicity revealed an increased risk of bladder cancer among Caucasians and prostate cancer among Asians. Conclusion: This meta-analysis suggested that the NQO1 rs1800566 polymorphism was significantly associated with increased risk of bladder and prostate cancers. Key wordsurinary bladder neoplasms -prostatic neoplasms -NQO1 gene -polymorphismmeta-analysisThe authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do bi omedicínských časopisů.

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Association of polymorphisms in inos and nqo1 with bladder cancer risk in cigarette smokers

Cited by 3 publications

References 0 publications

Combined effects of NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism and smoking on bladder cancer risk: Two meta-analyses

Combined effects of NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism and smoking on bladder cancer risk: Two meta-analyses

Correlation between NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and increased risk of esophageal cancer: evidence from a meta-analysis

Association of NAD(P)H Quinine Oxidoreductase 1 rs1800566 Polymorphism with Bladder and Prostate Cancers – a Systematic Review and Meta-Analysis

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