Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population

Jin, Tianbo; Li, Xiaolan; Yang, Hua; Mayer, Jiří; Shi, Xugang; Yuan, Dongya; Kang, Longli; Li, Shanqu

doi:10.1007/s12032-013-0718-1

Cited by 16 publications

(17 citation statements)

References 16 publications

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“…Also, a genome-wide linkage study demonstrated an association between several NEIL3 SNPs and type 2 diabetes [35]. Interestingly, the NEIL3 SNP found to be associated with MI in our study, rs12645561, has previously been shown to be associated with the risk of developing glioma [36] and glioblastoma [37]. The molecular interpretation of this SNP is at present not clear, given its genomic location in the splice site between exons 4 and 5.…”

Section: Geno Typecontrasting

confidence: 49%

Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case–control study. The HUNT Study

et al. 2015

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Section: Geno Typecontrasting

confidence: 49%

Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case–control study. The HUNT Study

et al. 2015

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“…It has been proposed that NEIL3 may be a potential tumor suppressor gene of hepatocellular carcinoma [15]. In addition, previous studies reported that NEIL3 SNP rs12645561 was associated with the risk of developing glioma and glioblastoma [16,17]. These observations may suggest that NEIL3 is required for the maintenance of cancer cell growth or the progression of malignancy, and that it may play a role in DNA repair as a tumor suppressor gene.…”

Section: Discussionmentioning

confidence: 99%

Genetic variants and risk of prostate cancer using pathway analysis of a genome-wide association study

Kim¹,

Kim²,

Jw³

et al. 2016

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This study explored candidate causal single nucleotide polymorphisms (SNPs) to clarify the biological mechanism of prostate cancer (PCa). Identify candidate Causal SNPs and Pathways (ICSNPathway) analysis was applied using a PCa genome-wide association study (GWAS) dataset that included 473,736 SNPs in 1151 cases of PCa and 1156 controls of European ancestry. Five candidate causal SNPs, three candidate causal genes, and two candidate causal pathways were identified using integrating linkage disequilibrium analysis, functional SNP annotation, and pathway-based analysis. The ICSNPathway analysis suggested three hypothetical mechanisms of PCa. The first was rs13112390, rs13112358, rs2048074 to nei-like DNA glycosylase 3 (NEIL3) gene to damaged DNA binding. The second was rs3087386 to REV1, DNA directed polymerase (REV1) gene to damaged DNA binding. The third was rs1063134 to potassium channel, inwardly rectifying subfamily J, member 4 (KCNJ4) gene to inward rectifier potassium channel activity.

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“…Two tag SNPs (rs4246215 and rs174538), which captured the majority of the known common variation in FEN1 according to the data on the Chinese population from HapMap (http://www.hapmap.org), were selected in our study. Sequenom MassARRAY Assay Design 3.0 Software (Agena Bioscience, San Diego, CA, USA) was used to design a multiplexed SNP MassEXTEND assay [25]. SNP genotyping was performed using the Sequenom MassARRAY RS1000 according to the standard protocol recommended by the manufacturer.…”

Section: Methodsmentioning

confidence: 99%

“…The corresponding primers used for each SNP in our study are listed in Table 8. Sequenom Typer 3.0 Software was used for data analyses [25, 26]. …”

Section: Methodsmentioning

confidence: 99%

FEN1gene variants confer reduced risk of breast cancer in chinese women: A case-control study

et al. 2016

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This study aimed to assess the associations of two common Flap endonuclease 1 (FEN1) polymorphisms (rs4246215 and rs174538) with breast cancer risk in northwest Chinese women. We conducted a case-control study with 560 breast cancer patients and 583 age-matched healthy controls from Northwest China. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to estimate the associations. We found a significantly reduced risk of breast cancer associated with T allele of rs4246215 (allele model: OR 0.81, 95% CI 0.68–0.96; homozygote model: OR = 0.59, 95% CI = 0.40–0.87; recessive model: OR = 0.61, 95% CI = 0.42–0.89), especially in postmenopausal women (OR = 0.58, 95% CI = 0.35–0.97). Furthermore, the polymorphism showed a decreased association with larger tumor size (heterozygote model: OR = 0.63, 95% CI = 0.44–0.92; dominant model: OR = 0.63, 95% CI = 0.44–0.90). For rs174538, we did not find any difference in all genetic models. However, rs174538 was associated with lymph node metastasis (heterozygote model: OR = 0.57, 95% CI = 0.39–0.81; dominant model: OR = 0.61, 95% CI = 0.43–0.86) and estrogen receptor status (heterozygote model: OR = 1.50, 95% CI = 1.05–2.15; dominant model: OR = 1.42, 95% CI = 1.01–1.98). Haplotype analysis showed that Trs4246215Grs174538 haplotype was a protective factor of breast cancer (OR = 0.34, 95% CI = 0.14–0.81). Our results suggest that FEN1 polymorphisms may reduce the risk of breast cancer in Chinese women.

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Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population

Cited by 16 publications

References 16 publications

Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case–control study. The HUNT Study

Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case–control study. The HUNT Study

Genetic variants and risk of prostate cancer using pathway analysis of a genome-wide association study

FEN1gene variants confer reduced risk of breast cancer in chinese women: A case-control study

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