Association of Polymorphism of Estrogen Receptor-.ALPHA. Gene with Circulating Levels of Adiponectin in Postmenopausal Women with Type 2 Diabetes

Yoshihara, Rie; Utsunomiya, Kazunori; Gojo, Atsushi; Ishizawa, Shin; Kanazawa, Yasushi; Matoba, Keiichiro; Taniguchi, Kanta; Yokota, Tamotsu; Kurata, Hiroyuki; Yokoyama, Jun′ichi; Urashima, Mitsuyoshi; Tajima, Naoko

doi:10.5551/jat.e471

Cited by 19 publications

(16 citation statements)

References 41 publications

(36 reference statements)

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“…Human inactivating mutations in the estrogen receptor (ER) α isotype recapitulate aspects of the metabolic syndrome (11)(12)(13)(14), and diminished ERα expression is associated with obesity in women (15). Indeed, rodents harboring a homozygous Esr1 null mutation display glucose intolerance, heightened tissue inflammation, insulin resistance, and marked obesity (16)(17)(18).…”

mentioning

confidence: 99%

Myeloid-specific estrogen receptor α deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

Ribas

Drew

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

153

137

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ERα is expressed in macrophages and other immune cells known to exert dramatic effects on glucose homeostasis. We investigated the impact of ERα expression on macrophage function to determine whether hematopoietic or myeloid-specific ERα deletion manifests obesity-induced insulin resistance in mice. Indeed, altered plasma adipokine and cytokine levels, glucose intolerance, insulin resistance, and increased adipose tissue mass were observed in animals harboring a hematopoietic or myeloid-specific deletion of ERα. A similar obese phenotype and increased atherosclerotic lesion area was displayed in LDL receptor-KO mice transplanted with ERα −/− bone marrow. In isolated macrophages, ERα was necessary for repression of inflammation, maintenance of oxidative metabolism, IL-4–mediated induction of alternative activation, full phagocytic capacity in response to LPS, and oxidized LDL-induced expression of ApoE and Abca1. Furthermore, we identified ERα as a direct regulator of macrophage transglutaminase 2 expression, a multifunctional atheroprotective enzyme. Our findings suggest that diminished ERα expression in hematopoietic/myeloid cells promotes aspects of the metabolic syndrome and accelerates atherosclerosis in female mice.

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mentioning

confidence: 99%

Myeloid-specific estrogen receptor α deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

Ribas

Drew

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

153

137

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“…The T allele of PvuII was associated with low serum levels of adiponectin, which might lead to a high risk of CVD in postmenopausal women. 41 Moreover, Hayashi et al 42 reported that only women with a TT genotype had increased arterial stiffness, whereas men did not. Ferrero et al 43 reported that women homozygous for the T allele treated with coronary stent implantation had a higher risk of in-stent restenosis than did men.…”

Section: Discussionmentioning

confidence: 99%

Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women

et al. 2009

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Estrogen was considered to be an important protective factor for cardiovascular diseases in women. Genetic association studies suggested that variations of ESR1 and ESR2 genes might have a potential role in lipid profile. Our study aimed to investigate the association of single-nucleotide polymorphisms (SNPs) of ESR1 and ESR2 with hyperlipidemia in Chinese Han postmenopausal women. A total of 443 postmenopausal women aged between 55 and 71 years were recruited from Shanghai, China for a casecontrol study (154 women with hyperlipidemia and 289 controls). We measured plasma estradiol concentration, glucose and lipid profile levels, evaluated their lifestyle and sequenced four SNPs, namely PvuII (rs2234693) and XbaI (rs9340799) of ESR1 and 1082A4G (rs1256049) and 1730A4G (rs4986938) of ESR2. PvuII (rs2234693) and XbaI (rs9340799) showed significantly different distributions between cases and controls (P¼0.002 and P¼0.023, respectively). In addition, haplotypes constructed from PvuII-XbaI were also associated with hyperlipidemia (global P¼0.012). Haplotypes T-A (P¼0.005, odds ratio (OR) 1.52, 95% confidence interval (95% CI): 1.13-2.05) and C-G (P¼0.010, OR 0.62, 95% CI: 0.43-0.89) had susceptible and protective effects, respectively. 1082A4G (rs1256049) and 1730A4G (rs4986938) showed no statistical association with hyperlipidemia. In conclusion, our results suggested that ESR1 might have a potential role in hyperlipidemia risk, independent of age, estradiol level, body mass index and lifestyle in Chinese Han postmenopausal women.

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“…Thirdly, genetic factors were not included in this study. Genetic variation in the action of estrogen plays a role in regulating circulating levels of adiponectin 46) , which may influence the change of CRF because of menopause. Further studies are needed to identify women at high risk after menopause due to genetic factors.…”

Section: Discussionmentioning

confidence: 99%

Independent Association between Age at Natural Menopause and Hypercholesterolemia, Hypertension, and Diabetes Mellitus: Japan Nurses^|^rsquo; Health Study

Lee

Hayashi

Mishra

et al. 2013

JAT

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Aim:Menopause is considered a cardiovascular risk factor (CRF), but age at menopause (AAM) varies considerably and could affect the risk among post-menopausal women. The aim of the study was to clarify whether AAM is associated with hypertension, diabetes mellitus (DM) and hypercholesterolemia, independent of chronological age, lifestyle and hormone replacement therapy (HRT), in a sizeable number of Japanese women.

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Association of Polymorphism of Estrogen Receptor-.ALPHA. Gene with Circulating Levels of Adiponectin in Postmenopausal Women with Type 2 Diabetes

Cited by 19 publications

References 41 publications

Myeloid-specific estrogen receptor α deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

Myeloid-specific estrogen receptor α deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women

Independent Association between Age at Natural Menopause and Hypercholesterolemia, Hypertension, and Diabetes Mellitus: Japan Nurses^|^rsquo; Health Study

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