Association of polymorphism in ICAM-1 (K469E) and cytology parameters in patients’ initial blood test with acute ischemic stroke

Wang, D; Fh, Zhang; Zhao, Yanyan; Xg, Xiao; S, Liu; Shi, Haibo; Al, Lin; Yj, Wang; Han, Qin; Qm, Sun

doi:10.4238/2015.december.1.2

Cited by 9 publications

(10 citation statements)

References 29 publications

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“…Among 10 studies of 58,867 participants, 2 studies [ 33 , 39 ] reported OR of high versus low NLR, 6 studies [ 35 , 37 , 38 , 40 – 42 ] reported mean differences between stroke patients and controls, and 2 studies [ 34 , 36 ] reported both. Types of stroke were ischemic stroke and TIA.…”

Section: Resultsmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Angkananard

Anothaisintawee

McEvoy

et al. 2018

BioMed Research International

222

181

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Objective This systematic review aimed to measure the association between neutrophil lymphocyte ratio (NLR) and cardiovascular disease (CVD) risk. Methods Relevant studies were identified from Medline and Scopus databases. Observational studies with NLR as a study factor were eligible for review. The outcomes of interest were any type of CVD including acute coronary syndrome, coronary artery disease, stroke, or a composite of these cardiovascular events. Mean differences in NLR between CVD and non-CVD patients were pooled using unstandardized mean difference (USMD). Odds ratios of CVD between high and low NLR groups were pooled using a random effects model. Results Thirty-eight studies (n=76,002) were included. High NLR was significantly associated with the risks of CAD, ACS, stroke, and composite cardiovascular events with pooled ORs of 1.62 (95% CI: 1.38-1.91), 1.64 (95% CI: 1.30, 2.05), 2.36 (95% CI: 1.44, 2.89), and 3.86 (95% CI: 1.73, 8.64), respectively. In addition, mean NLRs in CAD, ACS, and stroke patients were significantly higher than in control groups. Conclusion High NLR was associated with CAD, ACS, stroke, and composite cardiovascular events. Therefore, NLR may be a useful CVD biomarker.

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Section: Resultsmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Angkananard

Anothaisintawee

McEvoy

et al. 2018

BioMed Research International

222

181

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“…Three studies showed that patients with AS had higher PC than controls [24,35,36]. Eleven studies demonstrated lower PC in the patient group [12][13][14]23,[25][26][27]30,32,35,43], and 11 studies found no difference in PC between patients and controls (Table I, Supplementary Table VI) [11,15,28,29,33,37,41,42,44,46,47]. One study did not provide PC results.…”

Section: Pcmentioning

confidence: 99%

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Sadeghi

Sándor

Zsóri³

et al. 2019

Platelets

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Changes of mean platelet volume (MPV) and platelet count (PC) could be a marker or a predictor of acute stroke (AS). We conducted a systematic review and meta-analysis of the published literature on the reporting of MPV and PC in AS. Studies were included in accordance with Patient Population or Problem, Intervention, Comparison, Outcomes, and Setting framework. The PRISMA strategy was used to report findings. Risk of bias was assessed with the Newcastle-Ottawa Scale. We included 34 eligible articles retrieved from the literature. PC was significantly lower in AS patients [standardized mean difference (SMD) = − 0.30, (95% CI: − 0.49 to − 0.11), N = 2492, P = .002] compared with controls (N = 3615). The MPV was significantly higher [SMD = 0.52 (95% CI: 0.28-0.76), N = 2739, P < .001] compared with controls (N = 3810). Subgroup analyses showed significantly lower PC in both ischemic stroke (Difference SMD = −0.18, 95% CI: −0.35-0.01) and hemorrhagic stroke (−0.94, −1.62 to −0.25), but only samples by citrate anticoagulant showed significantly lower result for patients compared to controls (−0.36, −0.68 to −0.04). Ischemic stroke patients had higher MPV (0.57, 0.31-0.83), and samples by Ethylenediaminetetraacetic acid (EDTA) anticoagulant showed significantly higher result for patients compared to controls (0.86, 0.55--1.17). PC and MPV appeared to be significantly different between patients with AS and control populations. MPV was significantly higher in ischemic stroke and PC was significantly lower in both ischemic and hemorrhagic strokes. These characteristics might be related to AS and associated with it. It is advisable to pay attention to elapsed time between phlebotomy and hematology analysis, anticoagulant and hemocytometer types in AS. Systematic review registration: This meta-analysis is registered on the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42017067864 (https:// www.crd.york.ac.uk/prospero/display_record.php?RecordID=67864).

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“…Our research included 20 studies from four continents and four different countries and included 3,137 cases and 15,382 controls. Fifteen studies were from China (Geng, 2011;Guo, Liu, & Guo, 2011;Huihua et al, 2016;Li et al, 2009;Liu, 2005;Shang, 2004;Sun & Zhang, 2005;Sun, Wu, & Deng, 2009;Wang et al, 2015;Wei, Liu, Huang, Tang, & Meng, 2005;Xing, Song, Hongjun, & Zhang, 2006;You, Huang, & Liu, 2007;Zhang, Cheng, Peng, Wang, & Peng, 2007;Zhang & Zhang, 2012;Zhou, Zhu, & Sun, 2007), two studies were from Italy (Flex et al, 2004;Pola et al, 2003), two studies from Egypt (Mohy, Ali, & Omar, 2015;Motawi, Shaker, Taha, & Abdel Raheem, 2012), one study was from the United States (Volcik, Ballantyne, Hoogeveen, Folsom, & Boerwinkle, 2010). Caucasian subjects were included in six studies (Flex et al, 2004;Geng, 2011;Mohy et al, 2015;Motawi et al, 2012;Pola et al, 2003;Volcik et al, 2010), black subjects were included in one (Volcik et al, 2010), and Asians were included in rest of the studies.…”

Section: Study and Patient Characteristicsmentioning

confidence: 99%

“…Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was most common form of genotyping. However, some studies used TaqMan PCR (Volcik et al, 2010), T-gradient PCR (Motawi et al, 2012), and TaKaRa PCR kits (Wang et al, 2015). Controls were population-based in the 16 studies but hospital based in four (Flex et al, 2004;Liu, 2005;Pola et al, 2003;Zhang et al, 2007).…”

Section: Study and Patient Characteristicsmentioning

confidence: 99%

Association between K469E polymorphism of ICAM‐1 gene and susceptibility of ischemic stroke: An updated meta‐analysis

Nepal

Yadav

Kong

2019

Molec Gen & Gen Med

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Background The intercellular adhesion molecule‐1 (ICAM‐1)/leukocyte function associated antigen‐1 (LFA‐1) adhesion system regulates leukocyte interactions, migration, and adhesion, and appears to play an important role in atherosclerosis and thrombosis. Therefore, single nucleotide polymorphisms (SNPs) of the ICAM‐1 gene may strongly influence the expression and biological activity of ICAM‐1 and play a potentially important role in the pathogenesis of ischemic stroke. In the current meta‐analysis, we investigated the relationship between the ICAM‐1 gene K469E SNP and the risk of ischemic stroke. Methods Two investigators independently searched PubMed, Web of Science, Google Scholar, WANFANG, China National Knowledge Infrastructure (CNKI) and J‐STAGE for studies published from January 2000 to February 2019 without language restriction. The association of K469E polymorphism and ischemic stroke in three genetic models (allelic, recessive, and dominant) were evaluated using Pooled odds ratios (ORs) with 95% confidence intervals (CIs). Results Our study included 20 studies from four continents and four different countries, including 3,137 cases and 15,382 controls. Meta‐analysis results did not show a significant association between K469E polymorphism of ICAM‐1 gene and ischemic stroke when assuming allelic model (OR: 1.12; 95% CI: 0.8 to 1.55; p = 0.51; I 2 = 93%) or recessive model (OR: 1.28; 95% CI: 0.89 to 1.84; p = 0.18; I 2 = 82%) or dominant model (OR: 1.20; 95% CI: 0.92 to 1.56; p = 0.17; I 2 = 85%). However, in all three genetic models, subgroup analysis revealed that the K469E polymorphism of the ICAM‐1 gene is associated with ischemic stroke in the Caucasian population. Conclusion K469E polymorphism of ICAM‐1 gene might be a risk factor for ischemic stroke in Caucasians, which suggested that K469E polymorphism might help in early identification of those at risk and help in primary prevention of ischemic stroke.

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Association of polymorphism in ICAM-1 (K469E) and cytology parameters in patients’ initial blood test with acute ischemic stroke

Cited by 9 publications

References 29 publications

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Association between K469E polymorphism of ICAM‐1 gene and susceptibility of ischemic stroke: An updated meta‐analysis

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