Association Of Polymorphism At The CD14 Promoter (CD14-C159T) With Atopic and Non-Atopic Asthma In Adults From Crimea, Ukraine

Bisyuk, Yuriy; Белоглазов, В. А.; Dubovyi, A. I.; Znamenska, L.K.; DuBuske, L.M.

doi:10.1016/j.jaci.2013.12.267

Cited by 1 publication

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“…TLR2 alleles have been demonstrated to be associated with a decrease in IgE in atopic children 28 . CD14 polymorphisms are associated with both atopic and non‐atopic asthma, and food allergy 29,30 . We did not explore single‐nucleotide polymorphisms in the present study, considering the sample size.…”

Section: Discussionmentioning

confidence: 97%

Children with nut allergies have impaired gene expression of Toll‐like receptors pathway

Poole

Song

O’Sullivan

et al. 2020

Pediatric Allergy Immunology

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Background Trends in food allergies prompted investigation into the underlying mechanisms. Genetic and epigenetic factors are of high interest, and, in particular, the interplay between genes relating to immune factors directly and indirectly involved in food allergy pathogenesis. We sought to determine potential links between gene expression and epigenetic factors relating to Toll‐like receptor (TLR) pathways and childhood food allergies. Methods In a cross‐sectional study, samples from 80 children with and without food allergies were analysed for gene expression, DNA methylation and a range of immune factors relating to TLR pathways. TLR2, TLR4, CD14, IL5, IL13 and vitamin D were explored. Results The importance of these immune factors appeared to vary between the different types of food allergies. Expression of TLR2 (P < .001), TLR4 (P = .014) and CD14 (P = .028) varied significantly between children with no food allergy, allergy to nuts and peanuts, and allergy to eggs. DNA methylation in the promoter regions of these genes had a significant association with gene expression. These trends persisted when subjects were stratified by nut allergy vs no nut allergy. Furthermore, TLR2 (P = .001) and CD14 (P = .007) expressions were significantly lower in children with food allergies when compared to those without. Conclusion Gene expression of TLR pathway genes was directly related to food allergy type, and DNA methylation had an indirect effect. TLR2 pathways are of significant interest in nut allergies.

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Section: Discussionmentioning

confidence: 97%