Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population

Osuch‐Wójcikiewicz, Ewa; Bruzgielewicz, Antoni; Niemczyk, Kazimierz; Sieniawska-Buccella, Olga; Nowak, Alicja; Walczak, Anna; Majsterek, Ireneusz

doi:10.1155/2015/298378

Cited by 29 publications

(13 citation statements)

References 56 publications

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“…It has been reported that the site of DICER1 rs13078 located in the 3′-UTR of the DICER1 gene and might be an important component in the expression process of the DICER1 gene by influencing the miRNAs binding site, which might impact the DICER1 enzyme's function by DICER1 gene regulation and sequentially impact the expression of microRNAs (52, 60, 61). Additionally, rs13078 genetic variants in DICER1 have been reported to be related to other diseases, such as gestational hypertension (62) and larynx cancer (63).…”

Section: Discussionmentioning

confidence: 99%

Association of Polymorphisms in miRNA Processing Genes With Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population

et al. 2019

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Objective: To evaluate the potential association between the genetic variants in miRNA processing genes ( RAN, XPO5, DICER1 , and TARBP2 ) and susceptibility to type 2 diabetes mellitus (T2DM) and its vascular complications, as well as to further investigate their interaction with environmental factors in type 2 diabetes. Methods: We conducted a case-control study in genotyping of five polymorphic loci, including RAN rs14035, XPO5 rs11077, DICER1 rs13078, DICER1 rs3742330, and TARBP2 rs784567, in miRNA processing genes to explore the risk factors for T2DM and diabetic vascular complications. Haplotype analyses, interactions of gene-gene and interactions of gene-environment were performed too. Results: We identified a 36% decreased risk of developing T2DM in individuals with the minor A allele in DICER1 rs13078 (OR: 0.64; 95%CI: 0.42–0.95; P : 0.026). The AA haplotype in DICER1 was also associated with a protective effect on T2DM compared with the AT haplotype (OR: 0.63; 95%CI: 0.42–0.94; P -value: 0.023). T2DM patients with the TT+TC genotype at RAN rs14035 had a 1.89-fold higher risk of developing macrovascular complications than patients with the CC genotype (OR: 1.89; 95%CI: 1.04–3.45; P -value: 0.037). We also identified two three-factor interaction models. One is a three-factor [ DICER1 rs13078, body mass index (BMI), and triglyceride (TG)] interaction model for T2DM (OR: 5.93; 95%CI: 1.25–28.26; P = 0.025). Another three-factor [ RAN rs14035, hypertension (HP), and duration of T2DM (DOD)] interaction model was found for macrovascular complications of T2DM ( OR = 41.60, 95%CI = 11.75–147.35, P < 0.001). Conclusion: Our study provides new evidence that two single nucleotide polymorphisms (SNPs) of the miRNA processing genes, DICER1 and RAN , and their interactions with certain environmental factors might contribute to the risk of T2DM and its vascular complications in the southern Chinese population.

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Section: Discussionmentioning

confidence: 99%

Association of Polymorphisms in miRNA Processing Genes With Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population

et al. 2019

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“…RAN is small Ras-related GTP-binding protein that plays an important role in the cell cycle. Specifically, RAN functions in the transport of molecules from the nucleus to the cytoplasm or from the cytoplasm to the nucleus through the nuclear pore complex, in a GTP-dependent manner [42]. In miRNA biology, RAN associates with a protein known as XPO5 to transport pre-miRNA precursors from the nucleus to the cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Association Between MicroRNA Biogenesis Gene Polymorphisms and Venous Thromboembolism in Koreans

Kim

et al. 2019

IJMS

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Venous thromboembolism (VTE) involves the formation of a blood clot, typically in the deep veins of the leg or arm (deep vein thrombosis), which then travels via the circulatory system and ultimately lodges in the lungs, resulting in pulmonary embolism. A number of microRNAs (miRNAs) are well-known regulators of thrombosis and thrombolysis, and mutations in miRNA biogenesis genes, such as DICER1, DROSHA have been implicated in miRNA synthesis and function. We investigated the genetic association between polymorphisms in four miRNA biogenesis genes, DICER1 rs3742330A > G, DROSHA rs10719T > C, RAN rs14035C > T and XPO5 rs11077A > C, and VTE in 503 Koreans: 300 controls and 203 patients. Genotyping was assessed with polymerase chain reaction-restriction fragment length polymorphism assays. We detected associations between polymorphisms in RAN and XPO5 and VTE prevalence (RAN rs14035CC + CT versus TT: p = 0.018; XPO5 rs11077AA + AC versus CC: p < 0.001). Analysis of allele combinations of all four polymorphisms (DICER1, DROSHA, RAN, XPO5) revealed that A-T-T-A was associated with decreased VTE prevalence (p = 0.0002), and A-T-C-C was associated with increased VTE prevalence (p = 0.027). Moreover, in subjects with provoked VTE, the DROSHA rs10719T > C, polymorphism was associated with increased disease prevalence (TT versus TC + CC: p < 0.039). Our study demonstrates that RAN and XPO5 polymorphisms are associated with risk for VTE in Korean subjects.

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“…Since they are often located within non-coding regions, their functional significance is not always clear. The discovery of miRs and their ability to bind the 3′-UTR of target genes, is providing a functional explanation of how some SNPs, positioned in non-coding regions, could contribute to cancer susceptibility, with data emerging that miR SNPs are associated with many cancers such as breast cancer [29], gynaecological malignancy [30], lung cancer [31], laryngeal cancer [32], and others. Such genetic variants may alter miR processing and/or target selection, likely contributing to cancer susceptibility and disease progression.…”

Section: Discussionmentioning

confidence: 99%

Differential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities

et al. 2018

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Introduction: Breast cancer outcomes vary across different ethnic groups. MicroRNAs (miRs) are small non-coding RNA molecules that regulate gene expression across a range of pathologies, including breast cancer. The aim of this study was to evaluate the presence and expression of miRs in breast cancer samples from different ethnic groups. Materials and Methods: Breast cancer tissue from 4 ethnic groups, i.e., British Caucasian, British Black, Nigerian, and Indian, were identified and matched for patients’ age, tumour grade/type, and 10 × 10 µm sections taken. Tumour areas were macrodissected, total RNA was extracted, and cDNA was synthesised. cDNA was applied to human miScript PCR arrays allowing the quantification of 84 of the most abundantly expressed/best-characterised miRs. Results: Differential expression of 9 miRs was seen across the 4 groups. Significantly higher levels of miR-140-5p, miR-194 and miR-423-5p (the last of which harbours the single-nucleotide polymorphism rs6505162) were seen in the breast tumours of Nigerian patients when compared with other ethnic groups (all p < 0.0001). miR-101 was overexpressed in breast cancers in the Indian patients. An in silico analysis of miR-423-5p showed that the AC genotype is mainly associated with Europeans (57%), while Asians display mostly CC (approx. 60%), and Africans mainly AA (approx. 60%). Conclusions: This study shows divergence in miR expression in breast cancers from different ethnic groups, and suggests that specific genetic variants in miR genes may affect breast cancer risk in these groups. Predicted targets of these miRs may uncover useful biomarkers that could have clinical value in breast cancers in different ethnic groups.

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Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population

Cited by 29 publications

References 56 publications

Association of Polymorphisms in miRNA Processing Genes With Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population

Association of Polymorphisms in miRNA Processing Genes With Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population

Analysis of the Association Between MicroRNA Biogenesis Gene Polymorphisms and Venous Thromboembolism in Koreans

Differential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities

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