Abstract:ImportanceAlthough more than 200 genes have been associated with monogenic congenital hearing loss, the polygenic contribution to hearing decline across the life course remains largely unknown.ObjectiveTo examine the association of polygenic risk scores (PRSs) for self-reported hearing difficulty among adults (40-69 years) with measured hearing and speech reception abilities in mid-childhood and early midlife.Design, Setting, and ParticipantsThis was a population-based cross-sectional study nested within the L… Show more
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