Association of Plasminogen with Dipeptidyl Peptidase IV and Na+/H+ Exchanger Isoform NHE3 Regulates Invasion of Human 1-LN Prostate Tumor Cells

Gonzalez-Gronow, Mario; Misra, U. K.; Gawdi, Govind; Pizzo, Salvatore V.

doi:10.1074/jbc.m500383200

Cited by 22 publications

(17 citation statements)

References 48 publications

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“…These proteins have been found in PE3334 and may mask sCD26-attractin. However, further study is warranted by previous findings that CD26/DPP-IV acts as receptor for plasminogen type 23536 and that alpha-2-macroglobulin inactivates serine-proteases and also inhibits fibrinolysis via inhibition of plasmin37.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease

Sánchez-Otero

Rodrı́guez-Berrocal

Cadena

et al. 2014

Sci Rep

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In this study, we measured ADA and DPP-IV enzymatic activity and sCD26 concentration in 150 pleural effusion (PE) samples and tested for correlations between these and other cellular and biochemical measures. We found that DPP-IV in particular might improve the specificity (but not the sensitivity) of the ADA test for diagnosis of pulmonary tuberculosis, since half of the false ADA positive results in non-tuberculous PE were also DPP-IV positive. A percentage of patients with malignant PE were sCD26 or DPP-IV positive; however, some patients with benign PE also tested positive. As a pattern associated with DPP-IV (but not the CD26 protein) was observed in PE, we searched for a finding that might increase the value of these biomarkers for diagnosis of malignancy. The observed pattern was related to the presence of leukocytes, as indicated by correlations with the cell count, and to a band of 180 kDa, detected by immunoblotting.

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Section: Discussionmentioning

confidence: 99%

Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease

Sánchez-Otero

Rodrı́guez-Berrocal

Cadena

et al. 2014

Sci Rep

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“…Pg 2 binding to DPPIV in this cell type induces an intracellular calcium signaling cascade that is accompanied by a rise in intracellular pH. The authors postulated that the interaction of Pg 2 with DPPIV and NHE3 has the potential to regulate simultaneously calcium signaling and Na ϩ -H ϩ exchange necessary to tumor cell invasiveness (14). Preliminary studies from overlay experiments demonstrate that NHE3 and DPPIV do not bind directly to each other in renal brush-border membranes, indicating that additional accessory proteins are required for this association to occur (13).…”

Section: Discussionmentioning

confidence: 99%

Dipeptidyl peptidase IV inhibition downregulates Na⁺-H⁺exchanger NHE3 in rat renal proximal tubule

Girardi

Fukuda²,

Rossoni³

et al. 2008

American Journal of Physiology-Renal Physiology

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“…On the other hand, the DPP4-FAP complex, with both prolyl peptidase activity and gelatinase activity, facilitates the local degradation of the extracellular matrix and the invasion of the endothelial cells into collagenous matrices [43]. In addition, the association of plasminogen type II (Pg2) with DPP4 and Na + /H + exchanger isoform 3 has the potential to simultaneously regulate calcium signalling pathway and Na + /H + exchanges necessary for tumor cell proliferation and invasiveness [44].…”

Section: Other Extraenzymatic Functions Of Dpp4mentioning

confidence: 99%

Dipeptidyl Peptidase-4 (CD26): Knowing the Function before Inhibiting the Enzyme

Matteucci

Giampietro

2009

CMC

174

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Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 (EC 3.4.14.5.) is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types, whose physiological functions are largely unknown. Protein dimerisation should be required for catalytic activity and glycosylation of the enzyme could impact on its physiological functions. The dimeric glycoprotein ADCP has been found linked to adenosine deaminase (ADA) whose relationship with lymphocyte maturation-differentiation is well-established. Since implicated in the regulation of the biological activity of hormones and chemokines, such as glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, DPP4 inhibition offers a new potential therapeutic approach for type 2 diabetes mellitus, as monotherapy and adjunct therapy to other oral agents. The clinical use of presently available orally active inhibitors of DPP4, however, has been associated with side effects that have been in part attributed to the inhibition of related serine proteases, such as DPP8 and DPP9. Indeed, it is noteworthy that CD26 has a key role in immune regulation as a T cell activation molecule and in immune-mediated disorder. All-cause infections were increased after sitagliptin treatment. It is noteworthy that the effects of DPP4 inhibition on the immune system have not been extensively investigated. So far, only routine laboratory safety variables have been measured in published randomised controlled trials. The review summarises present knowledge in the field and suggests some potential directions of future research.

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Association of Plasminogen with Dipeptidyl Peptidase IV and Na+/H+ Exchanger Isoform NHE3 Regulates Invasion of Human 1-LN Prostate Tumor Cells

Abstract: Binding of plasminogen type II (Pg 2) to dipeptidyl peptidase IV (DPP IV)

Cited by 22 publications

References 48 publications

Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease

Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease

Dipeptidyl peptidase IV inhibition downregulates Na⁺-H⁺exchanger NHE3 in rat renal proximal tubule

Dipeptidyl Peptidase-4 (CD26): Knowing the Function before Inhibiting the Enzyme

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Association of Plasminogen with Dipeptidyl Peptidase IV and Na+/H+ Exchanger Isoform NHE3 Regulates Invasion of Human 1-LN Prostate Tumor Cells

Abstract: Binding of plasminogen type II (Pg 2) to dipeptidyl peptidase IV (DPP IV)

Cited by 22 publications

References 48 publications

Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease

Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease

Dipeptidyl peptidase IV inhibition downregulates Na+-H+exchanger NHE3 in rat renal proximal tubule

Dipeptidyl Peptidase-4 (CD26): Knowing the Function before Inhibiting the Enzyme

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Dipeptidyl peptidase IV inhibition downregulates Na⁺-H⁺exchanger NHE3 in rat renal proximal tubule