Association of plasminogen activator inhibitor-1 with insulin resistance in Japan where obesity is rare

Nakamura, Tomohisa; Adachi, Hisashi; Hirai, Yuji; Satoh, Akira; Ohuchida, Masanao; Imaizumi, Tsutomu

doi:10.1053/meta.2003.50027

Cited by 15 publications

(7 citation statements)

References 25 publications

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“…Adiponectin regulates glucose and fatty acid oxidation [27], chronic elevation of IL-6 promotes hepatic insulin resistance [28] while acute elevation of IL-6 promotes the supply of glucose and fat to skeletal muscle [29]. IL-8 is correlated with insulin resistance in obesity and metabolic syndrome [30,31] while PAI-1 is associated increased visceral fat mass [32] and insulin resistance in lean individuals [33]. Lipocalin-2 is associated with increased total energy expenditure and increased fat oxidation [34], and TNFα induces lipolysis [27].…”

Section: Discussionmentioning

confidence: 99%

Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis

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Steyn

Huang

et al. 2015

Journal of the Neurological Sciences

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Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the loss of upper cortical and lower motor neurons. ALS causes death within 2-5years of diagnosis. Diet and body mass index influence the clinical course of disease, however there is limited information about the expression of metabolic proteins and fat-derived cytokines (adipokines) in ALS. In healthy controls and subjects with ALS, we have measured levels of proteins and adipokines that influence metabolism. We find altered levels of active ghrelin, gastric inhibitory peptide (GIP), pancreatic polypeptide (PP), lipocalin-2, plasminogen activator inhibitor-1 (PAI-1), interleukin-6 (IL-6) and 8 (IL-8), and tumor necrosis factor alpha (TNFα) in the plasma of ALS patients relative to controls. We also observe a positive correlation between the expression of plasma nerve growth factor (NGF) relative to disease duration, and an inverse correlation between plasma glucagon and the ALS functional rating scale-revised (ALSFRS-R). Further studies are required to determine whether altered expression of metabolic proteins and adipokines contribute to motor neuron vulnerability and how these factors act to modify the course of disease.

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Section: Discussionmentioning

confidence: 99%

Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis

Ngo

Steyn

Huang

et al. 2015

Journal of the Neurological Sciences

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“…PAI-1 concentrations are directly influenced by insulin (44), even in situations of insulin resistance (45), a fact that has been explained in terms of abdominal fat, via a higher concentration of cytokines in subjects with central obesity (41). Nevertheless, the association of PAI-1 and insulin resistance has also been found in nonobese cohorts (46). These apparently contradictory findings may be partially explained by the identification of a regulatory element (AP-1 response element) in the PAI-1 promoter.…”

Section: Discussionmentioning

confidence: 99%

Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients

Ruano

López‐Miranda

Torre

et al. 2007

The American Journal of Clinical Nutrition

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Background: Oxidative stress associated with postprandial lipemia contributes to endothelial dysfunction, which shifts hemostasis to a more thrombogenic state. Objective: We investigated whether a high concentration of phenols in olive oil can partly reverse this phenomenon. Design: Twenty-one hypercholesterolemic volunteers received 2 breakfasts rich in olive oils with different phenolic contents (80 or 400 ppm) according to a randomized, sequential crossover design. Plasma concentrations of lipid fractions, factor VII antigen (FVIIag), activated factor VII (FVIIa), and plasminogen activator inhibitor-1 (PAI-1) activity were measured at baseline and postprandially. Results: Concentrations of FVIIa increased less (P ҃ 0.018) and plasma PAI-1 activity decreased more (P ҃ 0.021) 2 h after the high-phenol meal than after the low-phenol meal. FVIIa concentrations 120 min after intake of the olive oil with a high phenol content correlated positively with fasting plasma triacylglycerols (P ҃ 0.001), area under the curve (AUC) of triacylglycerols (P ҃ 0.001), and AUC of nonesterified fatty acids (P ҃ 0.024) and negatively with hydroxytyrosol plasma concentrations at 60 min (P ҃ 0.039) and fasting HDL-cholesterol concentrations (P ҃ 0.005). PAI-1 positively correlated with homeostasis model assessment of insulin resistance (P ҃ 0.005) and fasting triacylglycerols (P ҃ 0.025) and inversely with adiponectin (P ҃ 0.026). In a multivariate analysis, the AUCs of nonesterified fatty acids (R 2 ҃ 0.467; ␤: 0.787; SE: 0.02; P 0.001) and adiponectin (R 2 ҃ 0.232; ␤: Ҁ1.594; SE: 0.629; P 0.05) were the strongest predictors of plasma FVIIa and PAI-1, respectively.

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“…Increased concentrations of interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) have been associated with an increased risk of T2DM [3,4]. Elevated plasminogen activator inhibitor type 1 (PAI-1) has also been found to be a predictor of the development of T2DM [5,6,7,8]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Two Different Dietary Patterns on Inflammatory Markers, Advanced Glycation End Products and Lipids in Subjects without Type 2 Diabetes: A Randomised Crossover Study

2017

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Epidemiological studies suggest that consumption of red and processed meat and refined grains are associated with type 2 diabetes and metabolic syndrome and increased inflammatory and fibrinolytic markers. We hypothesised that a diet high in red and processed meat and refined grains (HMD) would increase inflammatory markers and advanced glycation end products (AGEs) compared with a diet high in dairy, whole grains, nuts and legumes (HWD). We performed a randomised crossover study of two four-week interventions in 51 participants without type 2 diabetes (15 men and 36 women aged 35.1 ± 15.6 years; body mass index: 27.7 ± 6.9 kg/m2). No baseline measurements were performed. Plasma fluorescent AGEs, carboxymethyllysine, glucose, insulin, lipids, hs-CRP, interleukin 6 (IL-6) and plasminogen activator inhibitor-1 (PAI-1) were analysed after four weeks on each diet. IL-6, hs-CRP, AGEs and carboxymethyllysine were not different between diets but PAI-1 was higher after the HMD than after HWD ((median and interquartile range) 158, 81 vs. 121, 53 ng/mL p < 0.001). PAI-1 on the HWD diet was inversely correlated with whole grains intake (p = 0.007). PAI-1 was inversely correlated with insulin sensitivity index (r = −0.45; p = 0.001) and positively correlated with serum total cholesterol (r = 0.35; p = 0.012) and serum triglyceride (r = 0.32; p = 0.021) on HMD. This trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12614000519651).

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Association of plasminogen activator inhibitor-1 with insulin resistance in Japan where obesity is rare

Cited by 15 publications

References 25 publications

Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis

Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis

Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients

Effects of Two Different Dietary Patterns on Inflammatory Markers, Advanced Glycation End Products and Lipids in Subjects without Type 2 Diabetes: A Randomised Crossover Study

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