Association of plasminogen activator inhibitor-1 genotype with avascular osteonecrosis in steroid-treated renal allograft recipients1

Ferrari, Paolo; Schroeder, Verena; Anderson, Suzanne E.; Kocovic, Leonardo; Vogt, Bruno; Schiesser, Daniela; Marti, Hanspeter; Ganz, Reinhold; Frey, Felix J.; Köhler, Hans Peter

doi:10.1097/00007890-200210270-00016

Cited by 63 publications

(48 citation statements)

References 29 publications

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“…Genotyping of the TPA gene Alu-repeat (I/D polymorphism in intron 8 of the TPA gene were genotyped by a polymerase chain reaction (PCR) [16]. Synthetic oligonucleotides obtained from TIB MOLBIOL Syntheselabor (Berlin, Germany) were used.…”

Section: Biochemical Assaymentioning

confidence: 99%

4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome

Karadeniz

Erdoğan

Berdelı

et al. 2007

J Assist Reprod Genet

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Purpose Polycystic ovary syndrome (PCOS) is one of the most encountered endocrine malfunctions. PCOS patients have enhanced activation of the blood coagulation system. Methods Eighty-six young women with PCOS and 70 healthy control women were included in our study. PCOS patients and controls were matched for age, body mass index, and allele frequency. Genetic analysis of TPAI and PAI-1 were performed in all subjects. Results and conclusions No statistically significant differences have been detected about the ratios of genotypes resulting from PAI-1 promotor 4G/5G gene polymorphism. PAI-1 765 4G/5G gene polymorphism and TPA gene's Alurepeat insertion/deletion (I/D) polymorphism ratios were not different from the controls. In this study it is shown by the analysis of TPA gene's Alu-repeat insertion/deletion (I/D) polymorphism the PCOS patients with genotype II had lowers total cholesterol and LDL-cholesterol levels.

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Section: Biochemical Assaymentioning

confidence: 99%

4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome

Karadeniz

Erdoğan

Berdelı

et al. 2007

J Assist Reprod Genet

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“…The majority of association studies relating to osteonecrosis have concentrated on gene polymorphisms affecting the coagulation and fibrinolytic systems [6]. However, the association between genetic predisposition and thrombotic tendency may differ between ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Endothelial nitric oxide synthase gene polymorphisms and the risk of osteonecrosis of the femoral head in systemic lupus erythematosus

Kim

Bae

Kim

et al. 2013

International Orthopaedics (SICOT)

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“…[3][4][5][6] However, the relationship of genetic polymorphism of plasminogen activator inhibitor (PAI)-1 4G/5G and post-renal transplant FHON was controversial. 3,5 Nitric oxide (NO) is a multifunctional biomolecule and serves as an important signal in physiologic processes including angiogenesis, thrombosis, and bone turnover, which are known to be related to the pathogenesis of osteonecrosis. 7 It was reported that the predominant isoform of nitric oxide synthases expressed in normal adult bone is endothelial nitric oxide synthase (eNOS).…”

Section: Introductionmentioning

confidence: 99%

Endothelial nitric oxide synthase gene polymorphisms in patients with nontraumatic femoral head osteonecrosis

Koo

Lee

et al. 2006

Journal Orthopaedic Research

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As endothelial nitric oxide synthase (eNOS) has beneficial effects on skeletal, vascular, and thrombotic systems, the association between nontraumatic femoral head osteonecrosis (FHON) and eNOS gene polymorphisms was investigated in Korean patients with FHON. Genomic DNA from 103 patients with nontraumatic FHON (idiopathic in 50, steroid-induced in 29, and alcohol abuse in 24) and 103 control subjects matched for gender and age (3-year range) was analyzed for the 27-bp repeat polymorphism in intron 4 and Glu298Asp polymorphism in exon 7. The frequencies of alleles and genotypes were compared between patients and control subjects. The frequency of 4a allele was significantly higher in total patients than control subjects [6.8% vs. 2.4%, p ¼ 0.0345, odds ratio (OR) 2.931]. In subgroup analysis, the 4a allele significantly increased in patients with idiopathic FHON versus control subjects (9.0% vs. 2.4%, p ¼ 0.0297, OR 3.976). The frequency of the 4a/b genotype in total patients (13.6% vs. 4.9%, p ¼ 0.0302, OR 3.083) as well as patients with idiopathic FHON (18.0% vs. 4.9%, p ¼ 0.0246, OR 4.302) was higher than control subjects. The distribution of Glu298Asp polymorphisms was not significantly different between patients and control subjects. Microstellate polymorphism in intron 4 of eNOS polymorphism was significantly associated with idiopathic FHON in Korean patients. Because 4a allele is associated with lower synthesis of eNOS, these results suggest that carrier state of 4a allele in intron 4 might be a genetic risk factor of FHON and could provide insight into the protective role of nitric oxide in the pathogenesis of FHON. ß

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Association of plasminogen activator inhibitor-1 genotype with avascular osteonecrosis in steroid-treated renal allograft recipients1

Cited by 63 publications

References 29 publications

4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome

4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome

Endothelial nitric oxide synthase gene polymorphisms and the risk of osteonecrosis of the femoral head in systemic lupus erythematosus

Endothelial nitric oxide synthase gene polymorphisms in patients with nontraumatic femoral head osteonecrosis

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