Association of Plasma Vitamin B6 With Coronary Heart Disease in Patients Undergoing Diagnostic Coronary Angiography: New Insight on Sex Differences

Abstract

Aim: To date, findings on the overall and sex-specific effects of plasma pyridoxal 5′-phosphate (PLP, active coenzyme form of vitamin B6) on the risk of coronary heart disease (CHD) have been inconsistent. This study sought to advance our understanding on the association of plasma PLP with risk of CHD, with particular attention paid to sex differences and effect modifiers.Methods: We conducted a hospital-based, case-control study on suspected CHD patients undergoing diagnostic coronary angiography. A total of 429 CHD cases and 429 controls matched by age, sex, and operation time were included in the final analysis. Plasma PLP was assessed using LC-MS. Logistic regression analyses were performed to evaluate the association between plasma PLP and a first CHD event.Results: The mean (SD) plasma PLP levels were 8.4 (6.3) in male cases and 9.0 (11.0) in female cases, and 9.5 (8.5) in male controls and 12.5 (12.9) in female controls. Each 1 ng/mL increment in log2PLP was associated with a 28% lower risk of CHD in overall population. When stratified by sex, plasma PLP was significantly and independently associated with CHD in women (OR = 0.63, 95% CI: 0.50–0.80), but not in men (OR = 0.86, 95% CI: 0.67–1.09). The association of plasma PLP with CHD risk was modified by sex (adjusted Pinteraction = 0.022).Conclusions: We found a significant, inverse linear association between plasma PLP and CHD in Chinese women, but not in men. Our findings warrant additional investigation.

The gut microbiome across the cardiovascular risk spectrum

“…Previous studies have reported significant associations between low vitamin B6 levels and increased risk of coronary heart disease. More specifically, a significant inverse linear relation of plasma pyridoxal 5'phosphate (the active coenzyme form of vitamin B6) levels and risk of coronary heart disease in women has been reported 34 . However, it should be emphasized that the decreased abundance of this pathway in the STEMI group is for the microbial metabolic pathway not the human pathway.…”

Early detection of stroke at the sudden sensorineural hearing loss stage

“…The detailed definitions of the six risk factors for stroke mentioned above are as follows: x hypertension, indicated by a history of high blood pressure with a measurement of ≥140/90 mmHg as reported by the individual or diagnosed by a physician (14); ydiabetes, indicated by fasting plasma glucose levels of ≥7.0 mmol/L or taking glucose-lowering drugs (15); z dyslipidaemia, deemed either self-reported physiciandiagnosed hyperlipidaemia or the use of lipid-lowering drugs (16); {stroke history, characterized by the sudden onset of focal neurologic deficits and diagnosed as either ischemic or haemorrhagic stroke; and |smoking history, defined as smoking at least 1 cigarette per day for >6 months before admission (17); and }drinking history, defined as consuming more than 100 ml of spirit alcohol more than three times a week based on self-report (18). Furthermore, accompanying symptoms and laboratory test results were also recorded.…”