Association of plasma triglyceride-rich lipoprotein remnants with coronary atherosclerosis in cases of sudden cardiac death

Takeichi, Sanae; Yukawa, Nobuhiro; Nakajima, Yasuhiro; Osawa, Motoki; Saito, Takeshi; Seto, Yoshihisa; Nakano, Takamitsu; Saniabadi, Abby R.; Adachi, Masakazu; Wang, Tao; Nakajima, Katsuyuki

doi:10.1016/s0021-9150(98)00246-9

Cited by 80 publications

(51 citation statements)

References 25 publications

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“…Associations of RLP-Clevels with coronary events have recently been reported (24,25). Wehave previously reported that RLP-C levels are markedly high in patients who have established coronary artery stenosis (26).…”

Section: Discussionmentioning

confidence: 96%

Predictive Value of Remnant-like Particle Cholesterol as an Indicator of Coronary Artery Stenosis in Patients with Normal Serum Triglyceride Levels.

et al. 2000

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Objective Wedesigned the present study to evaluate the association of various lipid and fibrinolytic components with coronary artery stenosis with respect to the triglyceride (TG) level.Methods Levels of TG, remnant-like particle cholesterol (RLP-C), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), lipoprotein-(a), uric acid, blood glucose, tissue plasminogen activator (t-PA), t-PA inhibitor type 1, antithrombin III, and protein C were measured in 208 patients who underwent diagnostic coronary angiograms.Patients Of these 208 patients, 59 were hypertriglyceridemic (150 mg/dl or higher) and 149 were normotriglyceridemic.Results Both LDL-Cand HDL-Cshowed significant differences between patients with and those without coronary artery stenosis in both hypertriglyceridemic and normotriglyceridemic patient subgroups. However, RLP-C showeda significant difference in the normotriglyceridemic patient subgroup (p=0.012) but not in the hypertriglyceridemic patient subgroup (p=0.736). Conclusion Our current retrospective study disclosed that RLP-Clevels are closely associated with coronary artery stenosis in patients with normal TGlevels.

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Section: Discussionmentioning

confidence: 96%

Predictive Value of Remnant-like Particle Cholesterol as an Indicator of Coronary Artery Stenosis in Patients with Normal Serum Triglyceride Levels.

et al. 2000

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“…Increased levels of nonfasting triglycerides may indicate the presence of increased levels of atherogenic remnant lipoproteins (7,8,23). Some experimental (24,25) and clinical studies (8,26,27) Table 4. Fasting and postprandial triglyceride levels for CAD patients and controls in patients with and without fasting triglyceride elevation remnant particles might contribute to atherosclerosis and postprandial hypertriglyceridemia, reflecting an elevated concentration of lipoprotein remnant particles, might therefore indicate increased risk for myocardial infarction, ischemic heart disease, and death.…”

Section: Discussionmentioning

confidence: 99%

Is there any relationship between coronary artery disease and postprandial triglyceride levels?

Atar¹,

Atar²,

Aydınalp³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Biz bu çalışmada, tokluk trigliserid (TTG) düzeyi ve koroner arter hastalığı (KAH) arasındaki ilişkiyi araştırmayı amaçladık. Yöntemler: Bu prospektif kohort çalışmasına toplam 80 hasta dahil edildi ve TTG düzeyini ölçmek için ağızdan lipit yüklemesi yapıldı. Aç olarak ve lipitten zengin bir kahvaltı sonrası 2., 4., 6. ve 8. saatte tok olarak trigliserid düzeyi enzimatik yöntemle ölçüldü. Açlık trigliserid yüksekliği olan ve olmayan bireylerde lipit yüklemesinin trigliserid düzeyi üzerine etkisinin değerlendirilmesi için alt grup analizi uygulandı. Lipid yüklemesi sonrası trigliserid düzeyleri ve trigliserid düzeyindeki yüzde değişim oranları "tekrarlayan değerler için genel lineer model" analizi ile değerlen-dirildi. Örneklem büyüklüğü hesaplandı. Bulgular: Başlangıçtaki klinik, demografik ve biyokimyasal ölçümlerin sonuçları gruplar arasında benzerdi. Her iki grupta da zirve trigliserid seviyesi lipit yüklemesi sonrası 4. saatteydi. Lipit yüklemesi sonrası her iki grupta da trigliserid düzeyleri başlangıca göre anlamlı olarak arttı (p<0.001) ancak bu değişimler iki grup arasında farklı değildi (p=0.279). Alt grup analizlerinde; açlık trigliserid yüksekliği olan alt grupta, trigliserid düzeyi eğrisi altında kalan alanda KAH grubunda kontrol grubuna göre anlamlı yükseklik vardı (334±103 vs. 233±58 mg/dl, p=0.02). Sonuç: Bizim sonuçlarımız, açlık trigliserid düzeyi yüksek olan hastalarda TTG yüksekliğinin KAH ile ilişkili olabileceğini, ancak açlık trigliserid düzeyi yüksek olmayan hastalarda TTG düzeyi ile KAH arasında bir ilişki olmadığını göstermektedir. ABSTRACTObjective: We aimed to evaluate the relationship between postprandial triglyceride (PPTG) levels and coronary artery disease (CAD). Methods: A total of 80 patients were included in this prospective cohort study. Oral lipid loading was used in order to measure PPTG levels. In the fasting state and after the high fat breakfast, triglyceride levels were measured by enzymatic methods at 2 nd , 4 th , 6 th and 8 th hours. We made subgroup analysis to show the effects of lipid loading on triglyceride levels in patients with and without fasting hypertriglyceridemia. We evaluated triglyceride levels and changes of triglyceride levels in percentages after lipid loading using a general linear model for repeated measures. Sample size analysis was performed. Results: Baseline clinical, demographic and laboratory characteristics of both groups were similar. The peak triglyceride levels were seen at the 4 th hour in both groups. Triglyceride levels were significantly increased after lipid-rich-breakfast loading compared to baseline levels in both groups (p<0.001) but these changes were not significant (p=0.279). In patients with elevated fasting triglyceride levels, the area under the plasma triglyceride concentration curve was significantly larger in CAD group than control group (334±103 vs. 233±58 mg/dl, p=0.02). Conclusion: Our data show that in patients who have a high fasting triglyceride level, high levels of PPTG may be related to CAD, however high...

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“…ing that an increase of RLP-C is a risk factor for atherosclerosis 22,23) . The Framingham Heart Study showed that an increase of RLP-C is a significant risk factor for cardiovascular disease in women 24) .…”

Section: Discussionmentioning

confidence: 99%

Influence of Aging and Menopause on Postprandial Lipoprotein Responses in Healthy Adult Women

Nabeno

Fukuchi

Matsutani

et al. 2007

J Atheroscler Thromb

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Association of plasma triglyceride-rich lipoprotein remnants with coronary atherosclerosis in cases of sudden cardiac death

Cited by 80 publications

References 25 publications

Predictive Value of Remnant-like Particle Cholesterol as an Indicator of Coronary Artery Stenosis in Patients with Normal Serum Triglyceride Levels.

Predictive Value of Remnant-like Particle Cholesterol as an Indicator of Coronary Artery Stenosis in Patients with Normal Serum Triglyceride Levels.

Is there any relationship between coronary artery disease and postprandial triglyceride levels?

Influence of Aging and Menopause on Postprandial Lipoprotein Responses in Healthy Adult Women

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