Association of plasma level of malondialdehyde-modified low-density lipoprotein with coronary plaque morphology in patients with coronary spastic angina: Implication of acute coronary events

Tani, Shigemasa; Nagao, Ken; Anazawa, Takeo; Kawamata, Hirofumi; Furuya, Shinichi; Fuji, T; Takahashi, Hiroshi; Iida, Kiyoshi; Matsumoto, Michiaki; Kumabe, Takamichi; Sato, Yuichi; Hirayama, Atsushi

doi:10.1016/j.ijcard.2008.03.071

Cited by 12 publications

(9 citation statements)

References 19 publications

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“…Recently, our group showed that Lipofundin induces LPO and a depletion of antioxidant substances in rabbits [3,17]. LPO induces disturbance of cell structures, alteration of integrity, fluidity, and permeability, and functional loss of biomembranes, modifies low density lipoproteins (LDL) to proatherogenic and proinflammatory forms, and generates potentially toxic products such as MDA and lipoperoxides [18]. The MDA levels were positively modified by Vimang, as well as vitamins treatment.…”

Section: Discussionmentioning

confidence: 99%

“…This is an important fact, because high serum levels of MDA represent a predictor of atherosclerosis and other pathological diseases [3]. Martínez et al demonstrated that this natural product inhibited the formation of MDA in brain and hepatic ischemic damage [18,19]. In this paper the authors suggest that the main mechanism responsible of LPO inhibition may be associated with • OH radical scavenging properties of the mango extract [20], since • OH radicals are considered major promoter of LPO in vitro and in vivo [21].…”

Section: Discussionmentioning

confidence: 99%

“…Lipid hydroperoxides in the presence or absence of catalytic metal ions also give rise to a large variety of products, including short chain aldehydes, which can be used to assess the degree of LPO in a system [22]. Many natural products are able to inhibit the lipoperoxides formation [18]; indeed we demonstrated that extract inhibited the in vivo formation of TH, and we thought that aqueous extract is able to abrogate the formation of this reactive molecules mainly through its capacity to scavenge • OH and other ROS.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Mangifera indica L. Extract Against Lipofundininduced Oxidative Stress in Rats

Roche¹

2012

TOPHARMCJ

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Lipofundin is a lipid rich emulsion used in parenteral nutrition. It is known that Lipofundin induces an oxidative stress state characterized by an increase of lipid peroxidation and a dramatic depletion of antioxidants. The aim of the present study was to evaluate the effects of an aqueous extract of Mangifera indica L., on Lipofundin-induced oxidative stress. Male Sprague Dawley rats were treated orally with 200 mg/kg of Vimang®, followed by an intravenous dose of 2 mL/kg Lipofundin, daily, for 8 days. Selected oxidative stress biomarkers were then measured spectrophotometrically. The results showed that Vimang® produced significant (p<0.05) reduction of malondialdehyde, total hydroperoxides and advanced oxidation protein products, while the activities of superoxide dismutase and catalase were positively modulated. A significant (p<0.05) reduction of peroxidation potential and a preservation of glutathione and total antioxidant status was also observed. Our data demonstrated that Vimang® protects against Lipofundin-induced oxidative stress, which is an important finding that further reinforces the antioxidant properties of this natural product.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Mangifera indica L. Extract Against Lipofundininduced Oxidative Stress in Rats

Roche¹

2012

TOPHARMCJ

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“…Считается, что повышение этого показателя является предиктором атеротромбоза [18]. Помимо этого, некоторые работы [3] подтверждают, что по динамике МДА можно контролировать эффектив-ность терапии хронической ИБС.…”

Section: окисляемость липидов в плазме крови у пациентов с острым корunclassified

Lipid peroxidation end products in patients with acute coronary syndrome

Bykova¹,

Dumikjan²,

Азизова³

et al. 2015

Kardiol. serdechno-sosud. khir.

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“…In AMI patients, both PGM activity and creatine kinase (CK) were measured until the level of CK peaked out in order to clarify the relationship between PGM activity and CK. To evaluate coronary risk factors, the levels of estimated glomerular filtration rate (eGFR), 15 TG, HDL-C, low-density lipoprotein cholesterol (LDL-C), 16 the ratio of eicosapentaenoic acid and arachidonic acid, 17 malonyldialdehyde LDL, 18 and hemoglobin A1c (HbA1c) were examined on admission. To compare PGM activity and well-established biomarkers including myocardial biomarkers (cardiac troponin T (TnT), 1 heart-type fatty acid-binding protein (H-FABP), 1 CK, CKMB, and aspartate aminotransferase (AST)), thrombosis biomarkers (d-dimer 19 and total plasminogen-activator inhibitor type 1 (PAI-1) 2 ), and inflammatory biomarkers (C-reactive protein (CRP) 20 and plasma pentraxin 3 (PTX3) 21 ) were also examined on admission.…”

Section: Blood Sampling Proceduresmentioning

confidence: 99%

Phosphoglucomutase Activity as a Novel Biomarker in Patients With Acute Myocardial Infarction

Nishinari

Aoyama

Ogawa

et al. 2012

Circ J

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Background: Phosphoglucomutase (PGM), a key enzyme in cellular glucose utilization and energy homeostasis, has been reported to show a relationship with oxidative stress. However, the clinical importance of PGM activity has not been investigated in patients with ischemic heart disease (IHD). The aim of the present pilot study was to clarify whether PGM activity has potential as a cardiovascular risk predictor in patients with IHD. Methods and Results:The levels of serum PGM activity in 237 patients with IHD (63 patients with acute myocardial infarction (AMI) and 174 patients with stable effort angina pectoris (EAP)) were evaluated. PGM activity was compared with levels of various myocardial, thrombosis, and inflammatory biomarkers on admission. PGM activity in the AMI group was significantly increased relative to that in the EAP group on admission (AMI, 55.5 μmol · min -1 · L -1 (U/L); EAP, 14.4 U/L (P<0.001)), and was observed to increase in parallel with well-established myocardial markers (P<0.001). Moreover, PGM activity and the lipid, thrombosis, and inflammatory biomarkers in the AMI group were higher than those in the EAP group.Conclusions: PGM activity increased with levels of myocardial, thrombosis, and inflammatory biomarkers in patients with AMI, and might be useful in diagnostic applications during the acute phase in patients with AMI. (Circ J 2012; 76: 2197 - 2203)

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Association of plasma level of malondialdehyde-modified low-density lipoprotein with coronary plaque morphology in patients with coronary spastic angina: Implication of acute coronary events

Cited by 12 publications

References 19 publications

Protective Effects of Mangifera indica L. Extract Against Lipofundininduced Oxidative Stress in Rats

Protective Effects of Mangifera indica L. Extract Against Lipofundininduced Oxidative Stress in Rats

Lipid peroxidation end products in patients with acute coronary syndrome

Phosphoglucomutase Activity as a Novel Biomarker in Patients With Acute Myocardial Infarction

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