Association of plasma aldosterone with the metabolic syndrome in two German populations

Abstract

Objective: The aim of this study was to analyze the potential association of the plasma aldosterone concentration (PAC) with the metabolic syndrome (MetS) and its components in two German population-based studies. Methods: We selected 2830 and 2901 participants (31-80 years) from the follow-ups of the Study of Health in Pomerania (SHIP)-1 and the Cooperative Health Research in the Region of Augsburg (KORA) F4 respectively. MetS was defined as the presence of at least three out of the following five criteria: waist circumference R94 cm (men (m)) and R80 cm (women (w)); high-density lipoprotein (HDL) cholesterol !1.0 mmol/l (m) and !1.3 mmol/l (w); blood pressure R130/85 mmHg or antihypertensive treatment; non-fasting glucose (SHIP-1) R8 mmol/l, fasting glucose (KORA F4) R5.55 mmol/l or antidiabetic treatment; non-fasting triglycerides (SHIP-1) R2.3 mmol/l, fasting triglycerides (KORA F4) R1.7 mmol/l, or lipid-lowering treatment. We calculated logistic regression models by comparing the highest study-and sex-specific PAC quintiles versus all lower quintiles. Results: MetS was common with 48.1% (m) and 34.8% (w) in SHIP-1 and 42.7% (m) and 27.5% (w) in KORA F4. Our logistic regression models revealed associations of PAC with MetS, elevated triglycerides, and decreased HDL cholesterol in SHIP-1 and KORA F4. Conclusions: Our findings add to the increasing evidence supporting a relation between aldosterone and MetS and suggest that aldosterone may be involved in the pathophysiology of MetS and lipid metabolism disorders.

Effects of short-term testosterone administration on variables of the metabolic syndrome, in particular aldosterone

“…The novel aspect is the effect of restoring testosterone to normal on serum aldosterone and its potential effects on hypertension and insulin sensitivity [38,39] . Upon administration of testosterone to the treatment group, serum aldosterone decreased significantly, whereas no effect on waist circumference was noted over this period of time.…”

“…Testosterone has been shown to improve HOMA [55,56] , and it is of interest whether the potential role of lowering aldosterone contributed also to the favorable effects on HOMA and on serum insulin with the potential of better glycemic control [35,38] .…”

Aldosterone and the Mineralocorticoid Receptor: Risk Factors for Cardiometabolic Disorders

“…Population studies performed in Germany [46] and in the USA in Mississippi [47] and Minnesota [48•] demonstrated a positive association between aldosterone levels and the metabolic syndrome. In the Minnesota population, aldosterone also predicted hypertension, central obesity, chronic renal disease, increased triglyceride levels, atrial fibrillation, and concentric left ventricular hypertrophy [48•].…”

The age-specific peculiarities of hormonal and metabolic imbalance in the young and adult men with obesity

“…В ряде клинических исследований зафиксиро-вано повышение уровня альдостерона у больных с ожирением, особенно у пациентов с висцеральным ожирением [10][11][12][13]. При хроническом ожирении повышенная продукция альдостерона сопровожда-ется водно-электролитным дисбалансом.…”