Association of physical activity with insulin resistance, subclinical inflammation, coagulation, and fibrinolytic biomarkers among population at high risk for type 2 diabetes

Stefanov, Tsvetan; Temelkova‐Kurktschiev, Theodora; Koehler, Carsta; Henkel, Elena; Schäper, Frank; Hanefeld, Markolf

doi:10.2478/v10153-011-0086-6

Cited by 11 publications

(7 citation statements)

References 24 publications

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“…In the study of Stefano et al, it was observed that a significant inverse relationship between physical activity levels and insulin resistance exists, in line with previous reports, emphasizing the beneficial effects of exercise on insulin sensitivity in different populations (30). It has been shown that physical activity increases the insulin sensitivity through changes in body fat mass as well as through mechanisms independent of fat mass loss, such as: Increasing the transfer of GLUT4 and the subsequent use of glucose in skeletal muscle, improving the capacity of skeletal muscles for fat oxidation, increasing fat transfer of muscle cells, and reducing the amount of fat metabolites (30).…”

Section: Discussionsupporting

confidence: 77%

“…It has been shown that physical activity increases the insulin sensitivity through changes in body fat mass as well as through mechanisms independent of fat mass loss, such as: Increasing the transfer of GLUT4 and the subsequent use of glucose in skeletal muscle, improving the capacity of skeletal muscles for fat oxidation, increasing fat transfer of muscle cells, and reducing the amount of fat metabolites (30).…”

Section: Discussionmentioning

confidence: 99%

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Effect of Resistance Training with Two Different Volumes on Serum Myonectin Levels in Rats Fed with Sucrose Solution

Adigozalpour

Safarzade

2017

Ann. Appl. Sport Sci

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Background. Moyenctin, is a new identified myokine and belongs to the CTRPs family which plays role in lipid and glucose metabolism. There is limited information available regarding the effects of exercise training on serum myonectin levels. Objectives. he aim of this study was to investigate the effects of sucrose solution intake and resistance training (RT) with two different volumes on serum myonectin levels and HOMA-IR in rats. Methods. Forty-eight male Wistar rats (10-12 weeks old) were randomly divided into six groups; Control (C), Low volume RT (L), High Volume RT (H), Sucrose Control (SC), Sucrose Low volume RT (SL) and Sucrose High volume RT (SH). The RT groups were subjected to a resistance training program with the use of a ladder (3 days/week, for 8 weeks). Body weight and serum levels of myonectin, insulin, glucose, and HOMA-IR were measured. Results. The results two way ANOVA showed that interaction between RT and sucrose solution significantly increased serum levels of insulin (P=0.007) and HOMAL-IR (P=0.002). Consumption of sucrose solution, significantly reduced serum myonectin (P=0.0001) and increased serum glucose, insulin and HOMA-IR (P=0.0001). Also RT significantly reduced serum myonectin, insulin and HOMA-IR (P=0.0001). No correlation was found between serum myonectin and insulin resistance in groups fed with normal foods (P=0.456), but in the groups fed with sucrose solution there was positive and significant correlation (P=0.0001). Conclusion. This data indicated that resistance training regardless of volume of training can reduce serum myonectin levels as well as insulin resistance in rats fed with sucrose solution or normal diet groups.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Effect of Resistance Training with Two Different Volumes on Serum Myonectin Levels in Rats Fed with Sucrose Solution

Adigozalpour

Safarzade

2017

Ann. Appl. Sport Sci

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“…Sedentary lifestyle is a pathogenic factor of obesity development and obesity-related cardiometabolic complications (8)(9)(10)(11)(12)(13)(14)(15). Increased physical activity and exercise training are well-established strategies for the treatment and prevention of obesity and its related diseases (16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Effects of Supervised vs Non-Supervised Combined Aerobic and Resistance Exercise Programme on Cardiometabolic Risk Factors

Stefanov

Vekova²,

Bonova³

et al. 2013

Cent Eur J Public Health

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SUMMARYObjective: We examined the effect of a 6-month combined aerobic and resistance training programme on cardiometabolic risk factors in nondiabetic subjects and compared its effectiveness when executed under strict professional supervision or without direct supervision.Methods: Eighty-five sedentary, non-diabetic subjects (27 men and 58 women), mean age 47.5±0.6 years, mean body mass index (BMI, 33.8±0.6 kg/m 2 ) participated in a combined exercise programme assigned to supervised (S, n=31), non-supervised (NS, n=24) or control group (C, n=30). Cardiometabolic risk parameters were assessed at baseline and after the 6-month training.Results: In both the S and NS group there was a significant decrease in BMI (−1.6±0.3, p<0.001 and −1.0±0.3 kg/m 2 , p=0.004), waist circumference (−10.1±1.1 cm, p<0.001 and −7.8±0.8 cm, p<0.001), fat mass (−1.8±0.4%, p<0.001 and −2.1±0.6%, p=0.003), and a significant increase in fat-free mass (+1.7±0.4%, p<0.001 and +2.0±0.7%, p=0.008), and aerobic capacity (+6.9±1.1, p<0.001 and +6.9±0.8 ml/kg per min, p=0.008). Fasting glucose did not change in S and NS, but increased in C (p=0.048). In the S group a significant decrease in fasting insulin (p<0.001), homeostasis model assessment of insulin resistance (p<0.001), highly sensitive C-reactive protein (p=0.004), leucocytes count (p=0.04), systolic high (p<0.001) and diastolic (p=0.009) blood pressure was found. Comparable significant decreases in total and low-density lipoprotein cholesterol were observed in all study groups.Conclusions: A 6-month combined exercise programme led to substantial improvement of various cardiometabolic risk factors. This programme was effective even when executed without direct supervision, although the effects were more pronounced in the supervised group. Our findings suggest that non-supervised exercise programmes may be a valuable, cost-effective tool to translate the current physical activity guidelines in a real-life setting.

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“…In Stefanov et al (2012) study, a significant inverse relationship was observed between physical activity and insulin resistance level which is in line with previous reports that emphasizes on beneficial effects of physical activity on insulin sensitivity in different populations (39). It has been shown that physical activity through changes in body fat mass and also mechanisms independent on fat mass, such as increased GLUT4 transport and consequently glucose uptake in skeletal muscle, improves the capacity of skeletal muscles for fat oxidation, increase muscle cells' fat transfer and reduces the amount of fat metabolites (39). In this regard, Jorge et al (2011) also observed no change in HOMA-IR index after 12 weeks of combined aerobic and resistance training (34).…”

Section: Discussionmentioning

confidence: 99%

Single and Concurrent Effects of Endurance and Resistance Training on Plasma Visfatin, Insulin, Glucose and Insulin Resistance of Non-Athlete Men with Obesity

Tayebi

Saeidi

Khosravi

2016

Ann. Appl. Sport Sci

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The purpose of the present study was to investigate the effect of endurance (ET), resistance (RT) and concurrent training (CT) on plasma levels of visfatin, insulin, glucose and insulin resistance of non-athlete men with Obesity. It was a semi-experimental study. Thirty six men [age: 21.48 (0.25), and BF%: 27.39 (0.52)], voluntarily participated in this study after public announcement in university. Main inclusion and exclusion criteria was healthy (no physical illness and inability), obesity [based on WHO's definition body fat percentage (BF%) of over 25] and non-athlete (without regular training during week). They were randomly divided into three groups (n=12) for ET, RT and CT. For 8 weeks (3sessions/week), the candidates participated in ET (25-40 min at 65-85% of maximum heart rate), RT (5exercises, 6sets, intensity: 50-80% of one repetition maximum, volumes: 5, 8 and 12repetitions) and CT (one or a half-term ET and then RT with 3 sets). Blood samples were taken 48 h before the first training session and 48 h after the last training session. The BF% in ET was significantly less than that in RT (p0.01), and in CT, it was less than that for both ET and RT (p0.01). Plasma visfatin only, in CT was significantly less than that in RT (p0.01). Plasma insulin levels in CT were significantly higher than that in ET and RT (p0.01). Plasma glucose levels in CT were less than that in ET and RT, significantly (p0.01). Insulin resistance only in CT was less than that in ET significantly (p0.01). In general, the present study showed that maybe, CT have more effect on the body composition, glucose metabolism and insulin resistance adjustment, which can be effective in preventing obesity and adjusting adipocytokines such as visfatin.

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Association of physical activity with insulin resistance, subclinical inflammation, coagulation, and fibrinolytic biomarkers among population at high risk for type 2 diabetes

Cited by 11 publications

References 24 publications

Effect of Resistance Training with Two Different Volumes on Serum Myonectin Levels in Rats Fed with Sucrose Solution

Effect of Resistance Training with Two Different Volumes on Serum Myonectin Levels in Rats Fed with Sucrose Solution

Effects of Supervised vs Non-Supervised Combined Aerobic and Resistance Exercise Programme on Cardiometabolic Risk Factors

Single and Concurrent Effects of Endurance and Resistance Training on Plasma Visfatin, Insulin, Glucose and Insulin Resistance of Non-Athlete Men with Obesity

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