Association of persisting IgA response with yersinia triggered reactive arthritis: a study on 104 patients.

Toivanen, Auli; Lahesmaa‐Rantala, Riitta; Vuento, Risto; Granfors, Kaisa

doi:10.1136/ard.46.12.898

Cited by 59 publications

(20 citation statements)

References 12 publications

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“…The present findings provide evidence against the latter possibility and rather suggest that the microbes stay in the depths of intestinal mucosa, occasionally being secreted in the feces. This is also the clinical experience from patients with Yersinia infection, with or without ReA (20,21). The occult persistence of Yersinia is also exemplified by several cases of Yersinia septicemia following transfusion of stored blood obtained from healthy individuals (22).…”

Section: Discussionmentioning

confidence: 82%

Antibiotic prophylaxis and treatment of reactive arthritis. Lessons from an animal model

Zhang¹,

Gripenberg-Lerche²,

Söderström³

et al. 1996

Arthritis & Rheumatism

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Objective. To study the effect of antibiotic prophylaxis and treatment of reactive arthritis (ReA), using an experimental model.Methods. Yersinia enterocolitica 0:8, when injected intravenously into Lewis rats, causes a sterile arthritis closely resembling human ReA in 70% of the animals. Arthritis develops in 1-2 weeks; in some of the animals it remains chronic, and exacerbations occur. This model was applied to study the effect of a 7-day treatment with ciprofloxacin, using 2 different dosages (20 or 100 mg/kg/day) and 4 different schedules for initiation of treatment. The effects were evaluated by determining the daily arthritis score, the number of rats developing arthritis, and fecal excretion of Yersiniu. In addition, weight gain was monitored. At autopsy (35 or 60 days after inoculation with bacteria), samples were obtained for determination of Yersiniu-specific antibodies in the serum. At the same time, samples were collected from mesenteric lymph nodes, lung, spleen, and liver for bacterial cultures, and from the ankle joints for histologic evaluation. In a separate experiment, ciprofloxacin concentrations in samples from serum and mesenteric lymph nodes were analyzed by high performance liquid chromatography.Results. A 7-day course with 100 mg/kg/day of ciprofloxacin, started on day 3 after bacterial inocula-

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Section: Discussionmentioning

confidence: 82%

Antibiotic prophylaxis and treatment of reactive arthritis. Lessons from an animal model

Zhang¹,

Gripenberg-Lerche²,

Söderström³

et al. 1996

Arthritis & Rheumatism

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“…The workers in occupations which involved close contact with swine had more frequently elevated Ig G class ant ibodies against these serotypes. The Ig G class is the type which stays elevated for the greatest length of time after yersinosis with no postinfectious arthritis (26 for the nonarthritis cases and 33 (85%) for the arthritis subjects (27). However, it is not known how long Ig G antibodies persist after entirely asymptomatic enteric infection.…”

Section: Resultsmentioning

confidence: 99%

Antibodies against Yersinia among farmers and slaughterhouse workers.

Seuri¹,

Granfors²

1992

Scand J Work Environ Health

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SEURI M, GRANFORS K. Ant ibod ies against Yersinia among farmer s and slaughterhouse workers . Scand J Work Environ Health 1992;18:128-132. Antibodies to immuno globulins (Ig) M, G, and A against Yersinia enterocolitica serotypes 0:3 , 0:5, 0:8, and 0 :9 and Yersinia pseudotuberculosis serotype s I and III were analyzed by enzyme immunoassay of the serum samples of 161 slaughterhouse workers, 147 pig farmer s, and 114 grain or berry farmer s. The crude risk ratio s for elevated serum antibody concentrations were calculated with the use of the grain and berr y farmers as the reference population. The risk for an elevated Yenterocolitica 0 :3 Ig G concentration was 3.0 (95070 confidence interval (95070 CI) 1.3-7.1) for the pig farmers and 1.8 (95070 CI 0.7-4.4) for the slaughterhouse workers and the respective risks for elevated Yenterocolitica 0:9 Ig G were 2.4 (95070 CI 1.1-5.5) and 1.7 (95070 CI 0.7-4.0) . Since these two serotypes are commonly associated with swine, the increased number of subjects with elevated antibody levels could be causally related to occupational contact with this animal.

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“…We interpret the increased antibody frequencies in HLA-B27+ individuals as 1) a sign of increased susceptibility to infections caused by yersiniae, salmonellae, and K pneurnoniae, or 2) an increased immune response toward these microbes. Whether the antibodies observed represent a recent or an old infection cannot be determined, since even IgM-class antibodies against Yersinia may persist for years (7). The two possibilities are not mutually exclusive, and both could contribute to the pathogenesis of spondylarthropathies.…”

Section: Bacterial Antibodies In Hla-b27+ Healthy Individualsmentioning

confidence: 99%

“…Studies in rabbits demonstrated that the volume of the injection was the major factor in muscle damage (6,7). Damage caused by all aqueous preparations was ameliorated to various degrees by different oil vehicles.…”

mentioning

confidence: 99%

Bacterial antibodies in HLA‐B27+ healthy individuals

Toivanen

Koskimies

Granfors

et al. 1993

Arthritis & Rheumatism

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1633various vehicles or given vehicle alone, all preparations except physiologic saline caused changes in the tissues at the injection site: necrotic muscle tissue, foreign-body reaction, and eventual scar tissue (5). Studies in rabbits demonstrated that the volume of the injection was the major factor in muscle damage (6,7). Damage caused by all aqueous preparations was ameliorated to various degrees by different oil vehicles.From the results of these animal studies, more frequent problems than are seen in practice might be expected. The 2 patients described herein had received large cumulative volumes of ATG in a small area of muscle. Varying the site of injection in large muscle groups results in a low risk of developing oily abscess. Although magnetic resonance imaging would be a sensitive tool for demonstrating an oily abscess, it is much more expensive than a good ultrasound study. Moreover, in the absence of clinical indications, screening seems unnecessary. James M. Sowa, MD, FACR St. Joseph Hospital Towson, MD 1. 2.3. 4. 5. 6.7. Bacterial antibodies in HLA-B27+ healthy individualsThe mechanisms that cause susceptibility to ankylosing spondylitis and reactive arthritis in HLA-B27 + individuals remain unknown. Several theories have been proposed, including molecular mimicry and involvement of genes closely linked to the HLA-B locus (1). However, none of these, nor the identification of self peptides bound to purified HLA-B27 molecules, has shed any decisive light on the question (2). If HLA-B27 functions as an immune response gene in the pathogenesis of spondylatihropathies, the effect should be apparent in the immune response. Thus far, no clear evidence for this has been found (3). The most obvious targets for such an immune response are the microbes identified as etiologic agents for reactive arthritis. These microbes can be readily investigated by available methods. Therefore, we studied HLA-B27+ healthy blood donors for the occurrence of antibodies against various serotypes of Yersinia enterocolitica and Yersinia pseudotuberculosis as well as against Salmonella and Campylobacter jejuni, all known to cause reactive arthritis (4). Klebsiella pneumoniae was also included, due to its potential association in the pathogenesis of ankylosing spondylitis (5). Proteus mirabilis and Escherichia coli, which have no known connection to HLA-BU-associated diseases, were used as control antigens.The occurrence of the serum antibodies was studied in 927 healthy blood donors typed for the HLA class I antigens Al, 2, 3, 9, 10, 11, 19, and 28; B5, 7, 8, 12, 13, 14, 15, 16, 17, 18, 21, 22, 27, 35, 37, 40, 41, and 47; and Cwl-Cw8. Enzyme immunoassay for IgM-, IgG-, and IgAclass antibodies specific for the various microbes was carried out as described earlier (6). Bacterial strains used for antigen preparation, and the sources from which they were obtained, were as follows: Y enterocolitica 0:3 (strain MY 0; S. Winblad , and E coli (strain 8330; a clinical isolate, Turku). For yersiniae, K pneumoniae, P mirabilis, and E...

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Association of persisting IgA response with yersinia triggered reactive arthritis: a study on 104 patients.

Cited by 59 publications

References 12 publications

Antibiotic prophylaxis and treatment of reactive arthritis. Lessons from an animal model

Antibiotic prophylaxis and treatment of reactive arthritis. Lessons from an animal model

Antibodies against Yersinia among farmers and slaughterhouse workers.

Bacterial antibodies in HLA‐B27+ healthy individuals

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