Association of peroxisome proliferator-activated receptor-gamma gene polymorphisms with the development of asthma

Abstract

Association analysis using logistic regression analysis showed that +82466C>T and haplotypes 1(CC) and 2(CT) were associated with the development of asthma (p=0.01-0.04). The frequency of PPARG-ht2 was significantly lower in the patients with asthma compared to the normal controls in codominant and dominant models (p=0.01, p(corr)=0.03 and p=0.02, p(corr)=0.03, respectively). Conversely, the frequency of PPARG-ht1 was significantly higher in the patients with asthma compared to the normal controls in the codominant model [p=0.04, OR: 1.27 (1.01-1.6)]. In addition, the rare allele frequency of +82466C>T was significantly lower in patients with asthma in comparison to normal controls in the codominant model (OR: 0.78, p=0.04). Thus, polymorphism of the PPARG gene may be linked to an increased risk of asthma development.

Small RNA profiling reveals deregulated phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/Akt pathway in bronchial smooth muscle cells from asthmatic patients

“…Several genes from this list were previously associated with asthma. Among them is the PPARG gene encoding the peroxisome proliferator-activated receptor, which is known to be involved in airway inflammatory and remodeling responses 43 and considered to be a novel therapeutic target for asthma. [44][45][46][47] Another miRNA target expressed in airway smooth muscle cells encodes for the adenosine A2b receptor (ADORA2B), the antagonists of which are thought to be promising potent anti-inflammatory agents rather than bronchodilators for the treatment of asthma 48 because adenosine is a powerful bronchoconstrictor of asthmatic airways and acts not only as an inflammatory mediator in asthmatic patients but also participates in airway wall remodeling.…”

Haploinsufficiency for Stard7 Is Associated with Enhanced Allergic Responses in Lung and Skin

“…Both PPARα and -γ antagonize several transcription factors involved in the effector phase of allergic inflammation, including nuclear factor-κB (NF-κB) and activator protein-1 (AP-1)(24–27). Humans with polymorphisms in PPARγ are at an increased risk for developing asthma(28, 29). Consistent with these findings, mice deficient in PPARα presented with increased eosinophilia, IgE production and AHR following allergen challenge(30), while mice treated with PPARγ agonists were protected against disease(30–34).…”

Association of peroxisome proliferator-activated receptor gamma polymorphisms with inflammatory bowel disease in a Hungarian cohort

“…20,24 Polymorphisms of PPARc have been examined in diabetes and obesity, and also in disorders with autoimmune origins such as psoriasis, psoriatic arthritis, asthma, and IBD. [50][51][52] However, only a few studies have examined the association of PPARc polymorphisms with in IBD so far. Sugawara et al 26 identified PPARc as a susceptibility gene for CD.…”