Association of peroxisome proliferator-activated receptor-delta polymorphisms with sugar metabolism indices and tumor necrosis factor alpha level

Abstract

ABSTRACT. This study aims to investigate the association of peroxisome proliferator-activated receptor (PPAR) delta -87T/C polymorphism with several sugar metabolism indices and tumor necrosis factor α (TNF α) level. The body mass index (BMI), waist size, and levels of fasting plasma glucose, serum lipid, fasting insulin, TNFα, and PPAR delta -87T/C of 286 patients with type 2 diabetes mellitus (T 2 DM) and 158 subjects with normal fasting glucose (NFG) were measured in a Dalian population. The distribution of genotypic frequencies between T 2 DM and NFG were not significantly different (χ 2 = 0.012, P = 0.994). BMI, fasting blood glucose (FBG), homeostasis model assessment-estimated insulin resistance (HOMA-IR), triglyceride, and TNFα levels were significantly different among different T 2 DM genotypes. HOMA-IR and FBG were significantly different among different NFG genotypes. The PPAR delta -87T/C polymorphism is known to be closely related with glucose levels and lipid metabolism. A close relationship was also found between

An Exploratory Critical Review on TNF-α as a Potential Inflammatory Biomarker Responsive to Dietary Intervention with Bioactive Foods and Derived Products

“…We additionally reviewed a number of studies reporting the levels of TNF-α across the different genotypes for other variants associated with different genes related with obesity and metabolic disorders [ 137 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 ] ( Table S8 ). We also found a very high genotype intra-subgroup variability (CV% >40% in most cases), highly variable levels (0.11–90 pg/mL) in the homozygous reference subgroups, and small and mostly (NS) differences across the genotypes except for some specific SNPs.…”

“…We also found a very high genotype intra-subgroup variability (CV% >40% in most cases), highly variable levels (0.11–90 pg/mL) in the homozygous reference subgroups, and small and mostly (NS) differences across the genotypes except for some specific SNPs. Like so, the TNF-α levels were (S) reduced in Chinese adults with T2D with the rare variant −87 T > C of PPARD ( p < 0.05, −1.7 and −3.1 pg/mL) [ 146 ], in malnourished elderly people with the rare variant of rs769214 of CAT ( p < 0.001, −3.2 and −3.9 pg/mL) [ 153 ], in patients with heart failure and with the rare genotype for rs1800471 of TGFB ( p = 0.042, −7.0 pg/mL) [ 154 ], and in healthy individuals with the rare rs2234632 variant of the gene ZIP2 ( p = 0.011, −6.1 pg/mL) [ 155 ]. On the other hand, a few other SNPs were found to have more elevated levels of TNF-α in individuals with the rare variant, e.g.…”