Association of periodontitis with metabolic syndrome: A case-control study

Abstract

A BSTRACT Aim: This study was undertaken to assess the association between periodontitis and metabolic syndrome. Materials and Methods: A case-control study was designed among 100 cases as patients with metabolic syndrome aged 35–74 years, and age- and sex-matched 100 controls as apparently healthy relatives or friends accompanying the cases visiting the diabetic outpatient department at Victoria Hospital, Bengaluru, Karnataka, India, using convenience sampling method. Information related to diabetes, hypertension, and oral hygiene practices was collected. Periodontal health status was measured using community periodontal index. Metabolic syndrome was diagnosed based on the criteria of National Cholesterol Education Program Adult Treatment Panel III. Chi-square test and logistic regression were used for analysis. Results: Significantly more number of cases had shallow pockets 4–5 mm, deep pockets ≥ 6 mm, and also more number of loss of attachment code 1, code 2, code 3, and code 4 compared to controls. Bivariate analysis showed significant association between metabolic syndrome and body mass index, smoking, and tobacco chewing. The association between periodontitis and metabolic syndrome was significant with increased risk of developing metabolic syndrome among the subjects with community periodontal index code 3 and code 4 (odds ratio [OR] = 17) and among the subjects having loss of attachment code 1, code 2, code 3, and code 4 (OR = 12). Association remained significant even after adjustment with other variables (adjusted OR = 6). Conclusion: This study showed significant association between periodontitis and metabolic syndrome. Further prospective and randomized control trials are recommended to assess causal association between these two diseases.

Aplicação De Réplicas Tridimensionais Em Transplantes Dentários Autógenos Convencionais: Revisão De Literatura

“…É possível que a associação entre periodontite e SM (BANDIWADEKAR et al, 2020) possa ser explicada por um estresse oxidativo sistêmico e uma resposta inflamatória exacerbada e pelo compartilhamento de um perfil de fatores de risco em comum. No entanto, essa relação ainda não foi elucidada (CAMPOS, 2019).…”

Periodontitis severity relationship with metabolic syndrome: A systematic review with meta‐analysis

“…A descriptive summary of the included studies is in the Supplemental material-S5. Of the 14 studies published between 2007 and 2020, 11 were cross-sectional (Benguigui et al, 2010;Chen et al, 2011;D'Aiuto et al, 2008;de Borges et al, 2007;Fukui et al, 2012;Gomes-Filho et al, 2016;LaMonte et al, 2014;Li et al, 2020;Minagawa et al, 2015;Nesbitt et al, 2010;Pham, 2018) and 3 case-controls (Bandiwadekar et al, 2020;Campos et al, 2020;Gomes-Filho et al, 2021). The sample consisted of 24,567 participants, a median of 365 individuals, with a mean age of 57.6 years.…”

“Dental Cluster” Versus “Metabolic Cluster”: Analyzing the Associations of Planned and Delivered Dental Procedures with Metabolic Syndrome, Utilizing Data from the Dental, Oral, Medical Epidemiological (DOME) Cross-Sectional Record-Based Nationwide Study

“…We have also analyzed the associations between MetS and the diagnosis of "SOS teeth", which are the first priority teeth for treatment due to advanced caries reaching the pulp chamber or the presence of root fragments [12]. In other studies, instead of using pathologies as dental outcomes, the dental-MetS associations were analyzed using dental/periodontal indices as outcomes, including the Decayed, Missing, and Filled teeth (DMFT) index [6,7,13,14], the Community Periodontal Index (CPI) [15,16], clinical attachment loss (CAL) [16,17], plaque index (PI), gingival index (GI), pocket depth (PD) [18], and tooth mobility [19]. Previously, we explored the associations of hypertension diagnosis with dental treatment needs and actual dental treatments [20].…”