Association of Periodic Limb Movements With Medication Classes

Hoxha, Ortenc; Jairam, Trevor; Kendzerska, Tetyana; Rajendram, Phavalan; Zhou, Ryan; Ravindran, Prashanthan; Osman, Sinan; Banayoty, Monica; Qian, YuChen; Murray, Brian J.; Boulos, Mark I.

doi:10.1212/wnl.0000000000200012

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Those results were expected as SSNRIs are known to delay REM sleep latency and increase N1 sleep duration in subjects without sleep disorders 50 , 51 . Our results also showed that IH patients using antidepressants had higher micro-arousal and PLMS indices than both controls and other IH participants, which can indicate a more fragmented sleep, which is concordant with observations that SSNRIs can impair sleep continuity and increase PLMS 50 , 52 . Since IH participants using antidepressants were mainly women, those results are in line with the findings of Plante 8 , where women with IH had worse sleep efficiency compared to healthy women.…”

Section: Discussionsupporting

confidence: 91%

Sleep architecture in idiopathic hypersomnia: the influence of age, sex, and body mass index

Deshaies-Rugama,

Mombelli,

Blais

et al. 2024

Sci Rep

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This study aimed to progress the understanding of idiopathic hypersomnia (IH) by assessing the moderating influence of individual characteristics, such as age, sex, and body mass index (BMI) on sleep architecture. In this retrospective study, 76 IH participants (38.1 ± 11.3 years; 40 women) underwent a clinical interview, an in-laboratory polysomnography with a maximal 9-h time in bed and a multiple sleep latency test (MSLT). They were compared to 106 healthy controls (38.1 ± 14.1 years; 60 women). Multiple regressions were used to assess moderating influence of age, sex, and BMI on sleep variables. We used correlations to assess whether sleep variables were associated with Epworth Sleepiness Scale scores and mean sleep onset latency on the MSLT in IH participants. Compared to controls, IH participants had shorter sleep latency (p = 0.002), longer total sleep time (p < 0.001), more time spent in N2 sleep (p = 0.008), and showed trends for a higher sleep efficiency (p = 0.023) and more time spent in rapid eye movement (REM) sleep (p = 0.022). No significant moderating influence of age, sex, or BMI was found. More severe self-reported sleepiness in IH patients was correlated with shorter REM sleep latency and less N1 sleep in terms of proportion and duration (ps < 0.01). This study shows that, when compared to healthy controls, patients with IH had no anomalies in their sleep architecture that can explain their excessive daytime sleepiness. Moreover, there is no moderating influence of age, sex, and BMI, suggesting that the absence of major group differences is relatively robust.

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