Association of pericardial adipose tissue volume with presence and severity of coronary atherosclerosis

Abstract

Association of pericardial adipose tissue volume with presence and severity of coronary atherosclerosis Abstract Purpose: is study was to investigate whether high pericardial adipose tissue (PAT) volume is related to the presence and severity of coronary artery disease (CAD).Methods: Consecutive patients (310 patients) who underwent both dual-source 64-slice CT and percutaneous coronary angiography were recruited into this study. Waist circumference (WC), body mass index (BMI), blood biochemical variables, coronary artery calcium (CAC) score and Gensini score were measured. Pericardial adipose tissue (PAT) volume was determined by dual-source CT.Results: PAT volume was positively correlated with BMI, WC, gender (male), hypertension, diabetes, age, total cholesterol and low-density lipoprotein-cholesterol. PAT volume in CAD patients was signi cantly higher than that in patients without CAD (238.36 ± 81.21 cm 3 vs. 200.13±72.34 cm 3 ). PAT volumes in patients with multi-vessel lesions were signi cantly higher than those with one-vessel lesions (P<0.001). A signi cant correlation between PAT volume and CAC score (r=0.305, P<0.001) was found. PAT volume was an independent factor a ecting Gensini score. Conclusion:PAT volume was signi cantly correlated with traditional cardiovascular risk factors, the severity of coronary atherosclerosis and the number of stenotic coronary vessels. us, PAT volume may be a reliable marker to evaluate the presence and severity of CAD.

Associations of C1q/TNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans

“…The pathological increase in EAT and the concomitance of other metabolic and hemodynamic abnormalities turn it into an adverse lipotoxic, prothrombotic, and proinflammatory organ [ 13 – 15 ]. Our previous study showed that pericardial adipose tissue volume was significantly correlated with traditional cardiovascular risk factors, the severity of CA, and the number of stenotic coronary vessels [ 16 ]. EAT-derived inflammatory cytokines are also significantly related to the plaque vulnerability in CAD.…”

Association of pericardial fat volume with coronary atherosclerotic disease assessed by CT angiography

“…8 Furthermore, recent data have shown that PFV assessed by CT angiography is significantly associated with severe coronary stenosis, plaque burden even in asymptomatic individuals, high-risk plaque features and an increased risk of future cardiac events. [9][10][11] The aim of this study was to investigate the association of PFV with CAD, cardiac risk factors and calcium scoring index in patients with an intermediate pre-test probability of ischaemic heart disease assessed by coronary CT angiography.…”

Development of artificial intelligence in epicardial and pericoronary adipose tissue imaging: a systematic review

“…Studies have shown that EAT is associated with cardiovascular diseases (CVDs) such as arrhythmia, coronary artery disease, and heart failure (Topuz and Dogan 2017 ; Abe et al 2018 ; Mancio et al 2018 ). In addition, there is evidence that the PCAT around the coronary artery is the source of adipocytokines, which influences the development of coronary artery disease (Wang et al 2013 ; Opincariu et al 2020 ).…”