Association of Paternal Age With Perinatal Outcomes Between 2007 and 2016 in the United States: Population-based Cohort Study

Khandwala, Yash S.; Baker, Victoria L.; Shaw, Gary M.; Stevenson, D.K.; Lu, Yulan; Eisenberg, M.

doi:10.1097/01.aoa.0000557657.79785.e6

Cited by 12 publications

(18 citation statements)

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“…From 2004 to 2016, there was a decline in morbidity due to PE in China, while during 1980-2016, a yearly increase in morbidity was observed in the US (Fig. 1 and Table I) (10)(11)(12)(13)(14)(15)(16)(17)(18). These observations were in discordance with the previously determined higher incidence of PE in developing countries and led us to explore the reasons for this difference.…”

Section: Introductionmentioning

confidence: 70%

Differences in epidemiology of patients with preeclampsia between China and the US (Review)

et al. 2021

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Section: Introductionmentioning

confidence: 70%

Differences in epidemiology of patients with preeclampsia between China and the US (Review)

et al. 2021

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“…1,5 A recent population-based retrospective study of over 40 million births in the USA observed that a father's age ≥45 years increased the odds of gestational diabetes in the mother and preterm birth and neonatal seizures. 5 Earlier studies suggested advanced paternal age was associated with increased rates of pregnancy loss and poor obstetric outcomes. [6][7][8] A systematic review of adverse shortand long-term child outcomes showed an association between advancing paternal age and several neuropsychiatric disorders, as well as stillbirth, orofacial clefts and trisomy 21.…”

Section: Introductionmentioning

confidence: 99%

“…Increasing paternal age has been associated with an increase in the risk of adverse pregnancy outcome and may impact child health 1,5 . A recent population‐based retrospective study of over 40 million births in the USA observed that a father’s age ≥45 years increased the odds of gestational diabetes in the mother and preterm birth and neonatal seizures 5 . Earlier studies suggested advanced paternal age was associated with increased rates of pregnancy loss and poor obstetric outcomes 6–8 .…”

Section: Introductionmentioning

confidence: 99%

Paternal age over 50 years decreases assisted reproductive technology (ART) success: A single UK center retrospective analysis

Morris

Mavrelos

Odia

et al. 2021

Acta Obstet Gynecol Scand

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Introduction: To study whether paternal age exerts an effect, independent of maternal age, on the outcomes of fresh in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) cycles. Semen quality deteriorates with increasing paternal age; however, there is conflicting evidence for any impact paternal age may have on the outcome of IVF/ICSI. Several retrospective and prospective cohort studies have shown that paternal age increases the miscarriage rate and reduces the live birth rate. Some studies have shown no effect of paternal age on live birth rate or miscarriage rate. Studies involving donor oocytes have tended to show no independent effect of paternal age on assisted reproductive technology (ART) outcomes. The age at which paternal age may exert a significant deleterious effect on outcome is not known and there is no limit to paternal age in IVF/ICSI treatment. Material and methods:A single-center retrospective cohort study was carried out at the Centre for Reproductive and Genetic Health, London, UK. Included in the analysis were all couples with primary or secondary infertility undergoing IVF/ICSI cycles in which the male partner produced a fresh semen sample and the cycle proceeded to fresh embryo transfer. All cycles of IVF/ICSI that used donor oocytes-donor sperm, frozen sperm, cycles leading to embryo storage and cycles including preimplantation genetic testing (PGT-A/PGT-M)-were excluded from analysis. The primary outcome was live birth rate and secondary outcomes were clinical pregnancy rate and miscarriage rate. Multivariate logistic regression analysis with live birth as a dependent variable and maternal and paternal age class as independent variables was performed. Results: During the study period there were 4833 cycles, involving 4271 men, eligible for analysis; 1974/4833 (40.8%, 95% confiene intervals [CI] 39.5-42.2%) cycles resulted in a live birth. A significantly lower proportion of men over 51 years met World Health Organization semen analysis criteria (56/133, [42.1%, 95% CI 34.1-50.6]) compared with men under 51 years of age (2530/4138 [61.1%, 95% CI 60.0-62.6]) (p = 0.001). Both maternal and paternal age were retained in the multivariate model | 1859 MORRIS et al. | MATERIAL AND ME THODSThis was a retrospective cohort study conducted at the Centre for Reproductive and Genetic Health, London, UK.Data for in vitro fertilization (IVF) cycles carried out in our unit are held on a clinical database (IDEAS, version 6 Mellowood Medical software). We created a database query to retrieve data on all couples that underwent an IVF or intracytoplasmic sperm injection (ICSI) cycle with fresh embryo transfer from 1 December 2009 to 1 August 2018. We excluded cycles that used donor gametes (oocytes/sperm) and those that used frozen or surgically retrieved sperm. Our study did not include donor oocyte cycles to allow analysis of the effect and for all maternal age subgroups the probability of live birth decreased with paternal age over 50 years (odds ratio [OR] 0.674, 95% CI 0.482-0.943) (p = 0...

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“…The medical literature tends to find that advanced paternal age is associated with worse birth outcomes, such as lower birth weight and higher risk of stillbirths (NyboAndersen and Urhoj, 2019, andKhandwala et al 2018). …”

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confidence: 99%

School Starting Age, Maternal Age at Birth, and Child Outcomes

2021

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Any opinions expressed in this paper are those of the author(s) and not those of IZA. Research published in this series may include views on policy, but IZA takes no institutional policy positions. The IZA research network is committed to the IZA Guiding Principles of Research Integrity. The IZA Institute of Labor Economics is an independent economic research institute that conducts research in labor economics and offers evidence-based policy advice on labor market issues. Supported by the Deutsche Post Foundation, IZA runs the world's largest network of economists, whose research aims to provide answers to the global labor market challenges of our time. Our key objective is to build bridges between academic research, policymakers and society. IZA Discussion Papers often represent preliminary work and are circulated to encourage discussion. Citation of such a paper should account for its provisional character. A revised version may be available directly from the author.

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Association of Paternal Age With Perinatal Outcomes Between 2007 and 2016 in the United States: Population-based Cohort Study

Cited by 12 publications

References 0 publications

Differences in epidemiology of patients with preeclampsia between China and the US (Review)

Differences in epidemiology of patients with preeclampsia between China and the US (Review)

Paternal age over 50 years decreases assisted reproductive technology (ART) success: A single UK center retrospective analysis

School Starting Age, Maternal Age at Birth, and Child Outcomes

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