Association of parvovirus B19 infection with acute glomerulonephritis in healthy adults: case report and review of the literature

Mori, Yoshihide; Yamashita, Hiroyuki; Umeda, Yukihisa; Uchiyama-Tanaka, Yoko; Nose, Atsuko; Kishimoto, Noriko; Kijima, Yasuaki; Nagata, Toshiko; Mori, Mikio; Matsubara, Hirofumi; Yoshida, Hayato; Iwasaka, Tsuyoshi

doi:10.5414/cnp57069

Cited by 33 publications

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“…5,9,10 Indeed, increased levels of circulating immune complexes have been seen during acute parvovirus B19 infection. 6,9 It is likely that the protracted symptoms our patient experienced resulted from the formation, circulation, and deposition of immune complexes. The presence of globoside in the kidneys and bowel also raises the possibility of direct infection of these organs.…”

Section: Commentarymentioning

confidence: 99%

“…These symptoms typically appear 1-2 weeks after the initial viral syndrome. 5,6 With supportive care, most recover spontaneously, although chronic kidney disease has been reported. 7,8 Published kidney biopsy findings of parvovirus B19 show endocapillary or mesangial proliferative glomerulonephritis with subendothelial electrondense deposits and granular deposition of C3, IgG, or IgM along the capillary walls and mesangium.…”

Section: Commentarymentioning

confidence: 99%

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Ryder

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Lurie

2006

Journal of Hospital Medicine

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The approach to clinical conundrums by an expert clinician is revealed through presentation of an actual patientThe patient presents with gastrointestinal symptoms following a trip to China. He may have an infection that began in the respiratory system and now is causing some gastrointestinal symptoms, like Legionnella. If he had received antibiotics, the diarrheal illness could be a complication. With his recent travel to China, typical enteric pathogens would have to be considered: enterotoxigenic E. coli, Shigella, Salmonella, Campylobacter, or perhaps Giardia.He was admitted and treated with intravenous fluids and ciprofloxacin for presumed gastroenteritis. He was discharged the next day but returned 2 days later because of continued nausea and vomiting and limited oral intake. He was febrile, to 38.9°C, with chills. The results of an abdominal exam were normal. Stool studies for Salmonella, Shigella, Campylobacter, Yersinia, enterotoxigenic E. coli, Giardia, and Cryptosporidium were negative. No blood parasites were seen. The white-cell count was 3900/ mm 3 with a normal differential count. Hemoglobin level, platelet count, serum electrolytes and creatinine were normal. He was readmitted for intravenous fluids.

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Section: Commentarymentioning

confidence: 99%

Section: Commentarymentioning

confidence: 99%

Don't just do something, stand there!

Ryder

Block

Lurie

2006

Journal of Hospital Medicine

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“…7 Only recently has renal involvement due to parvovirus B19 infection in healthy individuals been described and overall 16 cases with an endocapillary proliferative glomerulonephritis and, usually, a nephrotic syndrome have been described since 1999. [8][9][10][11] A single case of cutaneous vasculitis with proteinuria and a proliferative glomerulonephritis in association with parvovirus B19 infection is reported in the UK literature, but without complete clinical, biochemical, immunological, serological, and immunohistochemical data, to support a diagnosis of post-infectious endocapillary glomerulonephritis. 11 More recently, Quek et al described three patients in United Kingdom who developed nephrotic syndrome following parvovirus B19 infection in patients with sickle-cell disease.…”

Section: -4mentioning

confidence: 99%

Endocapillary glomerulonephritis secondary to human parvovirus B19 presenting with nephrotic syndrome: a report of two cases and a review of the literature

2010

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“…2,3 Renal involvement in patients with HPVB19 infection was not discussed in early reports, but a causal relationship between this infection and acute glomerulonephritis has been suggested in recent, mostly anecdotal, case reports. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] The majority of these reports were described in adults, whereas only a few cases of children were defined who presented with mesangiocapillary proliferative glomerulonephritis, focal segmental glomerulosclerosis (FSGS), or tubulointerstitial nephritis. We present the first pediatric case of acute endocapillary proliferative glomerulonephritis (AEPGN) induced by HPVB19 that did not resolve spontaneously.…”

Section: Introductionmentioning

confidence: 99%

“…1 Other clinical manifestations that can occur with HPVB19 infection include arthritis or arthralgia, transient aplastic crisis, fetal hydrops, and chronic infection with anemia. 2 Most of the HPVB19 infections are usually mild or asymptomatic, and multisystem involvement simulating a connective tissue disorder or malignancy is extremely rare. However, in some cases, infection is associated with serious systemic complications for which treatment is indicated and may be life saving.…”

Section: Introductionmentioning

confidence: 99%

Parvovirus B19-induced multisystemic vasculitis and acute endocapillary proliferative glomerulonephritis in a child

et al. 2010

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A 10-year-old girl was admitted with fever, cough, maculopapular rash, hemoptysis, dark-colored urine, edema, multiple lymphadenopathies, and hepatosplenomegaly. She developed acute glomerulonephritis during the course of these complex clinical features. Laboratory data showed hematuria, proteinuria, and hypocomplementemia. Serological tests showed positive human parvovirus B19 (HPVB19)-specific immunoglobin M (IgM) and HPVB19 DNA was detected in the patient's serum using polymerase chain reaction (PCR). Renal biopsy revealed acute endocapillary proliferative glomerulonephritis (AEPGN) with coarse granular C3 depositions in a "starry sky pattern," which is more peculiar to poststreptococcal glomerulonephritis. Electron microscopy showed subendothelial and small hump-shaped subepithelial electron-dense deposits in glomerular capillary walls. There was no evidence of either any mycobacterial, staphylococcal, or streptococcal infection, and the diagnosis of Goodpasture syndrome and connective tissue disorders was excluded during clinical and laboratory investigations. A diagnosis of HPVB19-induced pleuropneumonitis and glomerulonephritis was made. Through a literature search there was no documented pediatric case of AEPGN induced by HPVB19, and this case represents, to our knowledge, the first time that a direct relationship between parvovirus infection and AEPGN has been demonstrated in a child.

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Association of parvovirus B19 infection with acute glomerulonephritis in healthy adults: case report and review of the literature

Cited by 33 publications

References 0 publications

Don't just do something, stand there!

Don't just do something, stand there!

Endocapillary glomerulonephritis secondary to human parvovirus B19 presenting with nephrotic syndrome: a report of two cases and a review of the literature

Parvovirus B19-induced multisystemic vasculitis and acute endocapillary proliferative glomerulonephritis in a child

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