Association of parental history of type 2 diabetes with age, lifestyle, anthropometric factors, and clinical severity at type 2 diabetes diagnosis: results from the DD2 study

Svensson, Elisabeth; Berencsi, Klára; Sander, Simone; Mor, Anil; Rungby, Jørgen; Nielsen, Jens Steen; Friborg, Søren; Brandslund, Ivan; Christiansen, Jens Sandahl; Vaag, Allan; Beck‐Nielsen, Henning; Sørensen, Henrik Toft; Thomsen, Reimar Wernich

doi:10.1002/dmrr.2721

Cited by 13 publications

(14 citation statements)

References 25 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, we observed that patients with a FH of diabetes were diagnosed at an earlier age than those without a FH of diabetes. These results were consistent with a series of previous studies 9–13 . Additionally, in this study, a maternal history of diabetes had a significant adverse effect on glycaemic control in T2D patients aged <60 years, and this finding suggested that people diagnosed with T2D in early life were more likely to have worse glycaemic control 21, 22 .…”

Section: Discussionsupporting

confidence: 94%

“…The prevalence of a FH of diabetes in this study was 21.3%, which was clearly less than the rates of 30.7% among Australian T2D patients (Fremantle Diabetes Study), 34% among Danish T2D patients, and 35% among Italian T2D patients 9, 23, 25 . Here, we observed that patients with a FH of diabetes were diagnosed at an earlier age than those without a FH of diabetes.…”

Section: Discussioncontrasting

confidence: 74%

“…A familial history (FH) of diabetes has extensively been reported to be associated with an earlier onset of diabetes among patients 9–13 and with a higher incidence of diabetes in the general population 14–17 . People diagnosed with early-onset type 2 diabetes (T2D) were found to face more difficulties in managing their glycaemic control and to be more likely to experience microvascular complications 18–22 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study

Wen

Qin

et al. 2017

Sci Rep

View full text Add to dashboard Cite

To investigate the association of familial history (FH) of diabetes with the glycaemic control status of patients with type 2 diabetes (T2D), a cross-sectional study using stratified cluster sampling was conducted with 20,340 diabetic patients in Jiangsu, China. In total, 21.3% of the subjects reported a FH of diabetes. Patients with a FH of diabetes showed a higher risk of poor glycaemic control (59.7%) than those without a diabetic FH (49.8%), with an odds ratio (OR) of 1.366 (P < 0.001). Glycaemic control status did not significantly differ between the T2D patients with parental FH and those with sibling FH. Compared with patients with paternal FH, patients with maternal FH had a higher risk of poor glycaemic control (OR = 1.611, P = 0.013). Stratified analyses showed that a FH of diabetes was significantly associated with poor glycaemic control among T2D patients with a low education level (P < 0.05). In the <60 years old, overweight, and low level of physical activity groups, patients with a maternal history of diabetes showed a higher risk of poor glycaemic control than those without a FH (P < 0.05). In conclusion, FH of diabetes, especially a maternal history, had an independently adverse effect on the glycaemic control of T2D patients.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussioncontrasting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study

Wen

Qin

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…In the InterAct study, the hazard ratios associated with a firstdegree family history of diabetes were 2.64 for men and 2.77 for women, essentially identical [2]. By contrast, in two cross-sectional studies of people with Type 2 diabetes, more women than men had a parental transmission of diabetes [3,4].In the present study, we analyzed incident diabetes in men and women according to the presence of diabetes in first-and second-degree family members, and in particular in their father and their mother. The impact of a genetic risk score with 65 diabetes-related loci and maternal transmission of diabetes was also investigated.…”

mentioning

confidence: 99%

Transmission of Type 2 diabetes to sons and daughters: the D.E.S.I.R. cohort

et al. 2017

View full text Add to dashboard Cite

Aims To document the family transmission of Type 2 diabetes to men and women.Method The French D.E.S.I.R. cohort followed men and women over 9 years, with 3-yearly testing for incident Type 2 diabetes. First-and/or second-degree family histories of diabetes were available for 2187 men and 2282 women. Ageadjusted hazard ratios were estimated for various family members and groupings of family members, as well as for a genetic diabetes risk score, based on 65 diabetes-associated loci.Results Over 9 years, 136 men and 63 women had incident Type 2 diabetes. The hazard ratios for diabetes associated with having a first-degree family member with diabetes (parents, siblings, children) differed between men [1.21 (95% CI 0.80, 1.85)] and women [3.02 (95% CI 1.83, 4.99); P interaction =0.006]. The genetic risk score was predictive of diabetes in both men and women, with similar hazard ratios 1.10 (95% CI 1.06, 1.15) and 1.08 (95% CI 1.02, 1.14) respectively, for each additional at-risk allele. In women, the risk associated with having a family member with diabetes persisted after adjusting for the genetic score.Conclusion Women with a family history of diabetes (paternal or maternal) were at risk of developing Type 2 diabetes and this risk was independent of a genetic score; in contrast, for men, there was no association. Diabetes screening and prevention may need to more specifically target women with diabetes in their family, but further studies are required as the number of people with diabetes in this study was small. Diabet. Med. 34, 1615-1622 (2017 IntroductionThe transmission of Type 2 diabetes within the family is well established. In the Framingham Offspring Study, the odds ratios for offspring to have diabetes were 3.5 or 3.4 if the father or the mother has diabetes, respectively, and 6.1 if both have diabetes [1]; in the European InterAct study, these hazard ratios were 3.17 and 2.88 respectively, and 5.14 if both parents have diabetes [2].As discussed by Meigs et al.[1], some studies, but not all, have shown that diabetes is maternally rather than paternally transmitted; however, few studies have assessed family transmission according to the sex of the index case. In the InterAct study, the hazard ratios associated with a firstdegree family history of diabetes were 2.64 for men and 2.77 for women, essentially identical [2]. By contrast, in two cross-sectional studies of people with Type 2 diabetes, more women than men had a parental transmission of diabetes [3,4].In the present study, we analyzed incident diabetes in men and women according to the presence of diabetes in first-and second-degree family members, and in particular in their father and their mother. The impact of a genetic risk score with 65 diabetes-related loci and maternal transmission of diabetes was also investigated. Methods Study populationThe present cohort study used data from the Epidemiological Study on Insulin Resistance syndrome (D.E.S.I.R.) including 1994-1996 [5]. Participants were recruited from volunteers attending free-of...

show abstract

Early‐onset type 2 diabetes: Age gradient in clinical and behavioural risk factors in 5115 persons with newly diagnosed type 2 diabetes—Results from the DD2 study

Thomsen

Nielsen

et al. 2017

Diabetes Metabolism Res

View full text Add to dashboard Cite

show abstract

Association of parental history of type 2 diabetes with age, lifestyle, anthropometric factors, and clinical severity at type 2 diabetes diagnosis: results from the DD2 study

Abstract: The lack of an association between parental history and adverse lifestyle factors indicates that T2D patients do not inherit a particular propensity for overeating or inactivity, whereas patients with a parental history may have more severe pancreatic beta cell dysfunction at diagnosis.

Cited by 13 publications

References 25 publications

Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study

Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study

Transmission of Type 2 diabetes to sons and daughters: the D.E.S.I.R. cohort

Early‐onset type 2 diabetes: Age gradient in clinical and behavioural risk factors in 5115 persons with newly diagnosed type 2 diabetes—Results from the DD2 study

Contact Info

Product

Resources

About