Association of PAI-1 4G/5G and -844G/A Gene Polymorphisms and Changes in PAI-1/Tissue Plasminogen Activator Levels in Myocardial Infarction: A Case–Control Study

Abboud, Nesrine; Ghazouani, Lakhdar; Saidi, Sarra; Ben-Hadj-Khalifa, Sonia; Addad, Fawzi; Almawi, Wassim Y.; Mahjoub, Touhami

doi:10.1089/gtmb.2009.0039

Cited by 35 publications

(40 citation statements)

References 24 publications

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“…Polymorphisms which have been presented below may be the cause of inherited thrombophilia and may result in pregnancy loss. The hypothesis is based on a number of cardiology studies which have confirmed the involvement of these polymorphisms in thrombotic incidents [11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Correlation between factor VII and PAI-1 genetic variants and recurrent miscarriage

Barlik

Seremak‐Mrozikiewicz²,

Drews³

et al. 2016

Ginekol Pol

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Section: Introductionmentioning

confidence: 99%

Correlation between factor VII and PAI-1 genetic variants and recurrent miscarriage

Barlik

Seremak‐Mrozikiewicz²,

Drews³

et al. 2016

Ginekol Pol

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“…In 2009, Isordia-Salas I et al found that the 4G allele is an independent risk factor for acute MI in young patients, similar to smoking, hypertension, and a family history of inherited cardiovascular disease in Mexico [5]. In 2010, Abboud N et al found that the MI risk is notably high in 4 G carriers with elevated plasma PAI-1 in a Tunisian population [6]. However, in 2011, Rallidis LS et al found that the 4 G allele of PAI-1 4G/5G polymorphism is less frequent among very young survivors of MI compared with that in matched controls in Greece [7].…”

Section: Introductionmentioning

confidence: 99%

Plasminogen Activator Inhibitor-1 4G/5G Gene Polymorphism and Coronary Artery Disease in the Chinese Han Population: A Meta-Analysis

2012

PLoS ONE

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BackgroundThe polymorphism of plasminogen activator inhibitor-1 (PAI-1) 4G/5G gene has been indicated to be correlated with coronary artery disease (CAD) susceptibility, but study results are still debatable.Objective and MethodsThe present meta-analysis was performed to investigate the association between PAI-1 4G/5G gene polymorphism and CAD in the Chinese Han population. A total of 879 CAD patients and 628 controls from eight separate studies were involved. The pooled odds ratio (OR) for the distribution of the 4G allele frequency of PAI-1 4G/5G gene and its corresponding 95% confidence interval (CI) was assessed by the random effect model.ResultsThe distribution of the 4 G allele frequency was 0.61 for the CAD group and 0.51 for the control group. The association between PAI-1 4G/5G gene polymorphism and CAD in the Chinese Han population was significant under an allelic genetic model (OR = 1.70, 95% CI = 1.18 to 2.44, P = 0.004). The heterogeneity test was also significant (P<0.0001). Meta-regression was performed to explore the heterogeneity source. Among the confounding factors, the heterogeneity could be explained by the publication year (P = 0.017), study region (P = 0.014), control group sample size (P = 0.011), total sample size (P = 0.011), and ratio of the case to the control group sample size (RR) (P = 0.019). In a stratified analysis by the total sample size, significantly increased risk was only detected in subgroup 2 under an allelic genetic model (OR = 1.93, 95% CI = 1.09 to 3.35, P = 0.02).ConclusionsIn the Chinese Han population, PAI-1 4G/5G gene polymorphism was implied to be associated with increased CAD risk. Carriers of the 4G allele of the PAI-1 4G/5G gene might predispose to CAD.

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“…For instance, the meta analysis results suggest that it was the 5G/5G genotype, and not 4G/4G, that was associated with an increased stroke risk, although its carriers decreased the plasma PAI 1 levels [9]. On the other hand, the 4G/4G genotype has been clearly associated with increased myocardial infarction risks [9,27]. There are also other possible explanations of this contradiction.…”

Section: Discussionmentioning

confidence: 98%

“…As a result, the thrombolytic activity is downregulated, and the risk of thrombus formation grows. Several studies have shown that 4G/4G homozygotes by the -675 4G/5G polymorphisms have an increased risk of thrombosis and myocardial infarction [25][26][27]. It is also known that the plasma levels of PAI 1 grow significantly in the course of a stroke, leading to the depletion of the patient's fibrin olytic system [1].…”

Section: Discussionmentioning

confidence: 99%

Association of polymophisms of renin-angiotensin and hemostasis system genes with ischemic stroke in Russians from central Russia

et al. 2012

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The allele and genotype frequencies of 14 SNPs of renin-angiotensin (REN, AGT, AGTR1, AGTR2, BKR2, and ADRB2) and hemostasis (FGB, F2, F5, F7, ITGB3, SERPINE1, MTHFR) system genes, as well as of the ACE insertion-deletion polymorphism, were analyzed in patients with ischemic stroke and in healthy controls matched by age, sex, and ethnicity. Genotyping was performed through the amplification of the selected gene sequences and subsequent hybridization of the labeled fragments with SNP specific DNA probes on the biochip. There were no significant differences in the allele frequencies of individual genes between the groups of stroke patients and healthy donors. The contribution of the renin-angiotensin and hemostasis system genes to the genetic susceptibility to ischemic stroke in Russians from central Russia was also assessed using the MDR (Multifactor Dimensionality Reduction) approach. The genotype combination FGB G/-x ACE I/-x MTHFR C/-x SERPINE1 5G/5G, the frequency of which was significantly higher in patients with stroke than in healthy controls, was associated with an increased risk of ischemic stroke (P = 0.03, OR = 2.4, 95%CI 1.1-5.3).

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Association of PAI-1 4G/5G and -844G/A Gene Polymorphisms and Changes in PAI-1/Tissue Plasminogen Activator Levels in Myocardial Infarction: A Case–Control Study

Abstract: This study indicated that the risk of MI was notably high in 4G and -844A carriers with elevated plasma PAI-1 and were associated with reduced tPA levels.

Cited by 35 publications

References 24 publications

Correlation between factor VII and PAI-1 genetic variants and recurrent miscarriage

Correlation between factor VII and PAI-1 genetic variants and recurrent miscarriage

Plasminogen Activator Inhibitor-1 4G/5G Gene Polymorphism and Coronary Artery Disease in the Chinese Han Population: A Meta-Analysis

Association of polymophisms of renin-angiotensin and hemostasis system genes with ischemic stroke in Russians from central Russia

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