Association of p53 and MDM2 polymorphisms with risk of human papillomavirus (HPV)-related esophageal squamous cell carcinoma (ESCC)

Role of Human papilloma virus Infection and Altered Methylation of Specific Genes in Esophageal Cancer

“…Several reports are available on mutations and polymorphisms involving p53 and Aurora A gene in esophageal carcinogenesis (Katiyar et al, 2004;Yang et al, 2013). However, epigenetic changes in specific genes in the esophageal tissue due to its direct interaction with exogenous factors are limited (Chava et al, 2011).…”

“…De Villers et al (2004 reported that the prevalence of the high risk type HPV 16 was 9.8% in normal/inflammatory esophageal mucosa but was 47.6% in ESCC, where as the low risk HPV 11 was present in 28.9% of the carcinoma, 37.3% of normal/inflammatory, 66.7% of dysplastic samples. Viral load of HPV was not significantly different in the esophageal cancer tissue from different geographical locations and this does not seem to contribute to high incidence of ESCC (Castillo et al, 2013;Liu et al, 2013). Persistence of high-risk types in a small number of cases which progress to esophageal cancer could account for a lower percentage of HPV in our cancer samples, but further details can be given about it after performing HPV sub-typing in our positive samples, which is our future plan of work.…”

“…Epigenetic modifications such as methylation and acetylation are known to affect p53 expression and protein function Schroeder and Mass, 1997;Hodge et al, 2005;Ibrahim et al, 2010). Aurora A also interferes with p53 suppressor function by MDM2-mediated degradation of p53 in cancer cell lines causing inactivation of its transcriptional activity (Katayama et al, 2004;Liu et al, 2004;Yang et al, 2013). Gillison et al (2000) reported that p53 mutation was predominant in HPV negative tumors as compared to HPV positive tumors, indirectly relating the presence of HPV with disease outcome.…”

TP53 Codon 72 Genetic Polymorphism, rs1042522, Modifies the Association Between Tobacco Smoking and Breast Cancer Risk

“…In studies conducted in other cancers, Yang et al reported that p53 Arg/Arg or Arg/Pro genotype in association with HPV16-seropositivity increases the risk of esophageal squamous cell carcinoma especially in smokers (P < 0.001, OR 27.05, 95% CI 11.06 -66.16) (24). In southern India, Devi et al reported that smokers with Arg/Pro genotype are more prone to lung cancer (25).…”

Analysis of TP53 Polymorphisms in North Indian Sporadic Esophageal Cancer Patients

“…However, contradictory data is available, where few studies reported an association while several studies found no association. Positive association between p.R72P polymorphism and EC have previously reported in European and Asian (Kawaguchi et al, 2000), Chinese (Lee et al, 2000;Li et al, 2002;Lu et al, 2004;He et al, 2005;Hong et al, 2005;Cai et al, 2006;Shao et al, 2008;Yang et al, 2008;Ma et al, 2012;Yang et al, 2013), South African (Vos et al, 2003), German (Pantelis et al, 2007), Caucasian (Cescon et al, 2009;Renouf et al, 2013) and Korean (Piao et al, 2011) population. Still other studies which have failed to demonstrate any association between codon 72 variants of TP53 and EC cancer risk have been in Chinese (Guimaraes et al, 2001;Hu et al, 2003), Japanese (Hamajima et al, 2002) and Caucasian (Liu et al, 2010) …”