Association of Oxytocin with Glucose Intolerance and Inflammation Biomarkers in Metabolic Syndrome Patients with and without Prediabetes

Akour, Amal; Kasabri, Violet; Bulatova, Nailya; Muhaissen, Suha Al; Naffa, Randa; Fahmawi, Hiba; Momani, Munther; Zayed, Ayman A.; Bustanji, Yasser

doi:10.1900/rds.2017.14.364

Cited by 22 publications

(17 citation statements)

References 25 publications

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“…Alisties was one of the most abundant genera of bacteria in mouse intestine and could ferment glucose and lactate to propionate, acetate, and succinate (Brown et al., ). These short chain fatty acids modulated the release of gut hormones controlling insulin release and appetite (Akour et al., ) In the previous study, the diet‐treated groups showed increased Lachnospiraceae_NK4A136_group (Shang et al., ) A metagenomic study found that some of the genes belonging to Akkermansia muciniphila were enriched in type 2 diabetic subjects (Qin et al., ). Here, we found that E. prolifera flavonoids significantly changed the gut microbiota composition with an increased proportion of Bacteroidetes and a decreased amount of the phylum Firmicutes .…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic Potential of Green Seaweed Enteromorpha prolifera Flavonoids Regulating Insulin Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice

Yan

Yang

Lin

et al. 2018

Journal of Food Science

106

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This study aimed to investigate the antidiabetic activity of water–ethanol extract of green macroalgae Enteromorpha prolifera (EPW) and its flavonoid‐rich fraction less than 3 kDa (EPW3) in type 2 diabetic mice induced by streptozotocin and a high‐sucrose/high‐fat diet. The major active compounds were identified using ultra‐performance liquid chromatography coupled with quadrupole‐time‐of‐flight‐tandem mass spectrometry. Quantitative gene expression analysis of the insulin signaling pathway was performed. The effects of EPW3 on gut microflora in diabetic mice were analyzed by high‐throughput 16S rRNA gene sequencing. The results showed EPW3 treatment decreased the fasting blood glucose, improved oral glucose tolerance, and protected against liver and kidney injury with reduced inflammation in diabetic mice. The active principle of EPW3 revealed hypoglycemic effect as indicated by activation of the IRS1/PI3K/AKT and inhibition of the JNK1/2 insulin pathway in liver. Furthermore, the treatment significantly enriched the abundance of Lachnospiraceae and Alisties, which were positive correlation of metabolic phenotypes. These findings indicated that EPW3 possessed great therapeutic potential as adjuvant therapy for type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic Potential of Green Seaweed Enteromorpha prolifera Flavonoids Regulating Insulin Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice

Yan

Yang

Lin

et al. 2018

Journal of Food Science

106

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“…In a large sample of men with metabolic syndrome, oxytocin concentrations were elevated compared with healthy controls, whereas the obese subjects of the present experiment displayed lower baseline oxytocin levels than their lean counterparts. Decreased oxytocin concentrations were reported in patients with metabolic syndrome or diabetes mellitus, suggesting a certain degree of oxytocin deficiency in diabetic patients . However, our preliminary finding of a positive relationship between HOMA‐IR and baseline oxytocin concentrations in the obese subjects argues against this assumption.…”

Section: Discussionmentioning

confidence: 68%

“…Decreased oxytocin concentrations were reported in patients with metabolic syndrome or diabetes mellitus, 10,11,15,16 suggesting a certain degree of oxytocin deficiency in diabetic patients. 1 However, our preliminary finding of a positive relationship between HOMA-IR and baseline oxytocin concentrations in the obese subjects argues against this assumption.…”

Section: Counter-regulatory Hormones Nefa Energy Expenditure and mentioning

confidence: 99%

Intranasal oxytocin fails to acutely improve glucose metabolism in obese men

Brede

Fehr

Man

et al. 2018

Diabetes Obesity Metabolism

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The hypothalamic neuropeptide oxytocin not only modulates psychosocial function, but also contributes to metabolic regulation. We have recently shown that intranasal oxytocin acutely improves beta-cell responsivity and glucose tolerance in normal-weight men. In the present experiment, we investigated the acute glucoregulatory impact of oxytocin in obese men with impaired insulin sensitivity. Fifteen obese healthy men with an average body mass index of 35 kg/m and an average body fat content of 33% received a single intranasal dose (24 IU) of oxytocin before undergoing an oral glucose tolerance test. Results were analysed according to the oral minimal model and compared with our findings in normal-weight participants. In contrast to the results in normal-weight subjects, oxytocin did not blunt postprandial glucose and insulin excursions in obese men, and moreover failed to enhance beta-cell responsivity and glucose tolerance. These results indicate that pronounced obesity may be associated with a certain degree of resistance to the glucoregulatory impact of exogenous oxytocin, and underlines the need for further investigations into the potential of oxytocin to improve glucose homeostasis in the clinical context.

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“…For the second biomarker used in this study, PAI-1, reports in the literature indicate that the level of PAI-1 is associated with inflammation [ 44 ]. PAI-1 is also closely associated with endothelial dysfunction, as shown in different conditions [ 45 ], including in CV ischaemic disease and myocardial infarction [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Significant decrease of von Willebrand factor and plasminogen activator inhibitor-1 by providing supplementation with selenium and coenzyme Q10 to an elderly population with a low selenium status

et al. 2020

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Purpose Endothelial dysfunction and inflammation are conditions which fuel atherosclerosis and ischaemic heart disease. We have previously reported reduced cardiovascular (CV) mortality following supplementation with selenium and coenzyme Q10 to 443 elderly individuals with low selenium status (mean 67 μg/L) for 4 years. Here, we wanted to evaluate a possible association between the supplementation and the plasma concentrations of the von Willebrand factor (vWf), and the plasminogen activator inhibitor-1 (PAI-1), as they, besides other functions, are also strongly associated with endothelial function. Methods In this sub-study, 308 individuals (active substance: 157, placebo: 151) were included. Blood samples were drawn after 6 and 36 months and vWf and PAI-1 were determined in plasma by ELISA. Changes in concentrations of the biomarkers were evaluated by the use of T tests, repeated measures of variance, and ANCOVA analyses. Results The active treatment group presented a lower level of vWf after 36 months compared with the placebo group (1.08 U/mL vs. 5.10 U/mL; p = 0.0007). The results were validated through the repeated measures of variance evaluation. The PAI-1 levels showed an equally significant decrease in the active group (26.2 ng/mL vs. 49.2 ng/mL; p = 0.0002) and were also validated through repeated measures of variance evaluation. Conclusion In this sub-study on elderly receiving selenium and coenzyme Q10, or placebo we found significantly lower levels of vWf and PAI-1 in the active treatment group as compared to the placebo group. We interpret this as a better endothelial function because of the intervention, which accords with a previous finding of reduced CV mortality.

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Association of Oxytocin with Glucose Intolerance and Inflammation Biomarkers in Metabolic Syndrome Patients with and without Prediabetes

Abstract: OXT may be a substantial surrogate predictive/prognostic tool and putative pharmacotherapeutic target in metabolic anomalies and related disorders.

Cited by 22 publications

References 25 publications

Antidiabetic Potential of Green Seaweed Enteromorpha prolifera Flavonoids Regulating Insulin Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice

Antidiabetic Potential of Green Seaweed Enteromorpha prolifera Flavonoids Regulating Insulin Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice

Intranasal oxytocin fails to acutely improve glucose metabolism in obese men

Significant decrease of von Willebrand factor and plasminogen activator inhibitor-1 by providing supplementation with selenium and coenzyme Q10 to an elderly population with a low selenium status

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