Association of oxytocin levels and oxytocin receptor gene polymorphism (rs2254298) with cardiovascular risk factors in Brazilian elderly from Primary Health Care

Jacondino, Camila Bittencourt; Borges, Cristiane Alves; Rosemberg, Laura Schlater; Silva, Irênio Gomes da; Correa, Bruna da Luz; Gottlieb, Maria Gabriela Valle

doi:10.1016/j.archger.2019.103903

Cited by 9 publications

(4 citation statements)

References 40 publications

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“…In the pairwise correlation and clustering analysis, the food intake cluster (energy intake, sugar intake, and food weight) was positively associated with oxytocin-specific polygenic scores, and the body fat cluster (body mass index, trunk fat, and total body fat) pointed to a positive association with the polygenic scores of oxytocin, diabetes, and schizophrenia [326]. Additionally, although not fully proven in schizophrenia, oxytocin receptor gene polymorphism, including rs53576 [327] and rs2254298 [328], was found to play an important role in glucose homeostasis [326].…”

Section: Oxytocin Dysfunction As a Common Mechanism Underlying Schizo...mentioning

confidence: 96%

Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction

Goh

Chen

et al. 2022

IJMS

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The high prevalence of metabolic syndrome in persons with schizophrenia has spurred investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis dysfunction is present across multiple organ systems. On this account, schizophrenia may be a multisystem disorder in which one organ system is predominantly affected and where other organ systems are also concurrently involved. Growing evidence of the overlapping neurobiological profiles of metabolic risk factors and psychiatric symptoms, such as an association with cognitive dysfunction, altered autonomic nervous system regulation, desynchrony in the resting-state default mode network, and shared genetic liability, suggest that metabolic syndrome and schizophrenia are connected via common pathways that are central to schizophrenia pathogenesis, which may be underpinned by oxytocin system dysfunction. Oxytocin, a hormone that involves in the mechanisms of food intake and metabolic homeostasis, may partly explain this piece of the puzzle in the mechanism underlying this association. Given its prosocial and anorexigenic properties, oxytocin has been administered intranasally to investigate its therapeutic potential in schizophrenia and obesity. Although the pathophysiology and mechanisms of oxytocinergic dysfunction in metabolic syndrome and schizophrenia are both complex and it is still too early to draw a conclusion upon, oxytocinergic dysfunction may yield a new mechanistic insight into schizophrenia pathogenesis and treatment.

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Section: Oxytocin Dysfunction As a Common Mechanism Underlying Schizo...mentioning

confidence: 96%

Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction

Goh

Chen

et al. 2022

IJMS

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“…No significant associations were found between the OXTR gene polymorphism and cardiovascular risk factors [ 149 ]. Such a conclusion on the lack of considerable correlations between OXTR genotype and cardiovascular disease was corroborated in studies, indicating that the rs2268498 SNP in the OXTR gene is not a risk factor for hypertension [ 150 ].…”

Section: Oxtr In Cardiovascular Diseasesmentioning

confidence: 99%

Roles of the Oxytocin Receptor (OXTR) in Human Diseases

Pierzynowska

Gaffke

Żabińska

et al. 2023

IJMS

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The oxytocin receptor (OXTR), encoded by the OXTR gene, is responsible for the signal transduction after binding its ligand, oxytocin. Although this signaling is primarily involved in controlling maternal behavior, it was demonstrated that OXTR also plays a role in the development of the nervous system. Therefore, it is not a surprise that both the ligand and the receptor are involved in the modulation of behaviors, especially those related to sexual, social, and stress-induced activities. As in the case of every regulatory system, any disturbances in the structures or functions of oxytocin and OXTR may lead to the development or modulation of various diseases related to the regulated functions, which in this case include either mental problems (autism, depression, schizophrenia, obsessive-compulsive disorders) or those related to the functioning of reproductive organs (endometriosis, uterine adenomyosis, premature birth). Nevertheless, OXTR abnormalities are also connected to other diseases, including cancer, cardiac disorders, osteoporosis, and obesity. Recent reports indicated that the changes in the levels of OXTR and the formation of its aggregates may influence the course of some inherited metabolic diseases, such as mucopolysaccharidoses. In this review, the involvement of OXTR dysfunctions and OXTR polymorphisms in the development of different diseases is summarized and discussed. The analysis of published results led us to suggest that changes in OXTR expression and OXTR abundance and activity are not specific to individual diseases, but rather they influence processes (mostly related to behavioral changes) that might modulate the course of various disorders. Moreover, a possible explanation of the discrepancies in the published results of effects of the OXTR gene polymorphisms and methylation on different diseases is proposed.

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“…However, in the field of government purchasing elderly care services, the existing research on risks are all qualitative, which are about determining the risk factors. In addition, the risk research related to elderly care service [26][27][28] also provides a useful reference for this study. However, the risk research of elderly care services mainly focuses on service institutions, which belongs to the micro level and static research category.…”

Section: Literature Reviewmentioning

confidence: 99%

Anti-Risk Ability of Government Purchasing Elderly Care Services under the Coordination of Complex Network and GERT

Zhang

2022

Mathematical Problems in Engineering

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Risk problems of government purchasing elderly care services occur frequently. In order to open the “black box” of decision-making regarding the risks, this study explores the anti-risk ability of government purchasing elderly care services from the perspective of complex network and graphical evaluation review technique (GERT). Firstly, network of government purchasing elderly care services is established, which consists of link level and level of risk factors. Secondly, GERT is employed to analyze the anti-risk ability of the link level of the policy. Then combined with complex network theory, propagation process of risks is simulated at the level of risk factors and anti-risk ability of the complex network consisting of risk factors is explored. Results show that the anti-risk ability of each link in government purchasing elderly care services is obtained, which provides the priority for managers to conduct the risk management. And compared with the ani-risk ability under the random risk attack and deliberate risk attack, the anti-risk ability under the risk attack based on links is obviously lower.

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Association of oxytocin levels and oxytocin receptor gene polymorphism (rs2254298) with cardiovascular risk factors in Brazilian elderly from Primary Health Care

Cited by 9 publications

References 40 publications

Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction

Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction

Roles of the Oxytocin Receptor (OXTR) in Human Diseases

Anti-Risk Ability of Government Purchasing Elderly Care Services under the Coordination of Complex Network and GERT

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