Association of oxidative stress and PON1 with LDL and HDL particle size in middle‐aged subjects

Vekić, Jelena; Kotur‐Stevuljević, Jelena; Jelić‐Ivanović, Zorana; Spasić, Slavica; Spasojević‐Kalimanovska, Vesna; Topić, Aleksandra; Stefanović, Aleksandra; Z̆unić, Gordana

doi:10.1111/j.1365-2362.2007.01849.x

Cited by 48 publications

(35 citation statements)

References 53 publications

(67 reference statements)

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“…Consistent with our findings, NLA was also increased in patients with coronary artery disease (CAD) (24). Recent studies have shown that HDLs from CAD patients enriched in PON1 (53) and proatherogenic small and density LDLs tend to be associated with increased PON1 activity (54). Based on these findings, we speculate that PCOS-related changes in the HDL composition and presence of proatherogenic lipidemia could, at least partly, be associated with a compensatory stimulation of PON1 lactonase activity.…”

Section: Discussionsupporting

confidence: 78%

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Zhang

Liu

et al. 2015

European Journal of Endocrinology

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Objective: To study the relationship between the lactonase activities and status of paraoxonase 1 (PON1) and its association with the PON1 genetic polymorphisms in women with polycystic ovarian syndrome (PCOS). Design: A case-control study. Methods: A total of 455 PCOS patients and 441 control women were included in this study. The lactonase activities and concentrations of PON1 were assayed using 5-thiobutyl butyrolactone (TBBL) and 7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin (DEPCyMC) respectively. A normalized lactonase activity (NLA) was estimated based on the ratio of TBBLase:DEPCyMCase activity. The PON1 genotypes, serum malondialdehyde (MDA) levels and total antioxidant capacity were analyzed. Results: The lactonase activities and levels of PON1 were higher in PCOS patients than in the control women. However, the NLA did not significantly differ between groups. The K108C/T variation of the PON1 gene showed decreased lactonase activities and levels of PON1 in a genotype-dependent manner (CCOCTOTT); the 192Q/R variation of the PON1 gene showed increased PON1 lactonase activities and NLA; and the 55L/M variation of the PON1 gene showed decreased lactonase activities and levels of PON1 but an increased NLA. A multivariable regression analysis showed that the K108C/T, 192Q/R, and 55L/M variations of the PON1 gene, serum apolipoprotein A1, and MDA levels were significant predictors of PON1 lactonase activity, PON1 level, and NLA. Conclusions: The serum lactonase activities and concentrations of PON1 are increased in PCOS patients. The increased oxidative stress and the K108C/T, 192Q/R, and 55L/M genetic polymorphisms of PON1 may be associated with these changes.

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Section: Discussionsupporting

confidence: 78%

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Zhang

Liu

et al. 2015

European Journal of Endocrinology

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“…As one of the components of metabolic syndrome, dyslipidemia is linked to chronic low-grade inflammation [5], oxidative stress [6,7], and insulin resistance [8], all of which may enhance CRC carcinogenesis. Ghandehari et al [9] using the National Health and Nutrition Examination Survey (NHANES) 2003-2004 data among US adults aged 20 and older found that nearly 51.4 million US adults demonstrated undesirable levels of high-density lipoprotein cholesterol (HDL cholesterol) and triglyceride and 36.1 million elevated low-density lipoprotein cholesterol (LDL cholesterol).…”

Section: Introductionmentioning

confidence: 99%

Dyslipidemia and colorectal cancer risk: a meta-analysis of prospective studies

Yao

Tian

2014

Cancer Causes Control

105

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This meta-analysis of prospective studies suggests that dyslipidemia, especially high levels of serum triglyceride and total cholesterol, is associated with an increased risk of colorectal cancer, whereas high-density lipoprotein cholesterol might associate with a decreased risk of colorectal cancer. Further studies are warranted to determine whether altering the concentrations of these metabolic variables may reduce colorectal cancer risk.

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“…Fernandez et al [54] showed that HDL-C concentration was directly correlated to HDL diameter increase. According to Vekic et al [55] larger lipoprotein diameter subclasses (HDL2a and HDL2b) are negatively correlated with CVD. By contrast, smaller ones (HDL3a, HDL3b and HDL3c) are positively correlated.…”

Section: F S Marques Et Al Journal Of Biophysical Chemistrymentioning

confidence: 98%

Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i> Incorporation of Phospholipids

Marques¹,

Silva²,

Mattoso³

et al. 2017

JBPC

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End stage-renal-disease (ESRD) is associated with dyslipidemia and premature atherosclerosis. The study evaluates the effect of hemodialysis (HD) on HDL-remodeling between pre-and post-HD. Was conducted a cross-sectional study with 50 ESRD male patients, undergoing HD at Ana Neri Hospital, Salvador, Brazil. All individuals were on HD for at least 3 months, into a three sessions protocol for 3 -4 hours per week, with a polysulfone low-flow basicdialyzing-membrane and unfractionated-heparin. HDL Phospholipid-incorporation was measured by 14 C-PL-scintillation-counting, expressed as % 14 C-PL/mL/hour. Paraoxonase (PON-1) activity was measured by spectrophotometry using paraoxon as substrate. Cardiovascular risk ratios and atherogenic index of plasma were calculated. Total cholesterol, HDL-C and non-HDL-C increased at post-HD on all age groups, but without triglycerides (TG) changes. TG/HDL-C decreased in 30 -39 and 40 -49 year (y) at post-HD (p < 0.05). LDL-C/apoB increased in >60 y, after HD (p < 0.05). HDL-C/apo-AI increased in 40 -49 y (p < 0. C-PL-incorporation was reduced in >60 y (p < 0.05), when compared to pre-and post-HD. ESRD patients undergoing HD shows important changes on lipid-profile, PON-1-activity, cardiac risk ratios and HDL-remodeling. These results demonstrate the influence of HD with a polysulfone low-flow basic-dialyzing-membrane and unfractionated-heparin on lipoprotein metabolism.

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Association of oxidative stress and PON1 with LDL and HDL particle size in middle‐aged subjects

Cited by 48 publications

References 53 publications

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Dyslipidemia and colorectal cancer risk: a meta-analysis of prospective studies

Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i> Incorporation of Phospholipids

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Association of oxidative stress and PON1 with LDL and HDL particle size in middle‐aged subjects

Cited by 48 publications

References 53 publications

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Dyslipidemia and colorectal cancer risk: a meta-analysis of prospective studies

Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and &lt;i&gt;in Vitro&lt;/i&gt; Incorporation of Phospholipids

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Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i> Incorporation of Phospholipids