Association of oxidative stress and paraoxonase status with PROCAM risk score

Stefanović, Aleksandra; Kotur‐Stevuljević, Jelena; Spasić, Slavica; Vekić, Jelena; Bujišić, Nada

doi:10.1016/j.clinbiochem.2009.01.008

Cited by 13 publications

(9 citation statements)

References 36 publications

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“…In our study, only two strategies showed outstanding discriminative abilities: the model consisting of FRS plus SOD and the best-case model (FRS, SOD plus O2 -), with AUC values of 0.906 and 0.924, respectively ( Table 2). This finding implies that the addition of oxidative stress/antioxidative defense markers to traditional cardiovascular risk factors provides enhanced overall predictive power and is consistent with our earlier observations [38,39]. According to our results, the addition of lipid markers to the FRS did not improve patient stratification ( Table 2).…”

Section: Discussionsupporting

confidence: 92%

A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis

Lakic¹,

Bogavac-Stanojević²,

Jelić‐Ivanović³

et al. 2010

Value in Health

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Section: Discussionsupporting

confidence: 92%

A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis

Lakic¹,

Bogavac-Stanojević²,

Jelić‐Ivanović³

et al. 2010

Value in Health

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“…At the beginning of our research, the serum lipid levels of total cholesterol, triglycerides and LDL-cholesterol were higher than in the previously mentioned studies [27][28][29][30][31], except in the IM-PROVE-dyslipidemia study because this study was done on dyslipidemic patients and the effect of lipid level correction was estimated after sixmonth treatment [21]. After one-year treatment, a significant correction of all examined lipid parameters was found in our patients, so the total cholesterol was 5.74 mmol/l, triglycerides -1.48 mmol/l, LDL-cholesterol -3.70 mmol/l, while the level of protective HDL-cholesterol rose to 1.35 mmol/l.…”

Section: Discussioncontrasting

confidence: 54%

“…However, since none of these score systems is ideal in prediction, the decision was to apply two other mostly used coronary risk scores Framingham (original, modified according to ATP III and computer Weibul model) and PROCAM (original, modified according to MONICA and computer Cox Hazards model) besides SCORE in our research. Similar studies used Framingham and SCORE [28], only Framingham [29] or just PROCAM [30] risk score schemes in our population. In the IMPROVE-dyslipidemia study [21], Framingham and PROCAM risk scores were applied for the estimation; while in Co-Laus study [27], the original Framigham scores and the one recalibrated for Swiss population were used.…”

Section: Discussionmentioning

confidence: 99%

Effect of serum lipid level change on 10-year coronary heart risk distribution estimated by means of seven different coronary risk scores during one-year treatment

Eremić-Kojić¹,

Djeric²,

Dejanovic

2014

Med pregl

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Introduction. This study was done in order to evaluate the effect of serum levels of total cholesterol, triglycerides, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol on 10-year coronary heart disease risk distribution change. Material and Methods. This study included 110 subjects of both genders (71 female and 39 male), aged 29 to 73, treated at the Outpatient Department of Atherosclerosis Prevention, Centre for Laboratory Medicine, Clinical Centre Vojvodina. The 10-year coronary heart disease risk was estimated on first examination and after one-year treatment by means of Framingham, PROCAM and SCORE coronary risk scores and their modifications (Framingham Adult Treatment Panel III, Framingham Weibul, PRO-CAM NS and PROCAM Cox Hazards). Age, gender, systolic and diastolic blood pressure, smoking, positive family history and left ventricular hypertrophy are risk factors involved in the estimation of coronary heart disease besides lipid parameters. Results. There were no significant differences in nutritional status, smoking habits, systolic and diastolic pressure, and no development of diabetes mellitus or cardiovascular incidents during oneyear follow. However, a significant reduction in cholesterol level (p<0.001), triglycerides (p<0.001), low-density lipoprotein cholesterol (p<0.001) and an increase in high-density lipoprotein cholesterol (p<0.02) was present although therapeutic target values were not achieved. In addition, a significant increase was observed in the category of low 10-year coronary heart disease risk (Framingham-p<0.001; Framingham ATP III-p<0.001; Framingham Weibul-p<0.001; PROCAM-p<0.05; PROCAM NS-p<0.05; PROCAM Cox Hazards-p<0.001; SCORE-p<0.001) and a reduction in high-risk category (Framingham-p<0.001; Framingham ATP III-p<0.005; Framingham Weibul-p<0.005; PRO-CAM-p<0.001; PROCAM NS-p<0.001; PROCAM Cox Hazards-p<0.001; SCORE-p<0.005) in comparison with the risk at the beginning of the study. Conclusion. Our results show that the correction of lipid level after one-year treatment leads to a significant redistribution of 10-year coronary heart disease risk estimated by means of seven different coronary risk scores. This should stimulate patients and doctors to persist in prevention measures. SažetakUvod. Ovo istraživanje izvedeno je sa ciljem ispitivanja uticaja promena serumskih koncentracija ukupnog holesterola, triglicerida, holesterola u lipoproteinima male gustine i holesterola u proteinima velike gustine na promenu distribucije 10-godišnjeg rizika za koronarnu bolest srca. Materijal i metode. U ispitivanje je uključeno 110 ispitanika, 71 žena i 39 muškaraca, starosti 29−73 godine, upućenih u Ambulantu za prevenciju ateroskleroze Centra za laboratorijsku medicinu Kliničkog centra Vojvodine. Procena 10-godišnjeg koronarnog rizika vršena je bazalno i nakon godinu dana lečenja pomoću Framingamskog, PROCAM i SCORE bodovnog sistema i njihovih modifikacija (Framingham ATP III, Framingham Weibul, PROCAM NS i PROCAM Cox Hazards). Pored parametara lipidskog status...

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“…Multiple studies investigated the influence of particular PON1 alleles on the development of various diseases particularly on cardiovascular disease, however, they did not give definite results [23,31,32].…”

Section: Introductionmentioning

confidence: 99%

Original article Paraoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia

Bednarska-Makaruk¹,

Krzywkowski²,

Graban³

et al. 2013

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Association of oxidative stress and paraoxonase status with PROCAM risk score

Cited by 13 publications

References 36 publications

A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis

A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis

Effect of serum lipid level change on 10-year coronary heart risk distribution estimated by means of seven different coronary risk scores during one-year treatment

Original article Paraoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia

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