Association of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis patients using fixed-dose combination therapy in Contagem, Minas Gerais, Brazil

Viegas, Ana Maria; Miranda, Silvana Spíndola de; Haddad, João Paulo Amaral; Ceccato, Maria das Graças Braga; Carvalho, Wânia da Silva

doi:10.1590/s1678-9946201759028

Cited by 12 publications

(18 citation statements)

References 14 publications

(17 reference statements)

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“…Pulmonary TB was predominant (60.6%), followed by extrapulmonary TB (28.9%). A similar result of 62.7% was observed in a study carried out in the city of Contagem, Minas Gerais State 20 . In a national-based study, a similar result was also observed, between 37% and 40% for extrapulmonary TB, and 59% and 62% for pulmonary TB 21 .…”

Section: Discussionsupporting

confidence: 83%

Characteristics of cases of tuberculosis coinfected with HIV in Minas Gerais State in 2016

Castro

Scatena

Miranzi

et al. 2019

Rev. Inst. Med. trop. S. Paulo

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This study aimed to characterize the cases of tuberculosis (TB) co-infected with the human immunodeficiency virus (HIV) in Minas Gerais State, Brazil, after the notification sheet modification, and to verify the association between the new variables and the treatment outcome. It is an analytical cross-sectional study with TB/HIV cases notified in the year 2016 to the Brazilian Information System for Notifiable Diseases ( Sistema de Informação de Agravos de Notificação ). Descriptive statistics, chi-square test, and multiple correspondence analysis were performed to verify the association between the outcome, ageand associated diseases. Of the 180 cases, most were male (75.6%) between 30 and 49 years old (63.3%), mixed ethnicity (black and white) (49.4%), 94.4% had the Acquired Immunodeficiency Syndrome (AIDS) and 60.6% had pulmonary TB. The molecular test was not performed at the time of diagnosis in 70.5% of the cases. Homeless people (4.4%) and prisoners (3.9%) featured prominently among the special populations. People between 40 and 49 years old without concurrent diseases were cured in 40.0% of the cases; 18.9% abandoned the treatment due to smoking, drug abuse and mental illness in the age group between 20 and 29 years old. The deaths were associated with the age group between 30 and 39 years old and the occurrence of AIDS. The results have shown that the groups considered vulnerable (drug users, smokers and people with mental illness) abandoned the treatment, the notification upon death from AIDS in adults was late and some treatments were inadequate. The epidemiological surveillance, prevention and assistance strategies towards cases of TB/HIV must be improved in order to achieve the goal of the Brazilian National Plan to end Tuberculosis as a Public Health Problem until 2035 in the state.

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Section: Discussionsupporting

confidence: 83%

Characteristics of cases of tuberculosis coinfected with HIV in Minas Gerais State in 2016

Castro

Scatena

Miranzi

et al. 2019

Rev. Inst. Med. trop. S. Paulo

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“…11,[14][15][16][17][18][19][20][21] Population sizes ranged from 83 to 2416 patients, with mean age varying between 32.7 and 61.2 years. 18,22,23 The number of males was higher than females in all but two studies. 14,19 Patients were mostly treated using a daily dosage of isoniazid, rifampicin, pyrazinamide and ethambutol.…”

Section: Study Characteristicsmentioning

confidence: 71%

Clinical and economic impact of medication non-adherence in drug-susceptible tuberculosis: a systematic review

Chimeh

Gafar

Pradipta

et al. 2020

int j tuberc lung dis

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BACKGROUND: Despite considerable efforts to globally eradicate TB, and the availability of effective antibiotics, TB elimination goals are falling behind. While non-adherence to TB drug regimens may compromise effective treatment, its full impact is still unknown.OBJECTIVE: To determine the clinical and economic impact of non-adherence to TB medication on treatment outcomes in drug-susceptible TB patients (DS-TB).METHODS: A systematic review was performed using PubMed and Embase for studies published between 2009 and 2019 reporting associations between adherence and WHO-defined TB treatment outcomes and economic outcomes in DS-TB patients.RESULTS: A total of 14 studies were included. Eight focused on the association between non-adherence and death, 2 on treatment failure, 1 study on successful treatment outcome, 1 study on both successful and unsuccessful treatment outcomes and 2 on cost outcomes. Most studies (71.4%) were retrospective cohort or case-control studies. The results showed that non-adherence to TB drug regimens was associated with death, treatment failure and lower cure rates.CONCLUSION: Non-adherence to TB drugs has a profound impact on both clinical and economic TB outcomes. To reach WHO TB elimination goals, preventing non-adherence and the implementation of cost-effective intervention programmes should receive the highest priority.

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“…Thus, this factor may ultimately undermine treatment success (Munro et al 2007, Arbex et al 2010. Several studies have demonstrated the need to monitor patients who consume alcohol (Campani et al 2011, Oliveira and Antunes 2012, Silveira et al 2012, Viegas et al 2017. This study included six alcoholic patients, but this characteristic did not influence treatment outcome because all patients were ultimately cured.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the impact of pharmaceutical care for tuberculosis patients in a Secondary Referral Outpatient Clinic, Minas Gerais, Brazil

Lopes

Miranda

Ceccato

et al. 2017

An. Acad. Bras. Ciênc.

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Pharmaceutical care is a professional practice seeking the responsible provision of drug therapy by identifying, resolving, and preventing Drug-Related Problems (DRP). The study aims to describe and evaluate the impact of pharmaceutical care given to patients being treated for tuberculosis (TB). Study concurrent, longitudinal, prospective conducted during pharmaceutical care in the TB outpatient clinic, Clinical Hospital, Federal University of Minas Gerais during the period August 2009 to July 2012. The Pharmacotherapy Workup proposed by Cipolle et al. (2004) was used. Statistical analyses were performed by X 2 or Fisher exact test, as appropriate. A total of 62 patients were followed up, and 128 drug-related problems (DRP) were identified: 69.5% related to safety, 13.3% to effectiveness, 12.5% to indication, and 4.7% to treatment adherence, and 62.1% of the DRP were resolved. A total of 115 pharmaceutical interventions were performed. The impact of pharmaceutical care was satisfactory for 73.9% of patients with a resolution rate of 77%. There was a greater impact on pharmaceutical care (index ≥ 0.50) for those patients who were not smokers (p <0.05). The impact of pharmaceutical care was important, so the pharmacist should work alongside the multidisciplinary team to monitor treatment and perform interventions.

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Association of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis patients using fixed-dose combination therapy in Contagem, Minas Gerais, Brazil

Cited by 12 publications

References 14 publications

Characteristics of cases of tuberculosis coinfected with HIV in Minas Gerais State in 2016

Characteristics of cases of tuberculosis coinfected with HIV in Minas Gerais State in 2016

Clinical and economic impact of medication non-adherence in drug-susceptible tuberculosis: a systematic review

Evaluation of the impact of pharmaceutical care for tuberculosis patients in a Secondary Referral Outpatient Clinic, Minas Gerais, Brazil

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