Association of osteopontin regulatory polymorphisms with systemic sclerosis

Barizzone, Nadia; Marchini, Maurizio; Cappiello, Francesco Liberato; Chiocchetti, Annalisa; Orilieri, Elisabetta; Ferrante, Daniela; Corrado, Lucia; Mellone, Simona; Scorza, Raffaella; Dianzani, Umberto; D’Alfonso, Sandra

doi:10.1016/j.humimm.2011.06.009

Cited by 32 publications

(16 citation statements)

References 33 publications

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“…14 Subsequently, in another study, serum OPN levels have been determined to be higher in patients with SSc compared to the HC group. 13 Similarly, in our study, serum OPN levels were higher in the SSc group.…”

Section: Resultssupporting

confidence: 75%

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Serum osteopontin and vitronectin levels in systemic sclerosis

et al. 2017

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Section: Resultssupporting

confidence: 75%

“…[9][10][11] Furthermore, OPN gene expression has been reported to be increased in SSc. 12,13 In addition, serum OPN levels are demonstrated to be higher in SSc.…”

Section: Introductionmentioning

confidence: 99%

Serum osteopontin and vitronectin levels in systemic sclerosis

et al. 2017

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“…Osteopontin (OPN) is a pleiotropic proinflammatory cytokine promoting chronic inflammatory processes in various systemic autoimmune diseases such as RA, juvenile idiopathic arthritis, SLE, systemic sclerosis and multiple sclerosis [85][86][87][88][89][90]. In RA, where high levels of OPN are supposed to play a role in bone erosion, the presence of anti-OPN AAbs has been described and was inversely correlated with biological markers of disease activity [91].…”

Section: Anti-osteopontin Autoantibodiesmentioning

confidence: 99%

Emerging clinical phenotypes associated with anti-cytokine autoantibodies

Vincent

Plawecki

Goulabchand

et al. 2015

Autoimmunity Reviews

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“…The association between OPN gene polymorphisms and SSc susceptibility in humans has been investigated in a study of Barizzone et al [82]. The group analyzed the association of two OPN SNPs: −156G/GG and +1239A/C and serum level of OPN in Italian SSc patients and controls.…”

Section: Systemic Sclerosismentioning

confidence: 99%

Osteopontin (OPN) Gene Polymorphisms and Autoimmune Diseases

Kaleta¹

2017

Genetic Polymorphisms

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Osteopontin (OPN) is a pleiotropic protein, important in bone remodeling and immune system signaling. OPN is synthesized in a variety of cells and tissues. It can be found not only in bone cells but also in immune cells (B and T lymphocytes, natural killer (NK) cells, natural killer T (NKT) cells, macrophages, neutrophils, and dendritic cells). OPN regulates T-helper 1/T-helper 2 (Th1/Th2) balance, stimulates B cells to antibodies production, regulates macrophages and neutrophils function, and activates dendritic cells. A number of factors, including hormones, cytokines, and polymorphisms of promoter region of OPN gene, regulate protein expression. OPN and variants of the OPN gene have been associated with the pathogenesis of multiple disorders, including systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, systemic sclerosis, inlammatory bowel diseases, asthma, type 1 diabetes, and many other. However, some studies gave diferent or inconclusive results. Thus, the role of OPN polymorphic variants in autoimmune diseases needs to be beter deined and explored as a diagnostic and therapeutic target to monitor and treat immune-mediated conditions.

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Association of osteopontin regulatory polymorphisms with systemic sclerosis

Cited by 32 publications

References 33 publications

Serum osteopontin and vitronectin levels in systemic sclerosis

Serum osteopontin and vitronectin levels in systemic sclerosis

Emerging clinical phenotypes associated with anti-cytokine autoantibodies

Osteopontin (OPN) Gene Polymorphisms and Autoimmune Diseases

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