Association of organophosphate ester exposure with cardiovascular disease among US adults: Cross-sectional findings from the 2011–2018 National Health and Nutrition Examination Survey

Guo, Xianwei; Wu, Birong; Xia, Weihang; Gao, Juan; Xie, Peng; Feng, Linya; Sun, Chenyu; Liang, Mingming; Zhao, Dongdong; Ma, Shaodi; Liu, Haixia; Lowe, Scott W.; Bentley, Rachel; Huang, Christy; Qu, Guangbo; Sun, Yehuan

doi:10.1016/j.chemosphere.2022.136428

Cited by 17 publications

(14 citation statements)

References 86 publications

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“…Based on the presented results, exposure to TBP and TBOEP may influence the pathogenesis of CHD. This result contradicts observations from the 2011–2018 NHANES study which were not indicative of a significant association between OFR exposure and CHD risk …”

Section: Resultscontrasting

confidence: 98%

“…This result contradicts observations from the 2011−2018 NHANES study which were not indicative of a significant association between OFR exposure and CHD risk. 18 Our finding in single exposure analysis was consistent with observations among 180 subjects recruited from 2008 to 2011 in Taiwan, China; more specifically, urinary mEHP (median: 6.56 and 6.69 μg/g creatinine for controls and cases, respectively) was found to be associated with an elevated risk of CHD. 16 While according to WQS regression, mEHP was not identified as a significant contributor in exposure mixtures.…”

Section: Associations Between Exposure To a Single Edc And Chd Risksupporting

confidence: 90%

“…13 However, there is scarce evidence supporting this association, and the mechanisms through which PAH metabolites are connected to CHD have not been elucidated. So far, there is no solid evidence that exposure to OFRs, despite demonstrating potential cardiovascular toxicity, 18 is associated with a risk of developing CHD. Moreover, the observed association between exposure to OFRs and metabolic syndrome risk was inconsistent across different groups of individuals, and needs further research.…”

Section: Introductionmentioning

confidence: 99%

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Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters, Phthalates, and Polycyclic Aromatic Hydrocarbons

Zhang,

Liu,

et al. 2024

Environ. Health

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There is a lack of human evidence concerning the cardiovascular effects of combined exposure to endocrine disruptors. This case-control study sought to investigate coronary heart disease (CHD) associations with exposure to organophosphate flame retardants (OFRs), phthalates (PAEs), and polycyclic aromatic hydrocarbons (PAHs) among 148 adults with coronary-angiography-diagnosed CHD and 320 healthy adults from southern China. The mediating role of glucose-lipid metabolism was also explored. Bayesian kernel machine regression suggested that when exposure status was fixed to the 75th percentile with the median value as the reference, exposure to OFRs, PAEs, and PAHs was associated with an 84% (95% CI: 36%−134%), 132% (12%−252%), and 214% (89%−331%) increased risk of developing CHD, respectively. Weighted quantile sum regression indicated urinary bis(2-butoxyethyl) phosphate (BBOEP), dibutyl phosphate (DBP), monoisononyl phthalate (miNP), and metabolites of phenanthrene may be major contributors to the overall effect of mixtures. In further analyses on identified chemical risk factors, mediation analyses suggested exposure to phenanthrene may increase the risk of CHD via elevating total cholesterol and blood glucose, while exposure to DiNP mainly associates with serum lipids. Besides, we observed a slight mediation effect of oxidative DNA damage between urinary BBOEP and risk of CHD. These results provide potential direction for further experimental studies. Longitudinal evidence is needed to clarify the causation of the results.

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Section: Resultscontrasting

confidence: 98%

Section: Associations Between Exposure To a Single Edc And Chd Risksupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters, Phthalates, and Polycyclic Aromatic Hydrocarbons

Zhang,

Liu,

et al. 2024

Environ. Health

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“…Elevated CHO and TG levels were reported to be associated with a serious cardiovascular disease, suggesting that the lipid accumulation induced by OPE exposure probably poses health threat to silver carp. Actually, it was verified that exposure to mixed OPEs was positively related to the increased prevalence of cardiovascular disease among US adults . Consistent with the above phenomenon, triphenyl phosphate (TPHP) exposure led to significant increases in the concentrations of TG and CHO in mice kidney .…”

Section: Resultsmentioning

confidence: 63%

“…Actually, it was verified that exposure to mixed OPEs was positively related to the increased prevalence of cardiovascular disease among US adults. 29 Consistent with the above phenomenon, triphenyl phosphate (TPHP) exposure led to significant increases in the concentrations of TG and CHO in mice kidney. 30 Moreover, TPHP and tricresyl phosphate (TCrP) treatment also resulted in TG and CHO deposition in human hepatocellular cells, 31 which further supported our finding of lipid accumulation induced by OPEs.…”

Section: Ope-induced Lipid Metabolism Disorder In Laboratory Exposurementioning

confidence: 59%

Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River

Liu,

Zhang,

et al. 2024

Environ. Sci. Technol.

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The Yangtze River fishery resources have declined strongly over the past few decades. One suspected reason for the decline in fishery productivity, including silver carp (Hypophthalmichthys molitrix), has been linked to organophosphate esters (OPEs) contaminant exposure. In this study, the adverse effect of OPEs on lipid metabolism in silver carp captured from the Yangtze River was examined, and our results indicated that muscle concentrations of the OPEs were positively associated with serum cholesterol and total lipid levels. In vivo laboratory results revealed that exposure to environmental concentrations of OPEs significantly increased the concentrations of triglyceride, cholesterol, and total lipid levels. Lipidome analysis further confirmed the lipid metabolism dysfunction induced by OPEs, and glycerophospholipids and sphingolipids were the most affected lipids. Hepatic transcriptomic analysis found that OPEs caused significant alterations in the transcription of genes involved in lipid metabolism. Pathways associated with lipid homeostasis, including the peroxisome proliferator-activated receptor (PPAR) signal pathway, cholesterol metabolism, fatty acid biosynthesis, and steroid biosynthesis, were significantly changed. Furthermore, the affinities of OPEs were different, but the 11 OPEs tested could bind with PPARγ, suggesting that OPEs could disrupt lipid metabolism by interacting with PPARγ. Overall, this study highlighted the harmful effects of OPEs on wild fish and provided mechanistic insights into OPE-induced metabolic disorders.

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Combined exposure to multiple dioxins and dioxin-like polychlorinated biphenyls on hypertension among US adults in NHANES: a cross-sectional study under three statistical models

Guo

Feng

et al. 2022

Environ Sci Pollut Res

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Association of organophosphate ester exposure with cardiovascular disease among US adults: Cross-sectional findings from the 2011–2018 National Health and Nutrition Examination Survey

Cited by 17 publications

References 86 publications

Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters, Phthalates, and Polycyclic Aromatic Hydrocarbons

Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters, Phthalates, and Polycyclic Aromatic Hydrocarbons

Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River

Combined exposure to multiple dioxins and dioxin-like polychlorinated biphenyls on hypertension among US adults in NHANES: a cross-sectional study under three statistical models

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