Association of Oral Fat Sensitivity with Body Mass Index, Taste Preference, and Eating Habits in Healthy Japanese Young Adults

Asano, Masanobu; Hong, Guang; Matsuyama, Yusuke; Wang, Weiqi; Izumi, Shin-ichi; Izumi, Masayuki; Tsuruo, Takashi; Kudo, Tada Aki

doi:10.1620/tjem.238.93

Cited by 28 publications

(50 citation statements)

References 37 publications

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“…During the data analysis portion of this study, another study concluded that there was a positive association between fatty acid taste sensitivity and BMI [50]. This study was not included in the analysis as there were only 2 overweight and 0 obese individuals tested.…”

Section: Discussionmentioning

confidence: 99%

Comparisons of Fatty Acid Taste Detection Thresholds in People Who Are Lean vs. Overweight or Obese: A Systematic Review and Meta-Analysis

et al. 2017

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Given the increasing evidence that supports the ability of humans to taste non-esterified fatty acids (NEFA), recent studies have sought to determine if relationships exist between oral sensitivity to NEFA (measured as thresholds), food intake and obesity. Published findings suggest there is either no association or an inverse association. A systematic review and meta-analysis was conducted to determine if differences in fatty acid taste sensitivity or intensity ratings exist between individuals who are lean or obese. A total of 7 studies that reported measurement of taste sensations to non-esterified fatty acids by psychophysical methods (e.g.,studies using model systems rather than foods, detection thresholds as measured by a 3-alternative forced choice ascending methodology were included in the meta-analysis. Two other studies that measured intensity ratings to graded suprathreshold NEFA concentrations were evaluated qualitatively. No significant differences in fatty acid taste thresholds or intensity were observed. Thus, differences in fatty acid taste sensitivity do not appear to precede or result from obesity.

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Section: Discussionmentioning

confidence: 99%

Comparisons of Fatty Acid Taste Detection Thresholds in People Who Are Lean vs. Overweight or Obese: A Systematic Review and Meta-Analysis

et al. 2017

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“…Previously, we reported that healthy young Japanese adults who sense satiety easily after food intake have a lower threshold for OA (Asano et al 2016). We also reported that the saliva flow rate was raised by OA stimulation in the oral cavity in healthy young adults (Izumi et al 2016).…”

Section: Introductionmentioning

confidence: 70%

“…In fact, accumulating evidence indicates that long-chain fatty acids, such as oleic acid (OA, C 18 H 34 O 2 , a monounsaturated fatty acid found in many vegetable and animal oils), elicits a unique, perceptive sensation at concentrations relevant to the modern food supply (Running et al 2015). Several studies have reported a difference in the OA detection threshold among human individuals and an inverse correlation between the body mass index (BMI; the weight in kilograms divided by the square of the height in meters [kg/m 2 ]) and oral fat sensitivity (OFS), the ability to taste fat (Stewart et al 2010(Stewart et al , 2011Haryono et al 2014;Martínez-Ruiz et al 2014;Asano et al 2016). However, other studies failed to detect a significant association between BMI and OFS (Tucker et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…The reasons for the contradictory results are largely unknown, and more studies in this area are essential for a better understanding of the topic (Martínez-Ruiz et al 2014). On the other hand, several studies proposed that fatty acid taste sensitivity is associated with fatty food consumption (Stewart et al 2010(Stewart et al , 2011 or other eating habits, including satiety after food intake (Asano et al 2016;Costanzo et al 2017), suggesting the existence of unique regulatory mechanisms of OFS in the body. In addition, an intervention study showed that fat taste threshold increased when participants were exposed to a low-fat diet over a four-week period.…”

Section: Introductionmentioning

confidence: 99%

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Oral Fat Sensitivity Is Associated with Social Support for Stress Coping in Young Adult Men

Tanaka

Hong

Tominami

et al. 2018

Tohoku J. Exp. Med.

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Oral fat sensitivity (OFS), the ability to taste fat, is associated with eating habits in humans, including daily fatty food consumption; namely, proper OFS is important for health. In addition, lifestyle factors, such as stress and sleep, may affect fat intake. However, correlations between OFS, stress management, and sleep are largely unknown. Thus, we investigated the associations of OFS with lifestyle factors regarding stress management and daytime sleepiness in healthy young adult men. We measured OFS, sensitivities for three prototypical tastes (sweet, salty, and sour), and BMI in 22 subjects (27.2 ± 6.0 years), who also completed a self-reported questionnaire on health, including lifestyle-related questions. The correlations of taste sensitivities with stress management and daytime sleepiness were analyzed. We thus found that the number of mentors for personal concerns (a question regarding stress management, social support) was positively associated with OFS (P = 0.041), but not the other taste sensitivities. In contrast, other lifestyle factors related to stress management (frequency of relaxation, frequency of eating when irritated or worried, and degree of satisfaction with one's sleep) and daytime sleepiness were not significantly associated with OFS, similar to that observed for other tested taste sensitivities. These results characterize the unique association of OFS with the degree of social support in healthy young men and provide novel insights into the nature of individual OFS differences. Thus, measuring the degree of social support may be helpful for the evaluation of OFS impairment, thereby contributing to the prevention of stress-induced overeating.

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“…Numerous studies report reduced orosensory fat perception (i.e. hyposensitivity) in obese people [31–42]. A potential mechanism for this hyposensitivity is the lingual CD36 receptor, which is located primarily on the circumvallate papillae (CV) of the tongue, and is considered the fat taste receptor.…”

Section: Introductionmentioning

confidence: 99%

Lingual CD36 and nutritional status differentially regulate fat preference in obesity-prone and obesity-resistant rats

Braymer

Zachary

Schreiber

et al. 2017

Physiology & Behavior

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Lingual fatty acid receptors (i.e. CD36) mediate the orosensory perception of fat/fatty acids and may contribute to the susceptibility to develop obesity. The current study tested the hypothesis that fat/fatty acid preference in obesity-prone (OP, Osborne-Mendel) and obesity-resistant (OR, S5B/Pl) rats is mediated by nutritional status and lingual CD36. To determine if nutritional status affected linoleic acid (LA) preference in OP and OR rats, rats were either fasted overnight or fed a high fat diet (60% kcal from fat). In OR rats, fasting increased the preference for higher concentrations of LA (1.0%), while consumption of a high fat diet decreased LA preference. In OP rats, fasting increased the preference for lower concentrations of LA (0.25%), however high fat diet consumption did not alter LA preference. To determine if lingual CD36 mediated the effects of an overnight fast on LA preference, the expression of lingual CD36 mRNA was assessed and the effect of lingual application of CD36 siRNA on LA preference was determined. Fasting increased lingual CD36 mRNA expression in OR rats, but failed to alter lingual CD36 mRNA in OP rats. Following an overnight fast, application of lingual CD36 siRNA led to a decrease in LA preference in OR, but not OP rats. Lingual application of CD36 siRNA was also used to determine if lingual CD36 mediated the intake and preference for a high fat diet in OP and OR rats. CD36 siRNA decreased the preference and intake of high fat diet in OR rats, but not OP rats. The results from this study suggest that the dysregulation of lingual CD36 in OP rats is a potential factor leading to increased fat intake and fat preference and an enhanced susceptibility to develop obesity.

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Association of Oral Fat Sensitivity with Body Mass Index, Taste Preference, and Eating Habits in Healthy Japanese Young Adults

Cited by 28 publications

References 37 publications

Comparisons of Fatty Acid Taste Detection Thresholds in People Who Are Lean vs. Overweight or Obese: A Systematic Review and Meta-Analysis

Comparisons of Fatty Acid Taste Detection Thresholds in People Who Are Lean vs. Overweight or Obese: A Systematic Review and Meta-Analysis

Oral Fat Sensitivity Is Associated with Social Support for Stress Coping in Young Adult Men

Lingual CD36 and nutritional status differentially regulate fat preference in obesity-prone and obesity-resistant rats

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