Association of Ophthalmologic Disorders and Depression in the Elderly

McCusker, Scott; Koola, Maju Mathew

doi:10.4088/pcc.14r01731

“…Increasing life expectancy rates in high-income countries (3) are expected to dramatically raise the prevalence of visual impairment and subsequent need for eye-care services and associated health care costs for years to come (4). Global health is also greatly impacted by mental health issues (5), especially in older adults (6) and in those with visual impairment (7)(8)(9)(10)(11). The prevalence of depression in older adults with visual impairment is estimated to approximate a staggering 30%, compared to roughly 11% in control groups (12,13).…”

Section: Introductionmentioning

confidence: 99%

Mastery and self-esteem mediate the association between visual acuity and mental health: a population-based longitudinal cohort study

Maaswinkel

¹

,

Aa

²

,

Rens

³

et al. 2020

Preprint

0

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Background: With deteriorating eyesight, people often become dependent on others for many aspects of their daily lives. As a result, they feel less ‘in control’ and experience lower self-esteem. Lower sense of mastery and self-esteem are known to predict depression, but their roles in people with visual impairment have only marginally been investigated. Therefore, this study aimed to determine the influence of mastery and self-esteem on the relationship between visual acuity and mental health.Methods: A longitudinal cohort study was performed using data from the Longitudinal Aging Study Amsterdam (LASA), collected between 2001 and 2012. A community-based population of 2599 older adults (mean age 72 years) were included, who were randomly selected from population registers. Outcomes of interest were the Pearlin Mastery Scale, Rosenberg Self-Esteem Scale, Center for Epidemiologic Studies – Depression scale and the Hospital Anxiety Depression Scale – Anxiety subscale. Linear mixed models were used to establish the association between visual acuity and mental health over time.Results: Mean age was 72 years, 56% was female and 1.2% qualified as having low vision. Visual impairment was associated with a lower sense of mastery (β = -0.477, p < 0.001), lower self-esteem (β = -0.166, p = 0.008) and more depression (β = 0.235, p < 0.001). No significant association between visual acuity and anxiety was found. The relationship between visual acuity and depression was mediated by self-esteem (25%) and sense of mastery (79%).Conclusions: Vision loss was associated with depression. This association was mediated by self-esteem and sense of mastery. This provides us with new possibilities to identify, support and treat those at risk for developing depression by aiming to increase their self-esteem and sense of mastery.

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“…Increasing life expectancy rates in high-income countries (3) are expected to dramatically raise the prevalence of visual impairment and subsequent need for eye-care services and associated health care costs for years to come (4). Global health is also greatly impacted by mental health issues (5), especially in older adults (6) and in those with visual impairment (7)(8)(9)(10)(11). The prevalence of depression in older adults with visual impairment is estimated to approximate a staggering 30%, compared to roughly 11% in control groups (12,13).…”

Section: Introductionmentioning

confidence: 99%

Mastery and self-esteem mediate the association between visual acuity and mental health: a population-based longitudinal cohort study

Maaswinkel

¹

,

Aa

²

,

Rens

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background: With deteriorating eyesight, people often become dependent on others for many aspects of their daily lives. As a result, they feel less ‘in control’ and experience lower self-esteem. Lower sense of mastery and self-esteem are known to predict depression, but their roles in people with visual impairment have only marginally been investigated. Therefore, this study aimed to determine the influence of mastery and self-esteem on the relationship between visual acuity and mental health.Methods: A longitudinal cohort study was performed using data from the Longitudinal Aging Study Amsterdam (LASA), collected between 2001 and 2012. A community-based population of 2599 older adults (mean age 72 years) were included, who were randomly selected from population registers. Outcomes of interest were the Pearlin Mastery Scale, Rosenberg Self-Esteem Scale, Center for Epidemiologic Studies – Depression scale and the Hospital Anxiety Depression Scale – Anxiety subscale. Linear mixed models were used to establish the association between visual acuity and mental health over time.Results: Mean age was 72 years, 56% was female and 1.2% qualified as having low vision. Visual impairment was associated with a lower sense of mastery (β = -0.477, p < 0.001), lower self-esteem (β = -0.166, p = 0.008) and more depression (β = 0.235, p < 0.001). No significant association between visual acuity and anxiety was found. The relationship between visual acuity and depression was mediated by self-esteem (25%) and sense of mastery (79%).Conclusions: Vision loss was associated with depression. This association was mediated by self-esteem and sense of mastery. This provides us with new possibilities to identify, support and treat those at risk for developing depression by aiming to increase their self-esteem and sense of mastery.

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“…Ocular disorders are widespread in both developing and developed countries . According to the statistics reported by the World Health Organization, approximately 314 million people are visually impaired, and among these, 45 million people are blind .…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNAs in ocular diseases: new and potential therapeutic targets

Zhang

¹

,

Dong

²

,

Wang

³

et al. 2019

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Long non‐coding RNAs (lncRNAs) are non‐protein coding transcripts containing more than 200 nucleotides. In the past, lncRNAs were considered as ‘transcript noise’ or ‘pseudogenes’ and were thus ignored. However, in recent years, lncRNAs have been proven to regulate gene expression at the epigenetic, transcriptional and translational level, and thereby influence cell proliferation, apoptosis, viability, immune response and oxidative stress. Furthermore, increasing evidence points to their involvement in different diseases, including cancer and heart diseases. Recently, lncRNAs were shown to be differentially expressed in ocular tissues and play a significant role in the pathogenesis of ophthalmological disorders such as glaucoma, corneal diseases, cataract, diabetic retinopathy, proliferative vitreoretinopathy and ocular tumors. In this review, we summarize the classification and mechanisms of known lncRNAs, while detailing their biological functions and roles in ocular diseases. Moreover, we provide a concise review of the clinical relevance of lncRNAs as novel, potential therapeutic targets in the treatment of eye diseases.

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Association of Ophthalmologic Disorders and Depression in the Elderly

Abstract: Greater recognition and treatment of depression in individuals with impaired vision is warranted.

Cited by 20 publications

References 24 publications

Mastery and self-esteem mediate the association between visual acuity and mental health: a population-based longitudinal cohort study

Mastery and self-esteem mediate the association between visual acuity and mental health: a population-based longitudinal cohort study

Mastery and self-esteem mediate the association between visual acuity and mental health: a population-based longitudinal cohort study

Long non‐coding RNAs in ocular diseases: new and potential therapeutic targets

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