Association of Oncogenic and Nononcogenic Human Papillomavirus With HIV Incidence

Auvert, Bertran; Lissouba, Pascale; Cutler, Ewalde; Zarca, Kevin; Puren, Adrian; Taljaard, Dirk

doi:10.1097/qai.0b013e3181b327e7

Cited by 66 publications

(65 citation statements)

References 40 publications

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“…9 Although it is universally accepted that HPV infection does not elicit a local inflammatory reaction, it has been hypothesized that HPV infection could facilitate HIV transmission through disruption of mucosal integrity and/or altered local immunosurveillance. 9,10 The interplay between HPV and HIV at genital mucosa level has been evaluated in a very limited number of studies, which used different methodologies and reached inconsistent results. 4,11 The present study aims at estimating whether the presence of cervical HPV infection and HPV viral load at cervical level may alter HIV genital shedding in HIVseropositive women.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cervical Human Papillomavirus Infection and Shedding of Human Immunodeficiency Virus in Cervicovaginal Fluids

Fornabaio

Carvalho²,

Lillo³

et al. 2012

JAIDS Journal of Acquired Immune Deficiency Syndromes

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We evaluated the association between human papillomavirus cervical infection and HIV shedding in cervicovaginal lavage fluid (CVL), studying 89 HIV-infected women recruited at the Department of Infectious Diseases of Brescia (Italy). HIV shedding in CVL was found in a similar proportion of women with (30%; 21/70) and without (31.6%; 6/19) cervical human papillomavirus infection. A statistically significant correlation was found between HIV viral load in serum and CVL among the 27 women with detectable HIV in CVL (r = 0.4; P = 0.04). However, women on highly active antiretroviral therapy were more likely to have detectable HIV-RNA in CVL despite negative viremia (80% vs. 8%; P < 0.005).

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Section: Introductionmentioning

confidence: 99%

“…A, Correlation between cervical HPV-DNA log10 and genital HIV-RNA log 10 in the group of women with cervical HPV infection (n = 70; r = 20.08). B, Quantitative correlation between cervicovaginal HIV and cervical HPV in women with HIV genital shedding (n = 27; r = 0.19).…”

mentioning

confidence: 99%

Cervical Human Papillomavirus Infection and Shedding of Human Immunodeficiency Virus in Cervicovaginal Fluids

Fornabaio

Carvalho²,

Lillo³

et al. 2012

JAIDS Journal of Acquired Immune Deficiency Syndromes

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show abstract

“…The relationship between HPV and HIV coinfection is especially important, as anal and urethral HPV infection in men significantly increases the risk for HIV acquisition and the development of anal dysplasia and cancer. 3,38 Given the high prevalence of high-risk HPV type infection, especially in HIV-coinfected MSM and in those who practice receptive or versatile anal intercourse, efforts toward decreasing the risk of HPV acquisition and increasing surveillance for HPV-related cancer in MSM are warranted.…”

mentioning

confidence: 99%

Human Papillomavirus Infection in Men Who Have Sex with Men in Lima, Peru

Quinn

Salvatierra

Solari

et al. 2012

AIDS Research and Human Retroviruses

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Human papillomavirus (HPV) infection among men who have sex with men (MSM) is the primary risk factor for anal cancer. Of 105 Peruvian MSM examined, 77.1% were infected with HPV; of these 79.0% were coinfected with two or more types and 47.3% were infected by a carcinogenic type. HPV types 53, 6, 16, and 58 were the most frequent HPV infections detected. High-risk HPV type infection was associated with sex work, HIV status, and having rectal chlamydial or gonorrheal infection. These findings support broadening HPV vaccine coverage and increasing surveillance for the development of cancer in MSM infected with HPV.

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“…Auvert and colleagues used data from male circumcision trial in South Africa to look at association between HPV and HIV incidence [16]. After controlling for other factors, there was no association between low risk HPV and HIV but there was 4 fold increased risk in men with high risk HPV and the incidence increased with number of high-risk HPV genotypes detected, a similar finding was reported among MSM in the USA where increasing numbers of anal HPV types increased HIV risk [17].…”

Section: The Association Between Sti and Hiv Acquisitionmentioning

confidence: 83%

Study of HIV Status in 400 Cases of S.T.D in Shanti ID Clinic, Vadodara, Gujarat, India

Chopra

2016

JHVRV

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The prospective study was carried out for detecting the prevalence of HIV in sexually transmitted diseases (S.T.D) cases at Shanti infectious diseases clinic at Vadodara, Gujarat, India from January 2010 to May 2013. Out of 400 cases of sexually transmitted diseases, 317 (79.23 %) were males and 83 cases (20.75%) were females. Screening of HIV test was done by Elisa test and was confirmed by Western blot test. Amongst 400 cases 300 cases (75.00%) were in age group of 20 to 50 years, 34 cases (8,55%) wer+++e of 0 to 20 years, 66 cases 916.25%) were above 50 years. Out of 400 cases 87 cases (21.75%) were syphilis, 45 cases(11.25%) were cancroid, 73 cases (18,25%) were gonorrhea, 110 cases (27.50%) were genital herpes, 11 cases (2.75%) moll -scum contagiosum 44 cases(11,00%)genital scabies, 9 cases (2.755) cytomegalovirus infection and 21 cases (5,24%) were having lympho-granuloma venerium. Out of 400 cases of sexually transmitted diseases, 67 cases (16.76%) were HIV positive, amongst which 61 cases (91.04%) were HIV1 and remaining 6 cases (8.96%) were HIV2. Although there is plausible link between STI and HIV risk, intervention studies continue to be disappointing. This does not disprove a causal link but mechanisms of action and the design and implementation of interventions need to be better understood.

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Association of Oncogenic and Nononcogenic Human Papillomavirus With HIV Incidence

Abstract: Several explanations could account for our findings. One is that HR-HPV facilitates HIV acquisition. The association of HPV with HIV acquisition requires further investigations.

Cited by 66 publications

References 40 publications

Cervical Human Papillomavirus Infection and Shedding of Human Immunodeficiency Virus in Cervicovaginal Fluids

Cervical Human Papillomavirus Infection and Shedding of Human Immunodeficiency Virus in Cervicovaginal Fluids

Human Papillomavirus Infection in Men Who Have Sex with Men in Lima, Peru

Study of HIV Status in 400 Cases of S.T.D in Shanti ID Clinic, Vadodara, Gujarat, India

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