Association of omega-3 fatty acids and homocysteine concentrations in pre-eclampsia☆

Kulkarni, Asmita; Mehendale, Savita; Pisal, Hemlata; Kilari, Anitha; Dangat, Kamini; Salunkhe, Satyajeet; Taralekar, Vaishali; Joshi, Sadhana

doi:10.1016/j.clnu.2010.07.007

Cited by 57 publications

(50 citation statements)

References 23 publications

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“…PT-PE was defined by total gestation <37 weeks and systolic and diastolic blood pressures >140 and 90 mm Hg, respectively, with the presence of proteinuria >1+ (or 300 mg/24 h) in a dipstick test at an interval of 6 h. The control group was defined by total gestation ≥37 weeks and consisted of pregnant women with no medical or obstetrical complications. Fifty-seven control women were also a part of the cohort reported earlier [9]. …”

Section: Methodsmentioning

confidence: 99%

“…A food frequency questionnaire was used to estimate the frequency of intake of foods rich in folic acid and vitamin B 12 and has been reported by us previously [9]. Intakes were available for the majority of women recruited in the study.…”

Section: Methodsmentioning

confidence: 99%

“…This was a cross-sectional design in which 76 women delivering at term (control group), 67 women delivering preterm (PT group) and 49 women with preeclampsia delivering preterm (PT-PE group) with singleton pregnancy were recruited. The inclusion and exclusion criteria were as described in our earlier studies [9,10,11]. Briefly, women were excluded from the study if there was evidence of other pregnancy complications, alcohol or drug abuse.…”

Section: Methodsmentioning

confidence: 99%

“…All participants had limited access to foods fortified with folic acid and vitamin B 12 . The food frequency questionnaire has been used by us in a number of studies on pregnant women [9,23,24]. …”

Section: Methodsmentioning

confidence: 99%

“…We recently reported increased homocysteine concentrations and altered placental global methylation levels in women with pregnancy complications such as preeclampsia and preterm delivery [9,10,11]. The observed abnormal global DNA methylation may reflect alterations in the normal temporal regulation of gene expression that is crucial for the optimal development of the fetus and may have implications for metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Reduced Folate, Increased Vitamin B<sub>12</sub> and Homocysteine Concentrations in Women Delivering Preterm

et al. 2012

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Background and Aim: Maternal nutrition is an important determinant of the duration of pregnancy and fetal growth, and thereby influences pregnancy outcome. Folic acid and vitamin B₁₂ are involved in one-carbon metabolism and are reported to underlie intrauterine programming of adult diseases. Methods: In the present study, the levels of folate, vitamin B₁₂ and homocysteine were measured in mothers delivering preterm (PT; gestation <37 weeks; n = 67), those delivering preterm due to preeclampsia (PT-PE; n = 49) and women delivering at term (control group; n = 76). Results: Increased vitamin B₁₂ and homocysteine levels (p < 0.05 for both) were seen in the PT-PE and PT groups as compared to the controls. In addition, reduced folate levels (p < 0.05) were observed in the PT group. A negative association of maternal plasma homocysteine with birth weight was seen in the idiopathic preterm group. Conclusions: Altered maternal micronutrients and resultant increased homocysteine concentrations exist in women delivering preterm. These alterations may also be partly associated with other factors such as undiagnosed inflammatory conditions or inadequate placentation in some women. Since these micronutrients play an important role in epigenetic regulation of vital genes involved in the fetal programming of adult diseases, further studies need to be undertaken to understand their role in preterm deliveries.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reduced Folate, Increased Vitamin B<sub>12</sub> and Homocysteine Concentrations in Women Delivering Preterm

et al. 2012

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Docosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, and neural tube defects in Tunisian population

Nasri,

Ben Jamaa,

Siala Gaigi

et al. 2024

Birth Defects Research

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ObjectiveTo determine the effect of maternal status in (plasma and red blood cell) folate, vitamin B12, homocysteine, and vitamin D, as well as their interaction with MTHFR (C677T and A1298C) and MTRR A66G polymorphisms, on maternal plasma docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (ARA) levels and the risk of neural tube defects (NTDs).MethodsARA, EPA, and DHA composition was assessed using capillary gas chromatography.ResultsARA and DHA levels were higher in controls than in case mothers for low plasma folate status. For low red blood cell folate status, DHA levels were higher in controls than in case mothers. For high homocysteine levels, ARA and DHA levels were higher in controls than in case mothers. NTD mothers had lower EPA and DHA levels for low vitamin B12 levels. NTD mothers had lower DHA levels for low vitamin D levels. For low plasma folate status, DHA levels in the MTHFR C677T gene and ARA and EPA levels in MTHFR A1298C gene were different among the three genotypes in case mothers. DHA levels in the MTHFR C677T gene were different among the three genotypes in case mothers for both low and high homocysteine levels. For low vitamin B12 levels, ARA and DHA levels were different among the three genotypes of the MTHFR C677T gene in case mothers. In the MTHFR C677T gene, ARA and DHA levels were different among the three genotypes in case mothers for low vitamin D levels.ConclusionsMore advanced research is required to verify a suitable biochemical parameter status in relation to the genotypes in pregnant women.

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Maternal nutrition influences angiogenesis in the placenta through peroxisome proliferator activated receptors: A novel hypothesis

Meher

Sundrani

Joshi

2015

Molecular Reproduction Devel

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SUMMARYPlacental angiogenesis is critical to maintain adequate blood flow during gestation, and any alterations in this process can result in an adverse pregnancy. Growing evidence indicates that suboptimal maternal nutrition can alter placental development. Although the underlying mechanisms are not clear, maternal nutrition likely influences the expression of genes involved in placental development through regulation of various transcription factors such as peroxisome proliferator-activated receptors (PPARs), which can be activated by ligands including long-chain polyunsaturated fatty acids. Indeed, several studies demonstrated a role for PPAR in implantation, trophoblast differentiation, and angiogenesis. Alterations in maternal nutrition during pregnancy can affect the expression of PPARs via epigenetic mechanisms or through homocysteine, which is known to compete for PPARs. This review discusses the role of maternal nutritionÀ Àparticularly micronutrients like folate, vitamin B 12 , and omega-3 fatty acidsÀ Àin modulating the activity of PPARs during placentation and angiogenesis, which affects placental and fetal growth. Additional animal and human studies need to be undertaken to elucidate the molecular mechanisms through which maternal nutrition regulates PPARs, specifically to determine whether PPARs affect placental angiogenesis directly through angiogenic factors or indirectly by modulating trophoblast differentiation.Mol. Reprod. Dev. 82: 726À734, 2015. ß

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Association of omega-3 fatty acids and homocysteine concentrations in pre-eclampsia☆

Cited by 57 publications

References 23 publications

Reduced Folate, Increased Vitamin B<sub>12</sub> and Homocysteine Concentrations in Women Delivering Preterm

Reduced Folate, Increased Vitamin B<sub>12</sub> and Homocysteine Concentrations in Women Delivering Preterm

Docosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, and neural tube defects in Tunisian population

Maternal nutrition influences angiogenesis in the placenta through peroxisome proliferator activated receptors: A novel hypothesis

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