Association of olfactory neuropathy spectrum disorder and Wolff‐Parkinson‐White syndrome: A Report of a case

Gore, Mitchell R.

doi:10.1002/ccr3.2976

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…It is also not uncommon to find other clinical manifestations, particularly cardiac in these patients. Cases of hypogonadotropic hypogonadism associated with Wolf-Parkinson-White syndrome have been reported in the literature [3,4]. Recent studies have also shown that testosterone deficiency can induce metabolic disorders such as hyperglycemia and the progression of atherosclerotic disease, particularly coronary artery disease [5,6].…”

Section: Discussionmentioning

confidence: 99%

Unusual coexistence of restrictive heart disease and Kallmann syndrome: a case report

Bennani,

Zahri,

Khaldi

et al. 2024

Egypt Heart J

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Background Kallmann–Morsier syndrome is a rare disease characterized by the association of congenital gonadotropic deficiency and anosmia or hyposmia. The cardiac manifestations associated with this syndrome are little known. Through this case, we will characterize the cardiac involvement of this disease in the light of what is already described in the literature. Case presentation We report the case of a young patient who presented with a picture of cardiac decompensation revealing restrictive heart disease. In her exploration, she was found to have primary amenorrhea, leading to the diagnosis of Kallmann syndrome. Medical treatment was optimized for the management of her cardiac decompensation as well as hormonal replacement treatment for her delayed puberty and growth. Conclusions Cardiac manifestations in Kallmann–Morsier syndrome are few reported in the literature, and restrictive heart disease is uncommon with no cases report till now. This association suggests a possible common genetic origin that should be explored in the future.

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Section: Discussionmentioning

confidence: 99%

Unusual coexistence of restrictive heart disease and Kallmann syndrome: a case report

Bennani,

Zahri,

Khaldi

et al. 2024

Egypt Heart J

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“…A recent case report [ 1 ] noted an adult patient with previously undiagnosed congenital anosmia as well as the radiographic absence of the olfactory groove/bulbs as well as Wolff-Parkinson-White syndrome. Further investigation revealed a prior case report [ 2 ] involving a patient with isolated hypogonadotropic hypogonadism, pronounced hypodontia, and the Wolff-Parkinson-White syndrome.…”

Section: Introductionmentioning

confidence: 99%

Olfactory Radioanatomical Findings in Patients With Cardiac Arrhythmias, COVID-19, and Healthy Controls

Gore¹

2022

Cureus

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Background Clinical hyposmia and anosmia are commonly seen, most frequently with either post-inflammatory, age-related, or idiopathic causes being most frequent. Actual anatomical abnormalities of the olfactory groove or olfactory bulb are far less common. A recent case report showing a possible link between congenital olfactory bulb agenesis and Wolff-Parkinson-White syndrome suggested that there may be a relationship between cardiac arrhythmia and olfactory bulb development. While Kallmann syndrome (KS) is the classic syndrome involving olfactory bulb agenesis and hypogonadotropic hypogonadism, this case report and a prior report noting isolated hypogonadotropic hypogonadism and the Wolff-Parkinson-White syndrome suggest there may be more rare associations between cardiac arrhythmia and olfactory groove abnormalities. Methods A retrospective study was conducted to attempt to elucidate whether there may be a link between cardiac arrhythmias and olfactory anatomical abnormalities. The olfactory bulb volume (OBV) and olfactory sulcus depth (OSD) of 44 patients with cardiac arrhythmias were compared to 43 healthy control patients. Additionally, 11 patients with acute COVID-19 were also compared in those groups. Patients were seen between September and December 2020. Available MRI images were utilized. Results The average right and left olfactory bulb volume was 29.42±18.17 mm 3 and 25.67±15.29 mm 3 for patients with cardiac arrhythmia, 40.79±30.65 mm 3 and 38.95±21.87mm 3 for healthy controls, and 21.30±15.23 mm 3 and 17.75±9.63 mm 3 for COVID-19 patients. The average right and left olfactory sulcus depth was 7.68±1.31 mm and 7.47±1.56 mm for patients with cardiac arrhythmia, 10.67±1.53 mm and 10.62±1.67 mm for controls, and 7.91±0.99 mm and 8.02±0.88 mm for COVID-19 patients. The right and left olfactory bulb volume difference versus controls was significant for cardiac arrhythmia patients (p=0.028 and p=0.0038) and for COVID-19 patients (p=0.047 and p=0.0029), and the right and left olfactory sulcus depth difference versus controls was significant for cardiac arrhythmia patients (p<0.0001 and p<0.0001) and for COVID-19 patients (p<0.0001 and p<0.0001). Both COVID-19 and cardiac arrhythmia patients were, on average, significantly older than controls. On multivariate analysis, cardiac arrhythmia or COVID-19 diagnosis did not significantly correlate with smaller olfactory bulb volume, but older age, cardiac arrhythmia diagnosis, and COVID-19 diagnosis did significantly correlate with smaller olfactory sulcus depth. On multivariate analysis, older age was significantly correlated with cardiac arrhythmia diagnosis and COVID-19 diagnosis. Conclusions Olfactory bulb volume and olfactory sulcus depth in both cardiac arrhythmia and COVID-19 patients appeared significantly smaller than in controls. Cardiac...

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Association of olfactory neuropathy spectrum disorder and Wolff‐Parkinson‐White syndrome: A Report of a case

Abstract: Olfactory neuropathy spectrum disorder is characterized by hyposmia or anosmia and hypoplastic or absent olfactory bulbs. There may be an association between olfactory neuropathy spectrum disorder and Wolff‐Parkinson‐White syndrome.

Cited by 2 publications

References 12 publications

Unusual coexistence of restrictive heart disease and Kallmann syndrome: a case report

Unusual coexistence of restrictive heart disease and Kallmann syndrome: a case report

Olfactory Radioanatomical Findings in Patients With Cardiac Arrhythmias, COVID-19, and Healthy Controls

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