Association of obstructive sleep apnea syndrome with hematological parameters and comorbid diseases

Abstract

Background & Objective: Obstructive sleep apnea syndrome (OSAS) has a close relationship with many diseases. Hematological parameters are simple diagnostic methods and can give an idea about severity of some diseases. The aim of this study was to examine the relationship of OSAS with comorbid diseases and relationship between OSAS severity, oxygen desaturation index (ODI) and hematological parameters. Methods: This retrospective and cross-sectional study was conducted by evaluating the medical files of patients who underwent polysomnography between 2012 and 2018. 1,119 patients (198 controls; 921 OSA) were participated to the research. Results: Congestive heart failure, hypertension (HT), asthma and chronic obstructive pulmonary diseases (COPD) were seen in 143, 424, 254 and 177 patients respectively. Severe OSAS was found more common in male. Except the patients with HT; neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) levels were higher and lymphocyte levels were lower in patients with comorbid diseases. WBC and erythrocyte distribution width (RDW) levels were higher in patients with COPD than without COPD; PLT levels were higher in patients with asthma than without asthma. WBC level of the moderate-severe OSAS was significantly higher than the control and mild OSAS (p=0.001). Platelet distribution width (PDW) value of the OSAS was higher than the control group (p=0.005). The apnea-hypopnea index and ODI levels were higher in patients with comorbidity than without comorbidity (p=0.001). Conclusions: It can be said that lymphopenia, high NLR, PLR, WBC, RDW and PDW may be useful markers for predicting severity of OSAS in comorbid diseases. The presence of OSAS should be detected in order to treat comorbidity appropriately.

Associations Between Systemic Inflammatory Markers Based on Blood Cells and Polysomnographic Factors in Obstructive Sleep Apnea

“…The prevalence of comorbidities in severe OSA may increase because of the higher level of systemic inflammation. In a retrospective study of 1,119 patients, the NLR and PLR were reported to be significantly higher in OSA patients with chronic obstructive pulmonary disease, asthma, and congestive heart failure [ 22 ]. Similarly, a metaanalysis showed that the NLR was higher in patients with OSA than in normal controls [ 9 ] and decreased after continuous positive airway pressure [ 10 ].…”

Association between Red Blood Cell Distribution Width and Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis

“…Of these, 48 were removed because they did not report the studied endpoint (n = 30), did not include the control group (n = 9), investigated pediatric cohorts (n = 4) or different patient groups (n = 2), or were not written in English (n = 3), leaving 17 articles. Since three additional records were identified from Google Scholar and reference lists, a total of 20 manuscripts [14,[44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] were included in the final analysis (Figure 1). The included studies were published between 2012 [44] and 2022 [60][61][62].…”

“…Since three additional records were identified from Google Scholar and reference lists, a total of 20 manuscripts [14,[44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] were included in the final analysis (Figure 1). The included studies were published between 2012 [44] and 2022 [60][61][62]. The majority were conducted in Turkey (n = 15) [14,[44][45][46][47][48]52,54,55,57,58,60,62], whereas the remaining (n = 5) were conducted in Spain [49], Egypt [50], Pakistan [53], China [56], and Romania [61].…”

“…The included studies were published between 2012 [44] and 2022 [60][61][62]. The majority were conducted in Turkey (n = 15) [14,[44][45][46][47][48]52,54,55,57,58,60,62], whereas the remaining (n = 5) were conducted in Spain [49], Egypt [50], Pakistan [53], China [56], and Romania [61]. Eight studies were retrospective [48,51,52,54,[56][57][58]62] (Table 1).…”

“…The majority were conducted in Turkey (n = 15) [14,[44][45][46][47][48]52,54,55,57,58,60,62], whereas the remaining (n = 5) were conducted in Spain [49], Egypt [50], Pakistan [53], China [56], and Romania [61]. Eight studies were retrospective [48,51,52,54,[56][57][58]62] (Table 1). The selected studies evaluated a total of 4528 OSAS (age 44.9 ± 11.1, 49.8% males) and 1335 non-OSAS (age 49.7 ± 10.8, 59.8% males) subjects, with an average RDW of 15.4 ± 1.5% and 14.8 ± 1.3%, respectively (Table 1).…”