Association of Obestatin, Ghrelin, and Inflammatory Cytokines in Obese Patients with Non-alcoholic Fatty Liver Disease

Estep, James M.; Abawi, Massih; Jarrar, Mohammed; Wang, Lei; Stepanova, Maria; Elariny, Hazem; Moazez, Amir H.; Goodman, Zachary; Chandhoke, Vikas; Baranova, Ancha; Younossi, Zobair M.

doi:10.1007/s11695-011-0475-1

Cited by 50 publications

(46 citation statements)

References 44 publications

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“…108 However, in patients with NAFLD and hepatitis C, DAG and AG plasma levels are shown to be higher than in normal individuals. 109,110 In addition, in humans, it was suggested that ghrelin levels should be reduced in response to the development of insulin resistance rather than being influenced by liver damage per se. 111,112 In vivo, peripheral infusion of AG inhibits insulin-induced suppression of hepatic glucose production while stimulating overall glucose uptake in mice.…”

Section: Ghrelin and Livermentioning

confidence: 99%

The endocrine effects of acylated and des-acylated ghrelin

Andrich¹,

Cianflone²,

Comtois³

et al. 2012

RRED

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Acylated ghrelin is one of the few peptides known whose isolation and characterization follow the description of its receptor and its basic biological functions. Characterized initially for its somatotrophic properties, ghrelin was shown later to exert various effects on other important physiological functions in mammals, such as appetite, gastric acid secretion, gut motility, insulin sensitivity, adiposity, and energy expenditure. Further, ghrelin influences cardiac function, reproduction, and the immune system as well. Here we present an overview of the discovery and subsequent development of ghrelin as an important peptide hormone involved in the control of energy metabolism in humans and other mammals. Recently reported effects of acylated ghrelin on glucose/lipid uptake, de novo lipogenesis, gluconeogenesis, lipid-droplet formation, fatty acid transport into mitochondria, and mitochondrial activity are particularly emphasized and discussed.

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Section: Ghrelin and Livermentioning

confidence: 99%

The endocrine effects of acylated and des-acylated ghrelin

Andrich¹,

Cianflone²,

Comtois³

et al. 2012

RRED

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“…Система грелин-обестатин участвует в патогенезе жиро-вой болезни печени (ЖБП) и фиброза печени [47]. У 75 больных ЖБП M. Estep и соавт.…”

unclassified

“…У 75 больных ЖБП M. Estep и соавт. [47] определяли уровень обестатина в сы-воротке крови и получили несомненное доказательство, что при ЖБП снижена секреция обестатина, причем это снижение гене-тически обусловлено. Система грелин-обестатин влияет на возникновение ЖКБ.…”

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The ghrelin-obestatin system in health and disease

Терещенко¹,

Kaiushev²

2014

Ter. arkh.

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“…In a recent publication by Estep et al [7], they report on the relation of the three ghrelin gene products (ghrelin, DAG, and obestatin) and their involvement in those metabolic and inflammatory pathways that are linked with the development of NAFLD. They studied 75 morbidly obese patients with biopsy-proven NAFLD (41 with histologic NASH) and found that patients with NASH had twofold higher concentration of DAG than patients with non-NASH.…”

mentioning

confidence: 99%

“…Ghrelin and obestatin concentrations positively correlated with fibrosis stage. Apparently, products of the ghrelin gene may be important for the pathogenesis of NASH and fibrosis [7].…”

mentioning

confidence: 99%