Association of Obesity With Prostate Specific Antigen and Prostate Specific Antigen Velocity in Healthy Young Men

Chang, In Ho; Han, Jun Hyun; Ahn, Seung Hyun

doi:10.1016/j.juro.2007.10.066

Cited by 12 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparing the findings of the present study with those from studies of young Eastern Asian men, the PSA values of the present study were generally lower than those observed in previous studies of Chinese and Korean men (Table 2) [32–40]. This difference has been noted previously [34,35,40,41] and is intriguing because it reflects the opposite relation observed in older men, i.e.…”

Section: Discussionsupporting

confidence: 49%

Prostate‐specific antigen concentration in young men: new estimates and review of the literature

et al. 2012

View full text Add to dashboard Cite

Study Type – Diagnostic (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Although non‐recommended PSA testing has been reported in men younger than 40 years of age, there are few recognized data on PSA in younger American men, particularly younger African‐American men, to provide age‐ and race‐specific references. Using data from an existing large study of young, male members of the US military, aged 28–36 years, the present study provides PSA reference distributions for young Caucasian‐American men (median = 0.56, 95th percentile = 1.42, range: <0.01–3.34 ng/mL) and African‐American men (median = 0.64, 95th percentile = 1.89, range: 0.12–6.45 ng/mL). Previous estimates from the literature are also summarized. OBJECTIVE To provide race‐specific prostate‐specific antigen (PSA) reference distributions for young men less than 40 years of age who might have undergone non‐recommended PSA testing because of their family history of prostate cancer or inadvertently as part of a standard panel of tests. MATERIALS AND METHODS We used data from a large existing study of young, male Caucasian‐ and African‐American members of the US military with stored serum in the Department of Defense serum repository. As part of this previous study, we selected a random sample of 373 Caucasian‐ and 366 African‐American men aged 28–36 years with an archived serum specimen collected for standard military purposes from 2004 to 2006. We measured serum total PSA concentration in this specimen using the Beckman Coulter Access Hybritech PSA assay. RESULTS The PSA level ranged from <0.01 to 3.34 ng/mL among Caucasian‐American men, with a median of 0.56 ng/mL and a 95th percentile of 1.42 ng/mL. The PSA level ranged from 0.12 to 6.45 ng/mL among African‐American men, with a median of 0.64 ng/mL and 95th percentile of 1.89 ng/mL. The PSA level was significantly higher in African‐ than in Caucasian‐American men (P= 0.001). CONCLUSION The PSA estimates, together with those summarized from the literature, provide age‐ and race‐specific PSA reference distributions for young men who might have undergone non‐recommended PSA testing. Comparisons by race could also begin to inform the timing of divergence of prostate cancer risk by race.

show abstract

Section: Discussionsupporting

confidence: 49%

Prostate‐specific antigen concentration in young men: new estimates and review of the literature

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Some investigators have indicated that an elevated BMI may be associated with a lower circulating serum PSA level [20][21][22] . Thus, men with a high BMI may be excluded from screening or early detection based on a low perceived risk of prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Prostate Cancer: Recent Trends in Korea

Hoon¹,

Chang²

2010

Urol Int

Self Cite

View full text Add to dashboard Cite

Introduction: We investigated the yearly changes in the baseline prostate-specific antigen (PSA) levels and the incidence of prostate cancer in men screened at our health promotion center from 1995 to 2008 to determine the trends in prostate cancer in Korea. Subjects and Methods: The participants were 6,007 men, who had PSA screening for the first time at the health promotion center. Changes in the baseline PSA levels, age, body mass index (BMI), and cholesterol levels were investigated. We evaluated the percentage of participants with a PSA level ≧2.0 and 4.0 ng/ml; the men were stratified by a 5-year age range, over two calendar years. In addition, we reviewed the results of their prostate biopsies. Results: The median baseline PSA level and the percentage of participants with a PSA level ≧2.0 and 4.0 ng/ml was not increased. The univariate and multivariate analyses, controlled for age and BMI, showed that two calendar years was not an independent predictive factor of the PSA level. The biopsy compliance rate increased from 36% during 1997–1998 to 70% during 2005–2006. Conclusions: The data from this study suggest that the increase in the incidence of prostate cancer might have been inaccurate in Korea.

show abstract

“…This hospital is the independent subsidiary hospital of KEPCO and has the database of health information about the employees of KEPCO. Recently, we reported that age and weight changes are associated with substantial differences in PSA velocity [10]. Of these, 38 157 men aged <60 years and with serum PSA levels of <4 ng/mL and normal serum creatinine levels were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

Association between serum prostate‐specific antigen level, liver function tests and lipid profile in healthy men

et al. 2008

Self Cite

View full text Add to dashboard Cite

who were aged < 60 years and had serum PSA levels of < 4 ng/mL and serum creatinine levels of < 1.4 mg/dL were enrolled between January 2002 and December 2006. Body weight and height were measured, and levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP, TB, FBS, TC, TG, and HDL, and serum PSA were measured. RESULTSThe mean ( SD ) age of the study population was 44.4 (7.90) years and the mean PSA level 0.89 (0.51) ng/mL. In a univariate analysis there were significant interrelations between serum PSA level and age, BMI, AST, ALT, ALP, TB, HDL and FBS ( P < 0.05). The multiple logistic regression analyses using four percentiles (10th, 25th, 75th, 90th percentile) of serum PSA level showed trends that being older was associated with serum PSA level, and that BMI, ALT, HDL and FBS were negatively correlated with serum PSA level. CONCLUSIONSThese results suggest that serum PSA level was significantly influenced by age, BMI, ALT, HDL and FBS. Further studies are needed to confirm our results and to explain the underlying mechanisms. KEYWORDSprostatic neoplasms, prostate-specific antigen, liver function tests, high-density lipid, cholesterol Study Type -Aetiology (individual cohort study) Level of Evidence 2b

show abstract

Association of Obesity With Prostate Specific Antigen and Prostate Specific Antigen Velocity in Healthy Young Men

Abstract: The results of this study show that age and weight changes are associated with substantial differences in prostate specific antigen velocity. Therefore, clinical interpretation of prostate specific antigen velocity may be biased by these factors.

Cited by 12 publications

References 19 publications

Prostate‐specific antigen concentration in young men: new estimates and review of the literature

Prostate‐specific antigen concentration in young men: new estimates and review of the literature

Prostate Cancer: Recent Trends in Korea

Association between serum prostate‐specific antigen level, liver function tests and lipid profile in healthy men

Contact Info

Product

Resources

About