Association of obesity withHelicobacter pyloriinfection: A retrospective study

Abstract

AIMTo explore the association between Helicobacter pylori (H. pylori) infection and obesity/weight gain in a Chinese population.METHODSOur primary outcome was the change in body mass index (BMI). The generalized linear models were used to explore the association between H. pylori infection and the change of BMI, and the logistic regression models were used to explore the association between H. pylori infection and obesity.RESULTSA total of 3039 subjects were recruited and analyzed, of which 12.8% were obese. The prevalence of H. pylori infection was 53.9% (1639/3039) overall and 54.6% (212/388) in the obese subjects. The change of BMI in the H. pylori (+) group was not significantly higher than that in the H. pylori (-) group after adjustment for potential confounding factors [RR = 0.988, 95%CI: 0.924-1.057, P = 0.729]. The prevalence of obesity decreased 1.1% in the H. pylori (+) group and 0.5% in the H. pylori (-) group. The RR of H. pylori infection for obesity was 0.831 (95%CI: 0.577-1.197, P = 0.321) after the adjustment.CONCLUSIONH. pylori infection was not associated with overweight/obesity observed from the retrospective study in this Chinese population.

Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

“…However, other BMI groups showed no difference compared with the normal BMI group. And the association between obesity and H. pylori infection is controversial, and the causality of these associations has not been proven 2, 21, 22. We also investigated the correlation between BMI and residence style after high school (city vs noncity) but observed no significant correlation between the two (data not shown).…”

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

“…Among 13 autoimmune diseases evidence in support of a probable role of HPI was found in four—TP, Graves’ disease, neuromyelitis optica and psoriasis [ 361 ]. Just to mention some examples of contradictory conclusions: many reports and meta-analyses suggested a positive correlation between HPI, metabolic associated fatty liver disease (MAFLD; previous term non-alcoholic fatty liver disease, NAFLD) [ 362 , 363 , 364 , 365 , 366 , 367 , 368 , 369 , 370 , 371 , 372 ], type 2 diabetes mellitus (DM)/insulin resistance [ 373 , 374 , 375 , 376 , 377 ], diabetic complications [ 378 , 379 , 380 ] and obesity [ 381 , 382 ], whereas others did not found such associations [ 383 , 384 , 385 , 386 , 387 , 388 , 389 ] and some described an inverse correlation of HPI with obesity [ 390 , 391 , 392 ]. Similarly, there is discrepancy between various studies regarding links between HPI and cardiovascular diseases (CVD) [ 333 , 393 , 394 , 395 , 396 , 397 , 398 , 399 , 400 ].…”

“…HPI has been reported to increase the risk of adult-onset asthma [ 443 ] and systemic lupus erythematosus [ 444 ]. A significantly higher HPI incidence rate was found in patients with Sjogren syndrome [ 445 ], autoimmune thyroid disease [ 446 , 447 , 448 ], multiple sclerosis [ 447 , 448 ] and no association between HPI and body mass index/obesity was observed in different populations [ 388 , 449 , 450 ]. The huge heterogeneity of asthma and other mentioned above diseases may, at least partially, contribute to the controversies in the publications.…”

Central obesity is associated with helicobacter pylori infection: a large-scale cross-sectional retrospective study in West China

“…But the relationship between H. pylori infection and obesity remains controversial [2][3][4][5][6][7]. Some studies identified a positive correlation [3,[8][9][10], while others found a negative correlation [4,7] or even no correlation [2,11]. A meta-analysis of 18 observational studies involving over 10,000 subjects found a higher body mass index (BMI) among H. pylori-positive subjects compared with H. pylori-negative subjects [12].…”