Association of obesity with hypertension and dyslipidemia in type 2 diabetes mellitus subjects

Anari, Razieh; Amani, Reza; Latifi, Seyed Mahmoud; Veissi, Masoud; Shahbazian, Hajieh

doi:10.1016/j.dsx.2016.07.004

Cited by 38 publications

(32 citation statements)

References 34 publications

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“… 17 , 18 This also holds true for further risk factors such as dyslipidemia and hypertension and their triangle association. 18 – 20 Moreover, the metabolic-syndrome-associated risks are reduced in the elderly with a lower impact on mortality. 21 Finally, smoking triggers insulin resistance and is also well known as one of the main risk factors for diabetes.…”

Section: Discussionmentioning

confidence: 99%

Type 2 diabetes in older patients: an analysis of the DPV and DIVE databases

Mark

Sziegoleit²,

Putz

et al. 2020

Therapeutic Advances in Endocrinology

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Background: The clinical profile differs between old and young patients with type 2 diabetes mellitus (T2DM). We explored, based on a large real-world database, patient and disease characteristics and actual treatment patterns by age. Methods: The analysis was based on the DIVE and DPV registries of patients with T2DM. Patients were analyzed by age groups 50–59 (middle-young), 60–69 (young-old), 70–79 (middle-old), 80–89 (old), and 90 years or more (oldest-old). Results: A total of 396,719 patients were analyzed, of which 17.7% were 50–59 years, 27.7% 60–69 years, 34.3% 70–79 years, 18.3% 80–89 years and 2.0% at least 90 years. We found that (a) T2DM in old and oldest-old patients was characterized much less by the presence of metabolic risk factors such as hypertension, obesity, dyslipidemia and smoking than in younger patients; (b) the HbA1c was much lower in oldest-old than in middle-young patients (7.2 ± 1.6% versus 8.0 ± 2.2%; p < 0.001), but it was associated with higher proportions of patients with severe hypoglycemia (7.0 versus 1.6%; p < 0.001); (c) this was potentially associated with the higher and increasing rates of insulin use in older patients (from 17.6% to 37.6%, p < 0.001) and the particular comorbidity profile of these patients, for example, chronic kidney disease (CKD); (d) patients with late diabetes onset had lower HbA1c values, lower bodyweight and less cardiovascular risk factors; (e) patients with a longer diabetes duration had a considerable increase in macrovascular and even more microvascular complications. Conclusion: In very old patients there is a need for frequent careful routine assessment and a tailored pharmacotherapy in which patient safety is much more important than blood-glucose-lowering efficacy.

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Section: Discussionmentioning

confidence: 99%

Type 2 diabetes in older patients: an analysis of the DPV and DIVE databases

Mark

Sziegoleit²,

Putz

et al. 2020

Therapeutic Advances in Endocrinology

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show abstract

“…These results were in agreement with the previous studies. [31–34] The rise of obesity in the Arabian Gulf is due to several factors, including significant growths in incomes resulting from the rich deposits of oil reserves and the resultant impact of rapid urbanization and improved living conditions. [35] The Arab countries in the Middle East as High-income countries such as Arab Gulf countries or Intermediate-income countries such as Egypt, Jordan, Iraq and Lebanon have been a drastic change in food consumption patterns in these countries as dietary habits and excessive consumption of fatty, salty and processed food and lack of exercise due to change in life style are important factors.…”

Section: Discussionmentioning

confidence: 99%

Association between salivary amylase enzyme activity and obesity in Saudi Arabia

2019

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Obesity is a significant public health concern that predisposes individuals to a high risk of premature mortality. Previous studies also reported that low serum concentrations of AMY1 have been associated with obesity. The aimed of the study to assess the relationship between salivary amylase (AMY1) activity and body mass index (BMI) in Saudi male and female adults in Riyadh. This study included a total of 200 (100 individuals who were overweight and obese and 100 who had normal body weight [control individuals]) Saudi participants aged 20 to 50 years old. They were recruited from physical fitness clubs and were school employees in Riyadh City. The dietary food intake was assessed using a 24-hour dietary recall. The activity of the AMY1 was measured using a microplate fluorescence reader. A significant ( P ≤ .05) increase was observed in the incidence of hypertension, dyslipidemia, diabetes mellitus (DM), and family history of overweight and obesity in overweight and obese individuals than in the control individuals, and these were in parallel to the significant increase in weight, waist circumference (WC), hip circumference (HC), systolic blood pressure (SBP), diastolic blood pressure (DBP), and BMI. A significant ( P ≤ .05) increase was also observed in the carbohydrate and total fat dietary intake of overweight and obese individuals in relation to the respective dietary reference intake (DRI) values. AMY1 activity was significantly lower than the reference values in the overweight and obese group. Furthermore, AMY1 activity was significantly ( P ≤ .05) reverse with weight, WC, HC, and BMI in both males and females in the overweight and obese group. In conclusion, the Saudi overweight and obese population seems to be at risk of low AMY1, which correlates with their obesity.

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“…Obesity is a heterogeneous disorder that is related to environmental and genetic factors. This phenotype is associated with the emergence of type 2 diabetes, hypertension, and cardiovascular disease [ 17 ]. As a proinflammatory state, obesity correlates also with the secretion of key regulators of adipocyte differentiation and energy balance such as adipokines and matrix metalloproteinases (MMPs) [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population

et al. 2017

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Aims The impact of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 -181A/G, and MMP-12 -82A/G variants and plasma MMP levels on obesity and microvascular reactivity in Tunisians. Methods Our population included 202 nonobese and 168 obese subjects. Anthropometric, biochemical, and microvascular parameters were determined according to standard protocols. PCR-RFLP and ELISA were used to determine the genetic variants and levels of MMPs, respectively. Results The MMP-3 45Glu (G) allele associates with higher anthropometric values and MMP-3 levels compared to AA genotype carriers (BMI (kg/m2): 30 ± 0.51 versus 27.33 ± 0.8, P = 0.004; MMP-3 levels: 7.45 (4.77–11.91) versus 5.21 (3.60–10.21) ng/ml, P = 0.006). The MMP-12 -82G allele was also associated with higher BMI values when compared to subjects carrying the AA genotype (31.41 ± 0.85 versus 28.76 ± 0.43, P < 0.001). Individuals carrying the MMP-3 45G or MMP-12 -82G variants were also associated with a higher risk for severe forms of obesity (MMP-3: OR = 1.9, P = 0.002; MMP-12: OR = 2.63, P = 0.003). Similarly, the MMP-7 -181G allele was associated with a higher MMP-7 level and an increased risk for morbid obesity when compared to AA genotype carriers (0.32 (0.31–0.60) versus 0.18 (0.17–0.24) ng/ml, P = 0.01; OR = 1.67, P = 0.02, resp.). Conclusion MMP-3, MMP-7, and MMP-12 polymorphisms associate with obesity risk and its severity.

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Association of obesity with hypertension and dyslipidemia in type 2 diabetes mellitus subjects

Cited by 38 publications

References 34 publications

Type 2 diabetes in older patients: an analysis of the DPV and DIVE databases

Type 2 diabetes in older patients: an analysis of the DPV and DIVE databases

Association between salivary amylase enzyme activity and obesity in Saudi Arabia

Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population

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